Results 51 to 60 of about 18,591,271 (238)

Wastewater analysis as a global toxicovigilance tool for the monitoring of new psychoactive substances [PDF]

, 2016
New psychoactive substances are a group of synthetic or naturally occurring drugs that mimic the effects of controlled illicit drugs. With limited information around potency, effects and health risks, there is international concern around their use and ...
Flores Quintana, Harold, Salgueiro González, Noelia, Cresswell, Sarah, Nadarajan, D, Laimou-Geraniou, M, Oh, Jeong-Eun, Burgard, Bijlsma, L, Gracia-Lor, E, Huchthausen, Julia, Bade, Richard, Quintana, HF, Nadarajan, Dhayaalini, Mueller, Jochen F., Kassinos, DF, Gracia Lor, Emma, Laimou Geraniou, M., Ceolotto, N, Bade, R., Sodre, FF, Oluseyi, Temilola, Thomaidis, Nikolaos, Van Wichelen, Natan, Burgard, DA, Boogaerts, Tim, Löve, Sue Ching, Wang, Degao, Castiglioni, Sara, Chappell, Andrew, et al., Yargeau, Viviane, Gerber, C, João Matias, Arndís, Ocenaskova, Vera, Bijlsma, Lubertus, Driver, EM, Halden, Rolf U., Fabriz Sodre, Fernando, Laimou-Geraniou, Maria, Psichoudaki, Magda, Baduel, C, Fatta Kassinos, Despo, Pineda Castro, Marco, Burgard, Daniel A., Sodre, Fernando Fabriz, Laimou Geraniou, Maria, Baduel, Christine, Kasprzyk-Hordern, Barbara, Phung, Kaitlyn, Halden, Rolf, Chappell, A, Gracia Marín, Elisa, Gerber, C., Subedi, Bikram, Sara Castiglioni, Daniel, Boogaerts, T, Driver, Erin M., Yin Lai, Foon, Sousa Nascimento, Fábio Marley, Castiglioni, S, Keller, E.L., Heath, Ester, Keller, Emma L., Silvino Gomes, Cezar, Ceolotto, Nicola, Kassinos, Despo Fatta, Nadarajan, D., Gerber, Cobus, Chappell, A., Baduel, C., Quintana, Harold Flores   +70 more
core   +1 more source

Generic bans of new psychoactive substances [PDF]

Zbornik Radova: Pravni Fakultet u Novom Sadu, 2018
New psychoactive substances attract attention of the researchers for more than ten years. Their appearance and increasing presence in the drug market require an adequate response from all responsible state authorities.
Risimović Radosav S.
doaj  

Prodrugs of New Psychoactive Substances (NPS): A New Challenge [PDF]

Journal of Forensic Sciences, 2020
AbstractThe concept of a substance acting as a prodrug for an intended drug is not new and has been known and utilized with particular benefits within medicine for efficacy and patient safety. Prodrugs of psychoactive substances are also not particularly new but this has also extended to considerations of prodrugs of new psychoactive substances (NPS ...
Elliott, S, Holdbrook, T, Brandt, SD
openaire   +2 more sources

A Whole City Response to the Use of Novel Psychoactive Substances (NPS) by Young People in Newcastle-upon-Tyne [PDF]

, 2015
In recent years, Novel Psychoactive Substances (NPS) (otherwise known as ‘legal highs’) have posed an increasingly significant problem for practitioners and policy makers due to their widespread availability, largely unknown chemical composition and ...
Irving, Adele, Parker, Chris, Soppitt, Sarah   +2 more
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Integration of Serum Neurofilament Light Chain and Cortical Dysfunction Improves Diagnostic Accuracy in ALS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether integration of serum neurofilament light chain (NfL) and cortical dysfunction improves diagnostic accuracy in amyotrophic lateral sclerosis (ALS) when applied alongside the Gold Coast criteria (GCC). Methods In this prospective study, 148 participants with suspected ALS were recruited (101 ALS and 47 with ALS ...
Aicee Dawn Calma, Nathan Pavey, Yukiko Tsuji, Amirul Ab Ghapar, Mehdi A.J. van den Bos, Bronwen Orden, Grace Lee, Linda Mekhael, Julie Ryder, Cláudia Santos Silva, David McDonald, Fakhria Kakar, Con Yiannikas, Matthew C. Kiernan, David A. Brown, Parvathi Menon, Steve Vucic   +16 more
wiley   +1 more source

Social representation of new psychoactive substances on Croatian news websites [PDF]

, 2021
U članku se medijska reprezentacija novih psihoaktivnih supstanci razmatra primjenom teorije društvene reprezentacije. Budući da nove psihoaktivne supstance u hrvatskom društvenom kontekstu predstavljaju relativno nepoznat fenomen, u članku je ...
Nikša Dubreta, Dubreta, Nikša, Lugarić, Karlo, Karlo Lugarić   +3 more
core   +1 more source

Brain‐Computer Interface Training Fosters Perceptual Skills to Detect Errors

Advanced Science, EarlyView.
Accurate perception of visuomotor errors underpins motor precision and learning, yet conventional behavioral training fails to improve sensitivity to subtle errors. Real‐time EEG‐based brain‐computer interface feedback targeting the error positivity component enhances perceptual learning of small errors.
Deland H. Liu, Fumiaki Iwane, Minsu Zhang, Leonardo G. Cohen, José del R. Millán   +4 more
wiley   +1 more source

Targeting the KCNC3‐Dependent Anterior Insular‐Lateral Orbitofrontal Cortex Glutamatergic Circuit Attenuates Post‐Traumatic Anxiety

Advanced Science, EarlyView.
Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li, Xiao‐Bo Qian, Hai‐Long Zhang, Di Li, Ling Ji, Xin‐Chun Xu, Jia‐Sheng Ding, Li‐Jun Yin, Li Zhang, Guang‐Yin Xu, Rong Gao   +10 more
wiley   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source