Results 131 to 140 of about 26,994,982 (307)
A Framework for Patterns in Gaia: A case-study with Organisations
, 2004 The agent-oriented approach has been successfully applied to the solution of complex problems in dynamic open environments. However, to extend its use to mainstream computing and industrial environments, appropriate software tools are needed.
Luck, Michael +4 more
core +1 more source
Characterization of extracellular vesicles and miRNA released by cerebral organoids
Current Research in ToxicologyEnvironmental toxicants can contribute to the development of several neurodegenerative diseases. However, the mechanisms behind this pathology are still incompletely understood.
Brian B. Silver +3 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
A new teletraffic approach for network planning and evolution prediction
, 2011 This paper outlines a new multi-layer optimization approach that considers stochastic traffic composed of heavy tailed flows for optimizing traffic engineering and grooming, network design, dimensioning and planning, and evolution ...
Li, Fan +12 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Static or microfluidic? A comparative pilot study of an
NAM JournalBlood-brain barrier (BBB) permeation determines human brain exposure to chemicals and is therefore a prerequisite for neurotoxicity. However, the lack of toxicokinetic BBB models remains a critical uncertainty in regulatory in vitro risk assessment ...
Paul Kurtenbach +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Interweaving of New Digital Media and Active Methodologies
, 2019 Paper discusses the strategy of incorporating new digital media into active methodologies in ...
de Souza, Edegilson +1 more
core
New Approaches to Legal Methodology
, 2007 The topics of juridical everyday-business are relatively short lived and the commentary on this everyday-practice frequently runs behind. Following the rapid development of High-Court jurisdiction, especially at the EU-level, we notice a setting of methodological standards that cannot be comprehended by the guidelines of classical interpretation.
openaire +1 more source