Results 111 to 120 of about 26,994,982 (307)
New approach methodologies for risk assessment of urinary occurring toxicants
Ecotoxicology and Environmental SafetyThe reduction, refinement, and replacement of animal-based toxicological studies is becoming an essential requirement at academic, industrial, and governmental levels, turning new approach methodologies (NAMs) from alternatives into necessities.
Maximilian Jobst +6 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
Systems approach to agile methodologies of software development
, 2016 This bachelor thesis is focused to researching agile methodologies of software development using a systems approach. This thesis has two main objectives.
Urban, Daniel
core
Evaluating methodologies: a requirements engineering approach through the use of an exemplar [PDF]
, 2008 Systems development methodologies continue to be a central area of research in software engineering. As the nature of applications and systems usage move increasingly towards open networked environments, not only are new methodologies required, but new ...
Werneck, Vera +2 more
core
New synthetic methodologies under flow conditions as tool for API synthesis
, 2021 The preparation of medicinally relevant small molecules from biomass is a field of interest due to: 1) structural diversity obtained from biomass modification; 2) being potentially more sustainable and environmentally friendly approach, and; 3) more ...
Cavaca, Lídia A. S.
core
Frontiers in PharmacologyNew approach methodologies (NAMs) are advancing the reduction of animal testing by promoting human-relevant safety assessments across diverse applications, including cosmetics, pharmaceuticals, and environmental chemicals.
Vipul Gupta +5 more
doaj +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
New Interval Methodologies for Reliable Chemical Process Modeling
, 2002 The use of interval methods, in particular interval-Newton/generalized-bisection techniques, provides an approach that is mathematically and computationally guaranteed to reliably solve difficult nonlinear equation solving and global optimization ...
Chao-Yang Gau, Mark A. Stadtherr
core
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source