Results 221 to 230 of about 152,807 (272)

Targeting neutrophil elastase in cystic fibrosis

Expert Opinion on Therapeutic Targets, 2008
Cystic fibrosis (CF) is a lethal hereditary disease characterised by neutrophil-dominated lung inflammation. These abundant neutrophils produce neutrophil elastase (NE), a destructive serine protease that has direct actions on extracellular matrix proteins and has a role in the host response to inflammation and infection.This review examines the ...
Catherine M Greene
exaly   +3 more sources

Neutrophil elastase and cancer

Surgical Oncology, 2006
This mini-review summarizes our recent experimental and clinical studies on neutrophil elastase (NE) and cancer based on our original view point. Neoplasms metastasize as a result of a complex series of events. This process requires various degradative enzymes including proteases.
Takashi, Sato, Satoshi, Takahashi, Takao, Mizumoto, Michiko, Harao, Miwa, Akizuki, Miyuki, Takasugi, Takashi, Fukutomi, Jun-ichi, Yamashita   +7 more
openaire   +2 more sources

The Enzymatic and Release Characteristics of Sheep Neutrophil Elastase: A Comparison with Human Neutrophil Elastase

Biological Chemistry Hoppe-Seyler, 1992
Sheep are often used to study tissue damage following shock after traumatic injury and in the course of other diseases. The processes involved are thought to be caused at least in part by elastase released from polymorphonuclear leukocytes (PMNs). Since little is known about elastase and its role as a mediator of tissue damage in sheep, we studied the ...
W G, Junger, S, Hallström, F C, Liu, H, Redl, G, Schlag   +4 more
openaire   +2 more sources

Neutrophil elastase: Nonsense lost in translation

Cell Stem Cell, 2021
In this issue of Cell Stem Cell, Daniel Bauer and colleagues investigate the pathogenesis of ELANE-associated severe congenital neutropenia (SCN) and describe two potentially universal gene correction strategies for autosomal dominant disorders (Rao et al., 2021). One exploits nonsense-mediated decay to prevent translation of the mutant allele.
openaire   +2 more sources

Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment

2020
Tumor-associated neutrophils (TANs) play a major role during cancer development and progression in the tumor microenvironment. Neutrophil elastase (NE) is a serine protease normally expressed in neutrophil primary granules. Formation of neutrophil extracellular traps (NETs), a mechanism used by neutrophils, has been traditionally associated with the ...
Hai, Huang, Hongji, Zhang, Amblessed E, Onuma, Allan, Tsung   +3 more
openaire   +2 more sources

Activation of Human Prorenin by Neutrophil Elastase*

The Journal of Clinical Endocrinology & Metabolism, 1987
Although about 90% of human renin circulates as inactive prorenin, the mechanism of prorenin activation in vivo is not known. We found that human polymorphonuclear leukocytes (PMN) activate prorenin at a neutral pH. Prorenin was partially purified from human amniotic fluid, and its activation was measured by the release of angiotensin I from sheep ...
Y, Takada, H, Maruta, B, Wagner, X G, FA, H L, James, E G, Erdös   +5 more
openaire   +2 more sources

Neutrophil elastase unleashed

Blood, 2005
Comment on Massullo et al, page [3397][1] The frustration of animal models aside, a simple cell culture model offers insight into how mutant neutrophil elastase causes hereditary neutropenia.
openaire   +1 more source

Involvement of neutrophil elastase in crescentic glomerulonephritis

Human Pathology, 1997
To elucidate the role of neutrophils in the tissue damage of crescentic glomerulonephritis (GN), we examined neutrophils infiltrated in renal tissues and the localization of neutrophil elastase (NE), as a neutrophil-derived tissue destructive mediator, using an immunohistochemical technique with antibodies specific for neutrophils and neutrophil ...
T, Oda, O, Hotta, Y, Taguma, H, Kitamura, K, Sudo, I, Horigome, S, Chiba, N, Yoshizawa, H, Nagura   +8 more
openaire   +2 more sources

Neutrophil elastase and neutropenia

Blood, 2004
HEMATOPOIESIS Neutrophil elastase ([NE] also called elastase-2 [ELA-2]) is a powerful serine protease stored in the primary granule of neutrophils.[1][1] This enzyme is synthesized primarily at the promyelocyte stage of neutrophil development in the bone marrow.
openaire   +1 more source