Results 91 to 100 of about 749,501 (334)

Blocking neutrophil integrin activation prevents ischemia-reperfusion injury. [PDF]

, 2015
Neutrophil recruitment, mediated by β2 integrins, combats pyogenic infections but also plays a key role in ischemia-reperfusion injury and other inflammatory disorders.
Ginsberg, Mark H, Liu, Zhenghui, McEver, Rodger P, Petrich, Brian G, Shao, Bojing, Yago, Tadayuki, Zhang, Nan   +6 more
core   +2 more sources

Neutrophils cultured ex vivo from CD34+ stem cells are immature and genetically tractable

Journal of Translational Medicine
Background Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to ...
Claire A. Naveh, Kiran Roberts, Przemysław Zakrzewski, Christopher M. Rice, Fernando M. Ponce-Garcia, Kathryn Fleming, Megan Thompson, Nawamin Panyapiean, Huan Jiang, Stephanie Diezmann, Pedro L. Moura, Ashley M. Toye, Borko Amulic   +12 more
doaj   +1 more source

Intratumoral CXCR4hi neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma

Frontiers in Immunology
Pediatric hepatoblastoma (HB) is the most common primary liver malignancy in infants and children. With great diversity and plasticity, tumor-infiltrating neutrophils were one of the most determining factors for poor prognosis in many malignant tumors ...
Zhengjing Lu, Zhengjing Lu, Xiaolin Wang, Xiaolin Wang, Jun Feng, Wenjia Chai, Wenjia Chai, Wei Wang, Wei Wang, Qixin Wang, Qixin Wang, Shen Yang, Wei Yang, Yan Su, Wenjun Mou, Wenjun Mou, Yun Peng, Yun Peng, Huanmin Wang, Jingang Gui, Jingang Gui   +20 more
doaj   +1 more source

Neutrophil and neutrophil extracellular trap involvement in neutrophilic asthma: A review

Medicine
Asthma is a highly prevalent chronic inflammatory disease characterized by variable airflow obstruction and airway hyperresponsiveness. Neutrophilic asthma (NA) is classified as “type 2 low” asthma, defined as 65% or more neutrophils in the total cell count.
Yuemu Li, Tianyi Yang, Baihua Jiang
openaire   +2 more sources

The Neutrophil [PDF]

, 2007
The neutrophil provides a crucial defence against fungal infections. This numerous phagocyte is recruited rapidly to sites of infection, where it detects pathogens through a range of pathogen-recognition receptors. Phagocytosis and the generation of a range of microbicidal molecules neutralises the pathogen, following which neutrophil death by ...
Dockrell, David H., McGrath, Emmet E., Whyte, Moria K.B., Sabroe, Ian   +3 more
openaire   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Skap2 is required for β2 integrin-mediated neutrophil recruitment and functions. [PDF]

, 2017
Integrin activation is required for neutrophil functions. Impaired integrin activation on neutrophils is the hallmark of leukocyte adhesion deficiency (LAD) syndrome in humans, characterized by impaired leukocyte recruitment and recurrent infections. The
Bardel, Bernadette, Block, Helena, Bokemeyer, Arne, Boras, Mark, Heitplatz, Barbara, Kliche, Stefanie, Lowell, Clifford, Reinhold, Annegret, Rossaint, Jan, Van Marck, Veerle, Volmering, Stephanie, Zarbock, Alexander   +11 more
core   +2 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]

, 2002
We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa, Han, Sang Kyou, Kim, Kwang Pyo, Kim, Young Jun, Leff, Alan R., Munoz, Nilda M., Sano, Hiroyuki, Zhu, Xiangdong   +7 more
core   +1 more source

CREB1-driven CXCR4hi neutrophils promote skin inflammation in mouse models and human patients

Nature Communications, 2023
Neutrophils have a pathogenic function in inflammation via releasing pro-inflammatory mediators or neutrophil extracellular traps (NETs). However, their heterogeneity and pro-inflammatory mechanisms remain unclear.
Jiaoling Chen, Yaxing Bai, Ke Xue, Zhiguo Li, Zhenlai Zhu, Qingyang Li, Chen Yu, Bing Li, Shengxian Shen, Pei Qiao, Caixia Li, Yixin Luo, Hongjiang Qiao, Erle Dang, Wen Yin, Johann E. Gudjonsson, Gang Wang, Shuai Shao   +17 more
doaj   +1 more source