Results 121 to 130 of about 26,994,982 (307)

Business process improvement methodologies: common factors and their respective efficacies [PDF]

Business process improvement (BPI) methodologies play an important role in increasing a business’s performance and its competitiveness. Since World War II, a number of these methodologies have been developed.
Nickerson, Winston
core  

Mesenchymal drift in ciliopathy iPSC-derived RPE reveals a convergent pathogenic cell state

Cell Reports
Summary: Ciliopathies comprise a spectrum of disorders involving mutations in over 150 genes affecting the primary cilium, with retinal degeneration as a prominent feature driven by concomitant developmental and maturation defects in photoreceptors and ...
Dominik Reichert, Sena Gul, Davide Ortolan, David McGaughey, Jair Montford, Jiwon Ryu, Alyssa S. Jeffrey, Colby F. Lewallen, Kati Veres, Rafael Villasmil, Noor D. White Carreiro, Stephen H. Tsang, Laryssa A. Huryn, Brian P. Brooks, Wadih Zein, Helen Louise May-Simera, Ruchi Sharma, Kapil Bharti   +17 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Discovering Methodologies for Integrated Product Design [PDF]

, 1998
The current methodologies for multi-disciplinary product design are based on compromising between different disciplines rather than integrating them. These methodologies do not use a systematic and holistic approach to the problem of multi-disciplinary ...
David C. Brown, Shakeri, Cirrus, Cirrus Shakeri, Brown, David C., Mohammad N. Noori, Noori, Mohammad N   +5 more
core  

Complement-ARIE: Catalyzing the development and adoption of new approach methodologies

NAM Journal
New approach methodologies (NAMs) are proving to be invaluable tools in basic and clinical research to better understand human health and disease, elucidate mechanisms, and study the efficacy and toxicity of novel therapeutics that can improve upon and ...
Kristifor Sunderic, Andrew M. Wright, Nicole Kleinstreuer, Victoria Ledbetter, Katelynn A. Milora, Christine Happel, Daniel Shaughnessy, Chariz P. Johnstone, Daniel Anthony Casco, Nikeya Macioce, Jacqui Marzec, Kristin Kano, Margaret J. Ochocinska, Danilo A. Tagle   +13 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Creating Responsive Information Systems with the Help of SSADM [PDF]

, 1993
In this paper, a program for a research is outlined. Firstly, the concept of responsive information systems is defined and then the notion of the capacity planning and software performance engineering is clarified.
Molnár, Bálint, Simon, Errol
core  

Overview and analysis of methodologies for building ontologies

, 2003
The use of methodologies in software and knowledge engineering is very extensive due to their important advantages. In the case of the development of ontologies, until now, several methodological proposals have been presented for building ontologies ...
Fernández-López, M., Gómez-Pérez, A.
core   +1 more source

New approach methodologies to address population variability and susceptibility

Human Genomics, 2023
Kimberly T. To, Nicole Kleinstreuer, Vasilis Vasiliou, Helena T. Hogberg   +3 more
doaj   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source