Results 121 to 130 of about 1,017,928 (387)

In Vitro Testing of Crude Natural Plant Extracts from Costa Rica for Their Ability to Boost Innate Immune Cells against Staphylococcus aureus

Biomedicines, 2017
The increasing occurrence of antibiotic-resistant Staphylococcus (S.) aureus tremendously limits the antibiotic-based treatment options; therefore, an open discussion of alternative treatment strategies is urgently needed.
Ragheda Yaseen, Katja Branitzki-Heinemann, Hani Moubasher, William N. Setzer, Hassan Y. Naim, Maren von Köckritz-Blickwede   +5 more
doaj   +1 more source

Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. [PDF]

, 2017
BACKGROUND: Central nervous system tuberculosis (CNS-TB) may be fatal even with treatment. Neutrophils are the key mediators of TB immunopathology, and raised CSF matrix metalloproteinase-9 (MMP-9) which correlates to neutrophil count in CNS-TB is ...
Brilha, S, Elkington, PT, Friedland, JS, Ong, CWM, Pabisiak, PJ, Roncaroli, F, Singh, P   +6 more
core   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Increased Neutrophil Secretion Induced by NLRP3 Mutation Links the Inflammasome to Azurophilic Granule Exocytosis

Frontiers in Cellular and Infection Microbiology, 2017
Heterozygous mutations in the NLRP3 gene in patients with cryopyrin associated periodic syndrome (CAPS) lead to hyper-responsive inflammasome function.
Jennifer L. Johnson, Mahalakshmi Ramadass, Ariela Haimovich, Matthew D. McGeough, Jinzhong Zhang, Hal M. Hoffman, Sergio D. Catz   +6 more
doaj   +1 more source

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
core   +2 more sources

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, EarlyView.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Neutrophil Effector Functions Are Not Impaired in Duffy Antigen Receptor for Chemokines (DARC)-Null Black South Africans

Frontiers in Immunology, 2019
Neutrophils are well-recognized for their pathogen killing mechanisms and disorders of neutrophil count and function are associated with recurrent infections.
Kewreshini K. Naidoo, Ayanda Ngubane, Pedzisai Gaza, Amber Moodley, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Thumbi Ndung'u, Christina F. Thobakgale, Christina F. Thobakgale   +9 more
doaj   +1 more source

Diverse stimuli engage different neutrophil extracellular trap pathways

eLife, 2017
Neutrophils release neutrophil extracellular traps (NETs) which ensnare pathogens and have pathogenic functions in diverse diseases. We examined the NETosis pathways induced by five stimuli; PMA, the calcium ionophore A23187, nigericin, Candida albicans ...
Elaine F Kenny, A. Herzig, R. Krüger, A. Muth, S. Mondal, P. Thompson, V. Brinkmann, H. Bernuth, A. Zychlinsky   +8 more
semanticscholar   +1 more source

Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. [PDF]

, 2018
Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE.
Doty, Daniel J, Fujinami, Robert S, Grist, Jonathan J, Lane, Thomas E, Marro, Brett S, Skinner, Dominic D, Syage, Amber R, Worne, Colleen   +7 more
core   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source