Results 61 to 70 of about 14,053 (187)

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source

Neutrophil gelatinase associated lipocalin-2 (Ngal) levels in preeclampsia

Clinical and Experimental Obstetrics & Gynecology, 2020
Objectives: Lipocalin-2 (LCN-2) is an immune modulator. It is highly associated with inflammation, ischemia, neoplastic invasion, and transformation. Preeclampsia (PE) is a pregnancy-related disease resulting from the incomplete invasion of trophoblasts.
H. Yolli, M.E. Demir, R. Yildizhan
doaj   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Gut microbiota dysbiosis and Long COVID susceptibility in chronic kidney disease

VIEW, EarlyView.
This study investigated gut microbiota dysbiosis and its association with Long COVID susceptibility in 224 hemodialysis patients. We found that 35.3% of patients developed Long COVID, characterized by neurological symptoms and elevated inflammatory markers, accompanied by significant gut microbiota alterations including enriched proinflammatory taxa ...
Meiling Jin, Lijie Ma, Yuqing Yuan, Kaiyi Zhu, Zhaohui Tong, Qianmei Sun   +5 more
wiley   +1 more source

Screening of early diagnostic markers of gentamicin-induced acute kidney injury in canines

Journal of Veterinary Research, 2019
The value of neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (Kim-1), and liver-type fatty acid binding protein (L-FABP) was assessed in early diagnosis of gentamicin-induced acute kidney injury (AKI) in dogs.
Zheng Jia-San, Jing-Nie, Zhu Ting-Ting, Ruan Hong-Ri, Xue-Wei, Rui-Wu   +5 more
doaj   +1 more source

Adipokines in Obese Asthma: A Complex Relationship Influenced More by Sex, Weight, and Oral Steroid Treatment Than Disease Severity

Allergy, EarlyView.
Adipokine secretion from adipose tissue may be involved in obesity‐related asthma, but it is unknown how adipokine levels relate to asthma characteristics. Plasma adipokines were measured in well‐characterized lean, overweight or obese patients with mild‐to‐moderate or severe asthma.
Lars I. Andersson, Maciej Kupczyk, Barbro Dahlén, Kenji Izuhara, Mina Gaga, Nikos M. Siafakas, Alberto Papi, Bianca Beghe, Guy Joos, Klaus F. Rabe, Elisabeth H. Bel, Sebastian L. Johnston, Pascal Chanez, Mark Gjomarkaj, Peter H. Howarth, Ewa Niżankowska‐Mogilnicka, Roelinde Middelveld, Sven‐Erik Dahlén, Apostolos Bossios, Anna James, on behalf of the BIOAIR (Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease) and ChAMP consortia   +20 more
wiley   +1 more source

Evaluating innovative metrics for the differential diagnosis of tubular injury in pediatric acute pyelonephritis: A cross-sectional observational study

Кубанский научный медицинский вестник
Background. The COVID-19 pandemic has revealed previously overlooked clinical features of infectious and inflammatory kidney diseases in pediatric patients.
N. I. Axmedjanova, G. N. Gapparova, D. J. Raximova   +2 more
doaj   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Neutrophil gelatinase-associated lipocalin reflects the severity of anemia without iron deficiency and secondary hyperparathyroidism in hemodialysis patients

İstanbul Kuzey Klinikleri, 2017
INTRODUCTION[|]Secondary hyperparathyroidism (SHPT) and anemia are the primary and most common complications in patients receiving hemodialysis (HD). Neutrophil gelatinase-associated lipocalin (NGAL) is a new marker to assess iron deficiency and manage ...
Irem Pembegul Yigit, Ramazan Ulu, Nevzat Gozel, Hulya Taskapan, Necip Ilhan, Ayhan Dogukan   +5 more
doaj   +1 more source

The miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell injury in diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
Suppression of miR‐145‐5p alleviates DN‐associated renal tissue damage by inhibiting NRF2/SLC7A11‐mediated ferroptosis of RTECs. ABSTRACT Purpose This study aimed to investigate the molecular mechanism by which the miR‐145‐5p/NRF2/SLC7A11 axis regulates ferroptosis‐mediated renal tubular epithelial cell (RTEC) injury in diabetic nephropathy (DN ...
Ganlin Wu, Yu Fang, Meirong Xu, Zuopeng Lu, Yu Cao, Yana Gao   +5 more
wiley   +1 more source