Results 191 to 200 of about 312,346 (337)

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Induction of neutralizing antibody responses by AAV5-based vaccine for respiratory syncytial virus in mice [PDF]

Guangxu Ma, Zeping Xu, Chinyu Li, Feng Zhou, Branda Hu, Junwei Guo, Changwen Ke, Liqing Chen, Guilin Zhang, Hungyan Lau, Hudan Pan, Xixin Chen, Runze Li, Liang Liu   +13 more
openalex   +1 more source

Gallium‐Doped MXene Nanozymes Protect Liver Through Multi‐Death Pathway Blockade and Hepatocyte Regeneration

Advanced Science, EarlyView.
This study develops gallium‐doped V2C MXene nanozymes (Ga‐V2C) to treat acetaminophen‐induced liver injury through multi‐death pathway blockade and hepatocyte regeneration. Unlike conventional single‐target therapies like N‐acetylcysteine, Ga‐V2C nanozymes enable oxidative stress suppression, apoptosis, and ferroptosis inhibition, and enhanced ...
Xiaopeng Cai, Jingwen Deng, Liqing Wang, Junjie Su, Dongyi Xian, Yilang Yan, Xinyu Yang, Chuanbin Wu, Tingting Peng, Yuan Ding, Guilan Quan, Weilin Wang, Min Zhou, Chao Lu   +13 more
wiley   +1 more source

Development of broadly neutralizing antibodies against Omicron variants from existing neutralizing antibodies in clinical trials. [PDF]

Virol J
Huang Y, Lin Z, Guo X, Zhang F, Wang Y, Zhang Z, Chen J, Liu L, Zhu M, Li Y, Ni M, Zhen Z, Wu Z, Ling X, Zhou S, Xi Y, Yu Y, Liang W, Zhao J, Li L, He J, Sang L.   +21 more
europepmc   +1 more source

A GLUTAMATE CYSTEINE LIGASE Gene StGSH1 Regulated by StERF10 Enhanced Glutathione Accumulation and Adaptation to Low Phosphorus Stress in Potato

Advanced Science, EarlyView.
The StERF10‐StGSH1 module coordinates glutathione (GSH) biosynthesis under low‐phosphorus stress. The low‐phosphate‐induced AP2/ERF transcription factor StERF10 directly activates the transcription of StGSH1 and enhances GSH accumulation. Consequently, GSH scavenges reactive oxygen species and provides sulfur for sulfolipid synthesis, facilitating the ...
Xiaocheng Tian, Mingjun Li, Xiaojia Huang, Markus Wirtz, Xiaohui Zheng, Shilong Fan, Jiang Tian, Shaoqun Liu, Zhonghua Liu, Hongbo Zhao   +9 more
wiley   +1 more source

Sand fly-associated phlebovirus with evidence of neutralizing antibodies in humans and dogs in Kosovo. [PDF]

Emerg Microbes Infect
Kurum E, Jakupi X, Xhekaj B, Platzgummer K, Hoxha I, Walochnik J, Dvorák V, Hajdari D, Abazi P, Obwaller AG, Stefanovska J, Cvetkovikj A, Sherifi K, Charrel R, Kniha E, Ayhan N.   +15 more
europepmc   +1 more source

Antibody neutralization assay with SARS-CoV-2 and SARS-CoV pseudovirus v1

, 2020
Bei Wang, Wen-Hsin Sandy Lee, Cheng‐I Wang   +2 more
openalex   +1 more source

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection [PDF]

, 2015
Kevin O. Saunders, Amarendra Pegu, Ivelin S. Georgiev, Ming Zeng, Michael Joyce, Zhi-Yong Yang, Sung‐Youl Ko, Xuejun Chen, Stephen D. Schmidt, Ashley T. Haase, John-Paul Todd, Saran Bao, Peter D. Kwong, Srinivas S. Rao, John R. Mascola, Gary J. Nabel   +15 more
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Neutralizing Antibodies Against the Porcine Endogenous Retroviruses (PERVs). [PDF]

Viruses
Ban J, Krabben L, Kaufer BB, Denner J.
europepmc   +1 more source