Results 1 to 10 of about 195,460 (295)
Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer [PDF]
Cell Reports, 2022 Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers.Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty +13 moredoaj +2 more sourcesCooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]
Cell Reports, 2017 Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing Katie A. Howell, Jennifer M. Brannan, Christopher Bryan, Andrew McNeal, Edgar Davidson, Hannah L. Turner, Hong Vu, Sergey Shulenin, Shihua He, Ana Kuehne, Andrew S. Herbert, Xiangguo Qiu, Benjamin J. Doranz, Frederick W. Holtsberg, Andrew B. Ward, John M. Dye, M. Javad Aman +16 moredoaj +3 more sourcesEngineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways
iScience, 2022 Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine +22 moredoaj +1 more sourceMolecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus
Nature Communications, 2022 SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood.Fangzhu Zhao, Zachary T. Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D. Allen, Shawn Barman, Wen-Hsin Lee, Srirupa Chakraborty, Sandrasegaram Gnanakaran, Leigh M. Sewall, Gabriel Ozorowski, Oliver Limbo, Ge Song, Peter Yong, Sean Callaghan, Jessica Coppola, Kim L. Weisgrau, Jeffrey D. Lifson, Rebecca Nedellec, Thomas B. Voigt, Fernanda Laurino, Johan Louw, Brandon C. Rosen, Michael Ricciardi, Max Crispin, Ronald C. Desrosiers, Eva G. Rakasz, David I. Watkins, Raiees Andrabi, Andrew B. Ward, Dennis R. Burton, Devin Sok +31 moredoaj +1 more sourceThe diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2
Cell Reports, 2023 Summary: Animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.Joel D. Allen, Dylan P. Ivory, Sophie Ge Song, Wan-ting He, Tazio Capozzola, Peter Yong, Dennis R. Burton, Raiees Andrabi, Max Crispin +8 moredoaj +1 more sourceCleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design
Cell Reports, 2015 Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt +8 moredoaj +1 more sourceEfficient isolation of rare B cells using next-generation antigen barcoding
Frontiers in Cellular and Infection Microbiology, 2023 The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development.Jonathan Hurtado, Jonathan Hurtado, Jonathan Hurtado, Claudia Flynn, Claudia Flynn, Claudia Flynn, Jeong Hyun Lee, Jeong Hyun Lee, Jeong Hyun Lee, Eugenia C. Salcedo, Eugenia C. Salcedo, Eugenia C. Salcedo, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, David Nemazee, William R. Schief, William R. Schief, William R. Schief, William R. Schief, William R. Schief, Elise Landais, Elise Landais, Elise Landais, Devin Sok, Devin Sok, Devin Sok, Bryan Briney, Bryan Briney, Bryan Briney, Bryan Briney +36 moredoaj +1 more sourceHoles in the Glycan Shield of the Native HIV Envelope Are a Target of Trimer-Elicited Neutralizing Antibodies
Cell Reports, 2016 A major advance in the search for an HIV vaccine has been the development of a near-native Envelope trimer (BG505 SOSIP.664) that can induce robust autologous Tier 2 neutralization.Laura E. McCoy, Marit J. van Gils, Gabriel Ozorowski, Terrence Messmer, Bryan Briney, James E. Voss, Daniel W. Kulp, Matthew S. Macauley, Devin Sok, Matthias Pauthner, Sergey Menis, Christopher A. Cottrell, Jonathan L. Torres, Jessica Hsueh, William R. Schief, Ian A. Wilson, Andrew B. Ward, Rogier W. Sanders, Dennis R. Burton +18 moredoaj +1 more sourceGlutaraldehyde Cross-linking of HIV-1 Env Trimers Skews the Antibody Subclass Response in Mice
Frontiers in Immunology, 2017 Well-ordered soluble HIV-1 envelope glycoprotein (Env) spike mimetics such as Native Flexibly Linked (NFL) trimers display high homogeneity, desired antigenicity, and high in vitro stability compared to previous generation soluble HIV-1 Env trimers ...Martina Soldemo, Monika Àdori, Julian M. Stark, Yu Feng, Karen Tran, Richard Wilson, Lifei Yang, Javier Guenaga, Richard T. Wyatt, Gunilla B. Karlsson Hedestam +9 moredoaj +1 more sourceStructure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer
Nature Communications, 2018 Native-like soluble HIV envelope (Env) trimers are potential vaccine immunogens, and elimination of furin-dependence could provide a DNA-based alternative. Here, Sarkar et al.Anita Sarkar, Shridhar Bale, Anna-Janina Behrens, Sonu Kumar, Shailendra Kumar Sharma, Natalia de Val, Jesper Pallesen, Adriana Irimia, Devan C. Diwanji, Robyn L. Stanfield, Andrew B. Ward, Max Crispin, Richard T. Wyatt, Ian A. Wilson +13 moredoaj +1 more source
