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Combining a rhesus cytomegalovirus/SIV vaccine with a neutralizing antibody to protect against SIV challenges in rhesus macaques [PDF]
Frontiers in MicrobiologyA vaccine is considered essential for controlling the HIV pandemic and ultimately eradicating AIDS. Neutralizing antibodies and MHC-E-restricted CD8+ T cells have shown the ability to protect against the simian counterpart of HIV, SIV, in rhesus macaques.
Jessica Coppola +18 more
doaj +2 more sources
Neutralizing Antibody Therapeutics for COVID-19 [PDF]
Viruses, 2021 The emergence of SARS-CoV-2 and subsequent COVID-19 pandemic has resulted in a significant global public health burden, leading to an urgent need for effective therapeutic strategies.
A. Hurt, A. Wheatley
semanticscholar +6 more sources
Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus [PDF]
Cell Reports, 2017 Summary: Drug combinations are synergistic when their combined efficacy exceeds the sum of the individual actions, but they rarely include ineffective drugs that become effective only in combination. We identified several “enabling pairs” of neutralizing
Katie A. Howell +16 more
doaj +3 more sources
A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition [PDF]
, 2013 The membrane proximal external region (MPER) of the HIV-1 glycoprotein gp41 is targeted by the broadly neutralizing antibodies 2F5 and 4E10. To date, no immunization regimen in animals or humans has produced HIV-1 neutralizing MPER-specific antibodies ...
Aasa-Chapman, Marlén M. I. +23 more
core +19 more sources
Early Treatment for Covid-19 with SARS-CoV-2 Neutralizing Antibody Sotrovimab.
New England Journal of Medicine, 2021 BACKGROUND Coronavirus disease 2019 (Covid-19) disproportionately results in hospitalization or death in older patients and those with underlying conditions. Sotrovimab is a pan-sarbecovirus monoclonal antibody that was designed to prevent progression of
Anil K Gupta +21 more
semanticscholar +1 more source
Nature Communications, 2021 Understanding how antibody responses to SARS-CoV-2 evolve during infection may provide important insight into therapeutic approaches and vaccination for COVID-19.
S. Dispinseri +19 more
semanticscholar +1 more source
iScience, 2022 Summary: The rapid spread of SARS-CoV-2 variants poses a constant threat of escape from monoclonal antibody and vaccine countermeasures. Mutations in the ACE2 receptor binding site on the surface S protein have been shown to disrupt antibody binding and ...
Fangzhu Zhao +22 more
doaj +1 more source
Neutralizing antibody titres in SARS-CoV-2 infections
Nature Communications, 2021 The SARS-CoV-2 pandemic poses the greatest global public health challenge in a century. Neutralizing antibody is a correlate of protection and data on kinetics of virus neutralizing antibody responses are needed.
E. Lau +12 more
semanticscholar +1 more source
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19
New England Journal of Medicine, 2020 Background Recent data suggest that complications and death from coronavirus disease 2019 (Covid-19) may be related to high viral loads. Methods In this ongoing, double-blind, phase 1–3 trial involving nonhospitalized patients with Covid-19, we ...
D. Weinreich +32 more
semanticscholar +1 more source
Science Translational Medicine, 2022 The waning efficacy of SARS-CoV-2 vaccines, combined with the continued emergence of variants resistant to vaccine-induced immunity, has reignited debate over the need for booster vaccine doses.
John P. Evans +7 more
semanticscholar +1 more source