Results 91 to 100 of about 26,994,982 (307)

The scientific imperative: why human-centered models must replace animal experimentation? [PDF]

Brazilian Journal of Biology
This paper aims to deconstruct the ethical and scientific impasse of using animals in biomedical research by proposing a paradigm shift towards human-centered methodologies.
Iván Vargas-Chaves
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Qualitative Methodologies: a practical guide [PDF]

, 2014
Fresh, insightful and clear, this exciting textbook provides an engaging introduction to the application of qualitative methodology in the real world.
Mills, Jane, Birks, Melanie
core  

Building Australia’s non-animal technologies ecosystem: a national cross-sector mapping and strategic insights from the non-animal technologies network (NAT-Net)

Frontiers in Toxicology
BackgroundNon-animal technologies (NATs; also termed new approach methodologies, NAMs) are rapidly reshaping biomedical research, safety testing and drug development by improving human relevance and reducing reliance on animal models.
Shafagh A. Waters, Shafagh A. Waters, Shafagh A. Waters, Adam P. Hill, Adam P. Hill, Adam P. Hill, Esther S. Pronker, Gerard E. Kaiko, Gerard E. Kaiko, Gungun Lin, Gungun Lin, Simon Keely, Simon Keely, Simon Keely, Laura Collie, Laura Collie, Laura Collie, Wojciech Chrzanowski, Wojciech Chrzanowski, Wojciech Chrzanowski, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero, Anai Gonzalez-Cordero   +22 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Evaluating Methodologies: A Requirements Engineering Approach Through the Use of an Exemplar [PDF]

, 2004
. Systems development methodologies continue to be a central area of research in software engineering. As the nature of applications and systems usage move increasingly towards open networked environments, not only are new methodologies required, but new
Vera Werneck, Luiz Marcio Cysneiros, Werneck, Vera, Yu, Eric, Eric Yu, Cysneiros, Luiz Marcio   +5 more
core  

Systematic and quantitative analyses of hollow fiber model of Mycobacterium abscessus lung disease studies and new dosing recommendations

Microbiology Spectrum
Guideline-based combination therapy achieves sputum culture conversion rates in 23%–34% of patients with Mycobacterium abscessus-complex lung disease. Thus, new therapies are needed.
Shashikant Srivastava, Tawanda Gumbo
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

New Methodologies for Measuring and Monitoring Nuclear Decay Parameters for Time Dependent Behavior

, 2018
In this work new methodologies for measuring and monitoring nuclear decay parameters is explored. A determination of the tritium half-life by measuring the current of a betavoltaic device is presented.
Kay, Matt J
core  

New Graphical Approach to Railway Infrastructure Capacity Analysis [PDF]

, 2015
A variety of methodologies are being used across Europe for the estimation of railway infrastructure capacity. This paper introduces the basic principles of the methodologies used – analytical methodology (e.g.
Abramović, Borna, Jozef Gašparík, Martin Halás, Borna Abramović, Gašparík, Jozef, Halás, Martin   +5 more
core   +1 more source