Results 71 to 80 of about 152,807 (272)
Acta Neuropathologica Communications, 2018 After spinal cord injury (SCI), neutrophil elastase (NE) released at injury site disrupts vascular endothelium integrity and stabilization. Angiopoietins (ANGPTs) are vascular growth factors that play an important role in vascular stabilization.
Hemant Kumar +13 more
doaj +1 more source
Role of neutrophil elastase in hypersecretion in asthma [PDF]
European Respiratory Journal, 1999 Goblet cell (GC) hyperplasia and mucous plugging are common in patients with acute asthma. These patients also show neutrophil recruitment into the airways. Neutrophils contain elastase, a potent secretagogue in airways. Therefore, it was reasoned that neutrophil recruitment, by releasing elastase, could result in GC hypersecretion.
J A, Nadel, K, Takeyama, C, Agustí
openaire +2 more sources
Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez +7 more
wiley +1 more source
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Neutrophil extracellular traps in patients with pulmonary tuberculosis
Respiratory Research, 2017 Tuberculosis is a devastating infectious disease causing many deaths worldwide. Recent investigations have implicated neutrophil extracellular traps (NETs) in the host response to tuberculosis. The aim of the current study was to obtain evidence for NETs
Anne Jan van der Meer +16 more
doaj +1 more source
Neutrophil Extracellular Traps Block Fibrinolysis in Ischemic Stroke
Annals of Neurology, EarlyView.Objectives Intravenous thrombolysis (IVT) failure in acute ischemic stroke (AIS) is frequent, but its causes remain elusive. We investigated whether biologically relevant intrathrombus concentrations of tissue plasminogen activator (tPA) were achieved in failed IVT and whether neutrophil extracellular traps (NETs) contributed to this therapeutic ...
Mialitiana Solo Nomenjanahary +21 more
wiley +1 more source
Characterisation of Neutropenia-Associated Neutrophil Elastase Mutations in a Murine Differentiation Model In Vitro and In Vivo. [PDF]
PLoS ONE, 2016 Severe congenital neutropenia (SCN) is characterised by a differentiation block in the bone marrow and low neutrophil numbers in the peripheral blood, which correlates with increased risk of bacterial infections. Several underlying gene defects have been
Michael Wiesmeier +3 more
doaj +1 more source
Colocalization analysis of neutrophil elastase and DNA by immunofluorescence.
, 2015 (A) lesion stained for neutrophil elastase (red), and (B) DNA (blue). (C) merge: elastase and DNA showing a neutrophil elastase positive cell with morphologically preserved nucleus. (D) NET containing neutrophil elastase, (E) and DNA. (F) merge: elastase
Erica C. F. Vasconcellos (772675) +10 more
core +1 more source
Autoprocessing of neutrophil elastase near its active site reduces the efficiency of natural and synthetic elastase inhibitors [PDF]
, 2015 An imbalance between neutrophil-derived proteases and extracellular inhibitors is widely regarded as an important pathogenic mechanism for lung injury. Despite intense efforts over the last three decades, attempts to develop small-molecule inhibitors for
Jenne, D. E. +9 more
core +1 more source
Respiratory Research, 2005 Background The separation of emphysema from fibrosis is not as clear-cut as it was thought in early studies. These two pathologies may be present at the same time in human lungs and in mice either instilled with elastolytic enzymes or bleomycin or ...
Martorana Piero A +6 more
doaj +1 more source