Results 91 to 100 of about 1,460,723 (393)

Molecular insights into Solanum sisymbriifolium’s resistance against Globodera pallida via RNA-seq

open access: yesBMC Plant Biology
Background The presence of potato cyst nematodes (PCN) causes a significant risk to potato crops globally, leading to reduced yields and economic losses. While the plant Solanum sisymbriifolium is known for its resistance to PCN and can be used as a trap
Raquel Varandas   +3 more
doaj   +1 more source

Poultry gut health – microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies

open access: yesJournal of Animal Science and Biotechnology, 2021
The gastrointestinal tract (GIT) health impacts animal productivity. The poultry microbiome has functions which range from protection against pathogens and nutrients production, to host immune system maturation.
Christiana Eleojo Aruwa   +3 more
doaj   +1 more source

Participating in Next Generation Sequencing [PDF]

open access: yesGenetic Testing and Molecular Biomarkers, 2015
On February 20, 2015, as part of the Precision Medicine Initiative, announced by President Obama, the Food and Drug Administration (FDA) held a meeting at the National Institutes of Health (NIH) all day. The meeting was titled “Optimizing FDA's Regulatory Oversight of Next Generation Sequencing Diagnostic Tests” (Food and Drug Administration, 2015 ...
openaire   +3 more sources

Erratum: Guidelines for diagnostic next-generation sequencing [PDF]

open access: yesEuropean Journal of Human Genetics, 2015
Abstract We present, on behalf of EuroGentest and the European Society of Human Genetics, guidelines for the evaluation and validation of next-generation sequencing (NGS) applications for the diagnosis of genetic disorders. The work was performed by a group of laboratory geneticists and bioinformaticians, and discussed with clinical ...
Matthijs, G.   +13 more
openaire   +8 more sources

Palindromic length sequence of the ruler sequence and of the period-doubling sequence [PDF]

open access: yesarXiv, 2020
In this article, we study the palindromic length sequences of the ruler sequence and of the period-doubling sequence. We give a precise formula of the palindromic length sequence of the first one and find a lower bound of the limit superior of the palindromic length sequence of the last one.
arxiv  

A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers

open access: yesBMC Genomics, 2012
BackgroundNext generation sequencing (NGS) technology has revolutionized genomic and genetic research. The pace of change in this area is rapid with three major new sequencing platforms having been released in 2011: Ion Torrent’s PGM, Pacific Biosciences’
M. Quail   +8 more
semanticscholar   +1 more source

Webcast courses in Medical Genetics and next generation sequencing [PDF]

open access: yes, 2013
The European School of Genetic Medicine organised the 26th Course in Medical Genetics and the 2nd Course in Next Generation Sequencing, between the 12th and 20th May 2013.
Borg, Isabella
core  

Next generation sequencing in cancer: opportunities and challenges for precision cancer medicine [PDF]

open access: yes, 2016
Over the past decade, testing the genes of patients and their specific cancer types has become standardized practice in medical oncology since somatic mutations, changes in gene expression and epigenetic modifications are all hallmarks of cancer ...
Fortina, Paolo   +2 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection.

open access: yesAnnual Review of Pathology, 2019
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004 ...
W. Gu, Steve Miller, C. Chiu
semanticscholar   +1 more source

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