Results 61 to 70 of about 152,807 (272)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors

Bangladesh Journal of Pharmacology, 2014
In the present study, we aimed to dock 17 different ligands of curcumin analogues with that of human neutrophil elastase. Molecular descriptors analysis using Molinspiration online tool was carried out including investigation on human neutrophil elastase
Radhakrishnan Narayanaswamy, Lam Kok Wai, Faridah Abas, Intan Safinar Ismail   +3 more
doaj   +1 more source

Biomarkers of cell damage, neutrophil and macrophage activation associated with in-hospital mortality in geriatric COVID-19 patients

Immunity & Ageing, 2022
Background The risk for symptomatic COVID-19 requiring hospitalization is higher in the older population. The course of the disease in hospitalised older patients may show significant variation, from mild to severe illness, ultimately leading to death in
M. Cardelli, E. Pierpaoli, F. Marchegiani, F. Marcheselli, F. Piacenza, R. Giacconi, R. Recchioni, T. Casoli, P. Stripoli, M. Provinciali, G. Matacchione, A. Giuliani, D. Ramini, J. Sabbatinelli, M. Bonafè, M. Di Rosa, A. Cherubini, C. Di Pentima, F. Spannella, R. Antonicelli, A. R. Bonfigli, F. Olivieri, F. Lattanzio   +22 more
doaj   +1 more source

Leveraging Microphysiological Systems to Facilitate Neutrophil‐Based Cancer Immunotherapy

Advanced Science, EarlyView.
Microphysiological systems are emerging as powerful human‐relevant platforms for studying neutrophil biology in cancer. Current applications of spheroids, organoids, and organ‐on‐a‐chip models are reviewed, together with future opportunities in behaviorome profiling, multi‐omics integration, personalized medicine, immune crosstalk, and multi‐organ ...
Shuai Shao, Markus Isfeld Diehl, Caroline N. Jones   +2 more
wiley   +1 more source

Reduced neutrophil granular proteins and post-treatment modulation in tuberculous lymphadenitis.

PLoS ONE, 2021
BackgroundNeutrophils are important for host innate immune defense and mediate inflammatory responses. Pulmonary tuberculosis (PTB) is associated with increased neutrophil granular protein (NGP) levels in the circulation.
Gokul Raj Kathamuthu, Kadar Moideen, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu   +4 more
doaj   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

F. necrophorum Ecotin Inhibits Human Plasma Kallikrein and Human Neutrophil Elastase [PDF]

, 2015
Background: Fusobacterium necrophorum is a causative agent of Lemierre’s syndrome (LS) which is characterised by thrombophlebitis of the jugular vein and bacteraemia. F. necrophorum is a Gram-negative, anaerobic bacterium known to possess virulence genes
Greenwell, P., Kimmitt, P.T., Wright Katie Greenwell Pamela   +2 more
core  

Neutrophil elastase alters the murine gut mirobiota resulting in enhanced Salmonella colonization

, 2012
The intestinal microbiota has been found to play a central role in the colonization of Salmonella enterica serovar Typhimurium in the gastrointestinal tract.
Gill, Navkiran, Antunes, L. Caetano M., Hartmann, Martin, Al-Zahrani, Fatimah, Finlay, B. Brett, Sekirov, Inna, Willing, Benjamin P., Ferreira, Rosana B. R.   +7 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Splenic Tropism and Spleen‐Modulated Systemic Inflammation in Acute Plasmodium vivax Malaria

American Journal of Hematology, EarlyView.
ABSTRACT In chronic Plasmodium vivax (Pv) infection, the spleen accounts for over 98% of total‐body parasite biomass. Whether splenic tropism also occurs in acute infection and how the spleen influences pathogenesis have not been systematically explored. In Papua, Indonesia, we compared clinical and hematology data in 24 spleen‐intact and 25 previously
Steven Kho, Hasrini Rini, Noy N. Kambuaya, Syawal Satria, Freis Candrawati, Putu A. I. Shanti, King Alexander, Benediktus Andries, Aisah R. Amelia, Anjana Rai, Kim A. Piera, Agatha M. Puspitasari, Ristya Amalia, Pak Prayoga, Leo Leonardo, Maulina Hafidzah, Theo Situmorang, Dewi S. Margayani, Desandra A. Rahmayenti, Pengxing Cao, Enny Kenangalem, Leily Trianty, Damian Oyong, Julie A. Simpson, Rintis Noviyanti, Pierre A. Buffet, Jeanne R. Poespoprodjo, Nicholas M. Anstey   +27 more
wiley   +1 more source

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source