Results 101 to 110 of about 26,994,982 (307)

Editorial: Chemical testing using new approach methodologies (NAMs)

Frontiers in Toxicology, 2022
Andreas O. Stucki, Amy J. Clippinger, Tala R. Henry, Carole Hirn, Todd J. Stedeford, Claire Terry   +5 more
doaj   +1 more source

Towards Non-Animal Testing in European Regulatory Toxicology: An Introduction to the REACH Framework and Challenges in Implementing the 3Rs

European Journal of Risk Regulation
The European Union’s REACH (Registration, Evaluation, Authorisation and Restriction of Chemicals) Regulation aims to ensure high levels of human health and environmental protection, while also promoting alternatives to animal testing.
Katerina Stoykova
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Metamodel-Based Metrics for Agent-Oriented Methodologies

, 2012
A great number of methodologies has been already introduced in the agent-oriented software engineering field. Recently many of the authors of these methodologies also worked on their fragmentation thus obtaining portions (often called method or process ...
SEIDITA, Valeria, Cossentino, M, Migeon, F, Migeon, Frédéric, Bonjean, N, Cossentino, Massimo, CHELLA, Antonio, Gleizes, Marie-Pierre, Gleizes, MP, Bonjean, Noelie   +9 more
core  

In vitro metabolomics approaches to decipher the biochemical and cellular response to genotoxic compounds

EFSA Journal
New approach methodologies (NAMs) are gaining increasing attention within the scientific community as strategies to reduce the use of animal testing. Their integration into regulatory frameworks for chemical hazard and risk assessment in food and feed ...
Filipa Amaro, Ester Siniscalchi, Giorgia Maria Varalda, Eleonora Azzinnari, Joana Pinto, Paula Guedes dePinho, Egidio Iorio, Francesca Marcon   +7 more
doaj   +1 more source

Toxicity Assessment of Organophosphate Flame Retardants Using New Approach Methodologies

Toxics
Organophosphate flame retardants (OPFRs) have increasingly replaced polybrominated diphenyl ethers (PBDEs) in various consumer products and raw materials, due to regulatory restrictions on PBDEs.
Maryam Pyambri, Joaquim Jaumot, Carmen Bedia   +2 more
doaj   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Recovering Women's History: An Exploration into the Historical Record

, 2006
A poster announcing New Mexico Archives Week, October 15-21, 2006. The poster features a large photograph of Adelina "Nina" Otero-Warren from the Bergere Family Collection, State Records Center and Archives, Santa Fe, New Mexico.
New Mexico State Commission of Public Records - State Records Center and Archives
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source