Results 81 to 90 of about 26,994,982 (307)
New methodologic approaches for immunophenotyping acute leukemias.
Haematologica, 2001 Flow cytometry is nowadays the preferred method for immunophenotypic identification, enumeration and characterization of blast cells at diagnosis. Despite widespread application of standardized protocols, inter-laboratory reproducibility has still not been achieved.
BASSO, GIUSEPPE +3 more
openaire +3 more sources
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Some Findings Concerning Requirements in Agile Methodologies [PDF]
, 2009 gile methods have appeared as an attractive alternative to conventional methodologies. These methods try to reduce the time to market and, indirectly, the cost of the product through flexible development and deep customer involvement.
Rodriguez Gonzalez, Pilar +7 more
core +1 more source
ToxicsPer- and polyfluoroalkyl substances (PFAS) are of concern because of their potential thyroid hormone system disruption by binding to human transthyretin (hTTR). However, the amount of experimental data is scarce.
Marco Evangelista +2 more
doaj +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Advancing EFSA's regulatory science: Updated research and innovation needs
EFSA JournalThis editorial provides an update on research & innovation (R&I) needs that can support EFSA's regulatory science in the coming years. The paper presents research needs for EFSA's work in a number of domains: omics technologies; gut microbiome; new ...
European Food Safety Authority (EFSA) +10 more
doaj +1 more source
Lung microphysiological system for predicting antiviral drug efficacy for COVID-19
The MicrobeDevelopment of physiologically relevant in vitro models that recapitulate key aspects of SARS-CoV-2 infections has proven challenging due to limitations associated with current New Approach Methodologies (NAMS).
F. Mba Medie +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
New methodologies for optimal operation of water distribution systems for water quality purposes
, 1998 Two new methodologies have been developed for determining the optimal operation of water distribution systems for water quality purposes. These methodologies are based upon describing the operation as a discrete time optimal control problem that can be ...
Goldman, FE +2 more
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