Results 1 to 10 of about 300,221 (330)

Highly mutated antibodies capable of neutralizing N276 glycan-deficient HIV after a single immunization with an Env trimer [PDF]

Cell Reports, 2022
Summary: Elicitation of HIV broadly neutralizing antibodies (bnAbs) is challenging because unmutated bnAb precursors are rare and seldom bind HIV envelope glycoprotein (Env) trimers.
Jeong Hyun Lee, Catherine Nakao, Michael Appel, Amber Le, Elise Landais, Oleksandr Kalyuzhniy, Xiaozhen Hu, Alessia Liguori, Tina-Marie Mullen, Bettina Groschel, Robert K. Abbott, Devin Sok, William R. Schief, Shane Crotty   +13 more
doaj   +2 more sources

Engineering SARS-CoV-2 neutralizing antibodies for increased potency and reduced viral escape pathways

iScience, 2022
Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao, Celina Keating, Gabriel Ozorowski, Namir Shaabani, Irene M. Francino-Urdaniz, Shawn Barman, Oliver Limbo, Alison Burns, Panpan Zhou, Michael J. Ricciardi, Jordan Woehl, Quoc Tran, Hannah L. Turner, Linghang Peng, Deli Huang, David Nemazee, Raiees Andrabi, Devin Sok, John R. Teijaro, Timothy A. Whitehead, Andrew B. Ward, Dennis R. Burton, Joseph G. Jardine   +22 more
doaj   +2 more sources

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]

Cell Reports, 2017
Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing
Katie A. Howell, Jennifer M. Brannan, Christopher Bryan, Andrew McNeal, Edgar Davidson, Hannah L. Turner, Hong Vu, Sergey Shulenin, Shihua He, Ana Kuehne, Andrew S. Herbert, Xiangguo Qiu, Benjamin J. Doranz, Frederick W. Holtsberg, Andrew B. Ward, John M. Dye, M. Javad Aman   +16 more
doaj   +3 more sources

Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques [PDF]

Frontiers in Microbiology
A vaccine is considered essential for controlling the HIV pandemic and ultimately eradicating AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have shown the ability to protect against the simian counterpart of HIV, SIV, in rhesus macaques.
Jessica Coppola, Mara Parren, Raiza Bastidas, Karen Saye, Jacqueline Malvin, Joseph G. Jardine, Roxanne M. Gilbride, Sohita Ojha, Shana Feltham, David Morrow, Aaron Barber-Axthelm, Rachele Bochart, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Jeffrey D. Lifson, Louis J. Picker, Dennis R. Burton, Scott G. Hansen   +18 more
doaj   +2 more sources

Few and Far Between: How HIV May Be Evading Antibody Avidity [PDF]

, 2010
No ...
Bjorkman, Pamela J., Klein, Joshua S.
core   +32 more sources

Molecular insights into antibody-mediated protection against the prototypic simian immunodeficiency virus

Nature Communications, 2022
SIVmac239 infection of macaques is a favored model of human HIV infection, but antibody-mediated protection for SIVmac239 is insufficiently understood.
Fangzhu Zhao, Zachary T. Berndsen, Nuria Pedreño-Lopez, Alison Burns, Joel D. Allen, Shawn Barman, Wen-Hsin Lee, Srirupa Chakraborty, Sandrasegaram Gnanakaran, Leigh M. Sewall, Gabriel Ozorowski, Oliver Limbo, Ge Song, Peter Yong, Sean Callaghan, Jessica Coppola, Kim L. Weisgrau, Jeffrey D. Lifson, Rebecca Nedellec, Thomas B. Voigt, Fernanda Laurino, Johan Louw, Brandon C. Rosen, Michael Ricciardi, Max Crispin, Ronald C. Desrosiers, Eva G. Rakasz, David I. Watkins, Raiees Andrabi, Andrew B. Ward, Dennis R. Burton, Devin Sok   +31 more
doaj   +1 more source

The diversity of the glycan shield of sarbecoviruses related to SARS-CoV-2

Cell Reports, 2023
Summary: Animal reservoirs of sarbecoviruses represent a significant risk of emergent pandemics, as evidenced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
Joel D. Allen, Dylan P. Ivory, Sophie Ge Song, Wan-ting He, Tazio Capozzola, Peter Yong, Dennis R. Burton, Raiees Andrabi, Max Crispin   +8 more
doaj   +1 more source

Efficient isolation of rare B cells using next-generation antigen barcoding

Frontiers in Cellular and Infection Microbiology, 2023
The ability to efficiently isolate antigen-specific B cells in high throughput will greatly accelerate the discovery of therapeutic monoclonal antibodies (mAbs) and catalyze rational vaccine development.
Jonathan Hurtado, Jonathan Hurtado, Jonathan Hurtado, Claudia Flynn, Claudia Flynn, Claudia Flynn, Jeong Hyun Lee, Jeong Hyun Lee, Jeong Hyun Lee, Eugenia C. Salcedo, Eugenia C. Salcedo, Eugenia C. Salcedo, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Christopher A. Cottrell, Patrick D. Skog, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, Dennis R. Burton, David Nemazee, William R. Schief, William R. Schief, William R. Schief, William R. Schief, William R. Schief, Elise Landais, Elise Landais, Elise Landais, Devin Sok, Devin Sok, Devin Sok, Bryan Briney, Bryan Briney, Bryan Briney, Bryan Briney   +36 more
doaj   +1 more source

Kinetics of the neutralizing antibody response to respiratory syncytial virus infections in a birth cohort [PDF]

, 2013
The kinetics of respiratory syncytial virus (RSV) neutralizing antibodies following birth, primary and secondary infections are poorly defined. The aims of the study were to measure and compare neutralizing antibody responses at different time points in ...
Cane, Patricia, Medley, Graham, Mutunga, M. N., Nokes, D. James, Okiro, Emelda A., Sande, Charles J.   +5 more
core   +1 more source

Cleavage-Independent HIV-1 Env Trimers Engineered as Soluble Native Spike Mimetics for Vaccine Design

Cell Reports, 2015
Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycoprotein
Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt   +8 more
doaj   +1 more source