Results 61 to 70 of about 26,994,982 (307)

A Procedural Approach to Evaluating Software Development Methodologies: The Foundation [PDF]

open access: yes, 1986
A procedure for evaluating software development methodologies is developed. Beginning with the issue of what constitutes a methodology, development of the evaluation procedure relies on the establishment of linkages among objectives, principles, and ...
Nance, Richard E.   +2 more
core   +1 more source

Rethinking non-human primate models for emerging viral infections after COVID-19

open access: yesLaboratory Animal Research
Non-human primates (NHPs) retain particular value in emerging viral infection research when questions require integrated analysis of systemic viral kinetics, protective immunity, tissue pathology, or longitudinal outcomes.
Dong-Yeon Kim, Jung Joo Hong
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Sonic Methodologies of Sound

open access: yes, 2020
‘Sonic Methodologies of Sound’ in the Bloomsbury Handbook of Sonic Methodologies, Marcel Cobussen and Michael Bull eds, London and NY: Bloomsbury, 2020. The scope of this essay as it is indicated by the title might seem self-evident.
Voegelin, Salomé, Salomé Voegelin
core   +1 more source

Editorial [PDF]

open access: yes, 2012
Welcome to the first issue of Visual Methodologies, a new on-line visual studies journal which will critically engage with the development, utilisation and influence of visual experience in the production and consumption of knowledge of contemporary ...
Feighery, William
core   +1 more source

Design for Policy and Governance: New Technologies, New Methodologies

open access: yes, 2022
This position paper pays particular attention to new and upcoming areas of re-search where design disciplines and policy studies are exploring new ways to-ward convergence.
Mullagh, Louise   +7 more
core   +1 more source

From Reduction to Replacement: Challenges and Proposed Solutions for Animal-Free Safety Assessment of Hydrocarbon UVCB Substances

open access: yesNAM Journal
The European Commission (EC) developed a Roadmap to phase out animal testing, with milestones and practical steps across 15 different European chemical legislations (EC 2026).
Daniela Holland   +3 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

open access: yesFEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Software Engineering. Review of Methodologies [PDF]

open access: yes, 2016
W artykule dokonano przeglądu niektórych metodyk inżynierii oprogramowania oraz oceniono ich wady i zalety. Przedstawiono najnowsze tendencje szczególnie w obszarze rozwiązań typu BPMN.
Burgielski, Benedykt
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

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