Results 101 to 110 of about 1,444,385 (351)

Genetic landscape and clinical outcomes of autosomal recessive polycystic kidney disease in Kuwait

Heliyon
Background: Autosomal recessive polycystic kidney disease (ARPKD), a rare genetic disorder characterized by kidney cysts, shows complex clinical and genetic heterogeneity.
Mariam E. Alhaddad, Anwar Mohammad, Khadija M. Dashti, Sumi Elsa John, Yousif Bahbahani, Mohamed Abu-Farha, Jehad Abubaker, Thangavel Alphonse Thanaraj, Laila Bastaki, Fahd Al-Mulla, Mohammad Al-Ali, Hamad Ali   +11 more
doaj   +1 more source

Whole Genome In-Silico Analysis of South African G1P[8] Rotavirus Strains before and after Vaccine Introduction over a Period of 14 Years

Vaccines, 2020
Rotavirus G1P[8] strains account for more than half of the group A rotavirus (RVA) infections in children under five years of age, globally. A total of 103 stool samples previously characterized as G1P[8] and collected seven years before and seven years ...
Peter N. Mwangi, Milton T. Mogotsi, Mapaseka L. Seheri, M. Jeffrey Mphahlele, Ina Peenze, Mathew D. Esona, Benjamin Kumwenda, A. Duncan Steele, Carl D. Kirkwood, Valantine N. Ndze, Francis E. Dennis, Khuzwayo C. Jere, Martin M. Nyaga   +12 more
doaj   +1 more source

Length distribution of sequencing by synthesis: fixed flow cycle model

, 2014
Sequencing by synthesis is the underlying technology for many next-generation DNA sequencing platforms. We developed a new model, the fixed flow cycle model, to derive the distributions of sequence length for a given number of flow cycles under the ...
Kong, Yong
core   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Whole genome molecular analysis of respiratory syncytial virus pre and during the COVID-19 pandemic in Free State province, South Africa

Virus Research
Respiratory syncytial virus (RSV) is the most predominant viral pathogen worldwide in children with lower respiratory tract infections. The Coronavirus disease 2019 (COVID-19) pandemic and resulting nonpharmaceutical interventions perturbed the ...
Hlengiwe Sondlane, Ayodeji Ogunbayo, Celeste Donato, Milton Mogotsi, Mathew Esona, Ute Hallbauer, Phillip Bester, Dominique Goedhals, Martin Nyaga   +8 more
doaj   +1 more source

The application value of metagenomic next-generation sequencing in community-acquired purulent meningitis after antibiotics intervention [PDF]

, 2023
Lijuan Shangguan, Lanping XUE, Jing Shang, Hailong Wang   +3 more
openalex   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Corrigendum to “Whole genome molecular analysis of respiratory syncytial virus pre and during the COVID-19 pandemic in Free State province, South Africa” [Virus Research, Volume 347, September 2024, 199421]

Virus Research
Respiratory syncytial virus (RSV) is the most predominant viral pathogen worldwide in children with lower respiratory tract infections. The coronavirus disease 2019 (COVID-19) pandemic and resulting non-pharmaceutical interventions perturbed the ...
Hlengiwe Sondlane, Ayodeji Ogunbayo, Celeste Donato, Milton Mogotsi, Mathew Esona, Ute Hallbauer, Phillip Bester, Dominique Goedhals, Martin Nyaga   +8 more
doaj   +1 more source

Change-point model on nonhomogeneous Poisson processes with application in copy number profiling by next-generation DNA sequencing [PDF]

, 2012
We propose a flexible change-point model for inhomogeneous Poisson Processes, which arise naturally from next-generation DNA sequencing, and derive score and generalized likelihood statistics for shifts in intensity functions.
Shen, Jeremy J., Zhang, Nancy R.
core   +3 more sources

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source