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Plant Phenolics Inhibit Neutrophil Elastase
Planta Medica, 2006Human neutrophil elastase (HNE) is a serine protease, which is present in its active form in inflamed tissue as well as in psoriatic lesions. In extension of our research on natural compounds as inhibitors of HNE or of its release, several phenolics of different size were tested. The ellagitannins agrimoniin and pedunculagin were the most potent direct
Hrenn, Andrea +5 more
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Neutrophil Elastase as a Target in Lung Cancer
Anti-Cancer Agents in Medicinal Chemistry, 2012Human neutrophil elastase (HNE), a main actor in the development of chronic obstructive pulmonary diseases, has been recently involved in non-small cell lung cancer progression. It can act at several levels (i) intracellularly, cleaving for instance the adaptor molecule insulin receptor substrate-1 (IRS-1) (ii) at the cell surface, hydrolyzing ...
Moroy, Gautier +4 more
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Elastase, a marker for neutrophils in skin infiltrates
British Journal of Dermatology, 1986The enzyme elastase (EC 3.4.21.37) has proved to be a convenient and extremely sensitive marker for the quantification of neutrophils in cutaneous infiltrates. Fluorometric assay using the synthetic substrate MeOSuc-Ala-Ala-Pro-Val-N-methylcoumarin permitted the measurement of this enzyme in as few as five cells and was linear up to about 1000 cells ...
A M, Lammers +3 more
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Inhibition of Neutrophil Elastase by Mucus Glycoprotein
American Journal of Respiratory Cell and Molecular Biology, 1994Abstract A number of structurally diverse polyanions have been found to inhibit human leukocyte elastase (HLE) activity. The purpose of this study was to examine the effects of mucus glycoprotein (mucin), one of the most plentiful high molecular weight polyanions in the respiratory tracts, on HLE activity.
C, Nadziejko, I, Finkelstein
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Elastase expression by infiltrating neutrophils in gliomas
Neurological Research, 2000Polymorphonuclear neutrophil elastase is a neutral protease released by activated polymorphonuclear neutrophils and plays a crucial role in maintaining host defense. However, under certain conditions, this enzyme damages normal tissue and facilitates infiltration of tumor cells.
K, Iwatsuki +5 more
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The Role of Neutrophil Elastase in Chronic Inflammation
American Journal of Respiratory and Critical Care Medicine, 1994Abstract Passively released or actively secreted elastase from neutrophils has been linked to the pathologic processes of a variety of inflammatory diseases, including idiopathic pulmonary fibrosis, rheumatoid arthritis, adult respiratory distress syndrome, and cystic fibrosis.
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2011
The 2010 Biennial Meeting of the American Society for Matrix Biology (ASMB), Charleston, S.C., 24-27 October 2010.
Shum, DKY, Chan, SCH, Ip, SCH
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The 2010 Biennial Meeting of the American Society for Matrix Biology (ASMB), Charleston, S.C., 24-27 October 2010.
Shum, DKY, Chan, SCH, Ip, SCH
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Neutrophil elastase inhibitors as treatment for COPD
Expert Opinion on Investigational Drugs, 2002Chronic obstructive pulmonary disease, characterised by a slowly progressive, irreversible airways limitation, is a major worldwide cause of chronic morbidity and mortality. The imbalance between human neutrophil elastase and endogenous antiproteases may cause excess human neutrophil elastase in pulmonary tissues, which may be considered a major ...
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Neutrophil elastase: From mechanisms to therapeutic potential
Journal of Pharmaceutical Analysis, 2023Tianlu Wang, Weilin Zeng
exaly