Results 11 to 20 of about 2,621 (180)

Review of the anatomical basis for predicting plutonium alpha particle radiation induced osteogenic cancers. [PDF]

Anat Rec (Hoboken)
Abstract Plutonium was discovered and first synthesized in the early 1940's. Several isotopes of plutonium are used in nuclear technologies, 238Pu for heat generation and 239Pu for energy production and weapons. Both isotopes emit alpha particles, which pose a significant radiation hazard when incorporated into the body.
Miller SC.
europepmc   +2 more sources

Towards an adequate description of the dose-response relationship in BNCT of glioblastoma multiforme. [PDF]

Med Phys
Abstract Background Boron Neutron Capture Therapy (BNCT) is a binary radiotherapy based on the intravenous administration of a borated drug to the patient and the subsequent irradiation with a low‐energy neutron beam. The borated formulation accumulates in the tumor cells, and when neutrons interact with boron, a nuclear capture reaction occurs ...
Marcaccio B, Crepaldi M, Postuma I, Simeone E, Guidi C, Fatemi S, Ramos RL, Vercesi V, Ferrari C, Cansolino L, Delgrosso E, Liberto RD, Dondi D, Vadivel D, Chen YW, Chou FI, Peir JJ, Wu CJ, Tsai HY, Lee JC, Portu AM, Viegas AMD, González SJ, Bortolussi S.   +23 more
europepmc   +2 more sources

Evaluation of sodium borocaptate (BSH) and boronophenylalanine (BPA) as boron delivery agents for neutron capture therapy (NCT) of cancer: an update and a guide for the future clinical evaluation of new boron delivery agents for NCT. [PDF]

Cancer Commun (Lond)
Abstract Boron neutron capture therapy (BNCT) is a cancer treatment modality based on the nuclear capture and fission reactions that occur when boron‐10, a stable isotope, is irradiated with neutrons of the appropriate energy to produce boron‐11 in an unstable form, which undergoes instantaneous nuclear fission to produce high‐energy, tumoricidal alpha
Barth RF, Gupta N, Kawabata S.
europepmc   +2 more sources

Revolutionizing cancer treatment: The role of radiopharmaceuticals in modern cancer therapy. [PDF]

Precis Radiat Oncol
Steps involved in the preparation of radiopharmaceuticals Abstract Radiopharmaceutical therapy (RPT) is a precision medicine approach that involves the targeted delivery of radioactive atoms to tumor cells, representing a breakthrough strategy for cancer treatment.
Varghese TP, John A, Mathew J.
europepmc   +2 more sources

Advances in PET Imaging of α7 Nicotinic Receptors: From Radioligand Development to CNS Applications. [PDF]

Basic Clin Pharmacol Toxicol
ABSTRACT Positron emission tomography (PET) has significantly advanced our understanding of the brain by enabling non‐invasive imaging and quantification of molecular processes, including receptor binding. In this review, we explore the development and application of PET radioligands targeting the α7 nicotinic acetylcholine receptor (α7 nAChR), a ...
Magnussen JH.
europepmc   +2 more sources

¹⁷⁷Lu-Gold Nanohybrids in Radiotherapeutic Approaches Against Cancer. [PDF]

Small Sci
This article reviews the literature on nanoscale systems incorporating radioactive lutetium‐177 and gold nanoparticles as amplifying units, applied to internal radionuclide therapy against cancer. A presentation of the lutetium radionuclide, the radioenhancing effect of gold nanoparticles, tumor delivery strategies, and the state of the literature on ...
Ponchelle M, Pruszyński M, Gravel E, Doris E.   +3 more
europepmc   +2 more sources

A Laser Synthesis Route to Boron‐Doped Gold Nanoparticles Designed for X‐Ray Radiotherapy and Boron Neutron Capture Therapy Assisted by CT Imaging

Advanced Functional Materials, Volume 33, Issue 42, October 13, 2023., 2023
Au‐B nanoparticles are obtained by an efficient laser‐assisted synthetic procedure and are designed to act as radiosensitizers for combined X‐ray radiotherapy and boron neutron capture therapy guided by computed tomography imaging, thus allowing innovative combined radiotherapy approaches, with great potential benefits for simultaneous treatment of ...
Stefano Scaramuzza, Clara M.G. de Faria, Vito Coviello, Daniel Forrer, Luca Artiglia, Denis Badocco, Paolo Pastore, Paolo Ghigna, Ian Postuma, Laura Cansolino, Cinzia Ferrari, Silva Bortolussi, Riccardo Vago, Antonello E. Spinelli, Marina Bekić, Miodrag Čolić, Vincenzo Amendola   +16 more
wiley   +1 more source

3D bioprinted osteosarcoma model for experimental boron neutron capture therapy (BNCT) applications: Preliminary assessment

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 111, Issue 8, Page 1571-1580, August 2023., 2023
Abstract Osteosarcoma is the most frequently primary malignant bone tumor characterized by infiltrative growth responsible for relapses and metastases. Treatment options are limited, and a new therapeutic option is required. Boron neutron capture therapy (BNCT) is an experimental alternative radiotherapy able to kill infiltrative tumor cells spearing ...
Elena Delgrosso, Franca Scocozza, Laura Cansolino, Federica Riva, Michele Conti, Giada Loi, Ferdinando Auricchio, Ian Postuma, Silva Bortolussi, Lorenzo Cobianchi, Cinzia Ferrari   +10 more
wiley   +1 more source

Development of a stand‐alone precalculated Monte Carlo code to calculate the dose by alpha and beta emitters from the Ra‐224 decay chain

Medical Physics, Volume 50, Issue 8, Page 5176-5188, August 2023., 2023
Abstract Background Recent developments in alpha and beta emitting radionuclide therapy highlight the importance of developing efficient methods for patient‐specific dosimetry. Traditional tabulated methods such as Medical Internal Radiation Dose (MIRD) estimate the dose at the organ level while more recent numerical methods based on Monte Carlo (MC ...
Mojtaba Hoseini‐Ghahfarokhi, Yuji Kamio, Julien Mondor, Keyvan Jabbari, Jean‐François Carrier   +4 more
wiley   +1 more source

Analysis and experimental investigation of Apollo sample 12032,366‐18, a chemically evolved basalt from the Moon

Meteoritics &Planetary Science, Volume 57, Issue 4, Page 794-816, April 2022., 2022
Abstract Sample 12032,366‐18 is a 41.2 mg basaltic rock fragment collected during the Apollo 12 mission to the Moon. It is enriched in incompatible trace elements (e.g., 7 ppm Th), but does not have a bulk composition that would be considered a KREEP (enriched in potassium, rare earth elements, and phosphorous) basalt.
Amanda C. Stadermann, Bradley L. Jolliff, Michael J. Krawczynski, Christopher W. Hamilton, Jessica J. Barnes   +4 more
wiley   +1 more source