Results 111 to 120 of about 519,004 (292)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Characterization of microRNA transcriptome in lung cancer by next‐generation deep sequencing

, 2014
Jie Ma, Kaiissar Mannoor, Lu Gao, Afang Tan, Maria Guarnera, Min Zhan, Amol C. Shetty, Sanford A. Stass, Lingxiao Xing, Feng Jiang   +9 more
openalex   +2 more sources

Next-generation-based targeted sequencing as an efficient tool for the study of the genetic background in Hirschsprung patients [PDF]

, 2015
Berta Luzón‐Toro, Laura Espino‐Paisán, Raquel Fernandez, Marta Martín-Sánchez, Guillermo Antiñolo, Salud Borrego   +5 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Chromosome-level phased genome assembly of the argan tree Sideroxylon spinosum

Scientific Data
Argan (Sideroxylon spinosum L., formerly Argania spinosa) is a tree endemic to Morocco, primarily valued for its seed oil. Growing interest in its biology and in genes linked to oil quality and stress resistance highlights the need for high-quality ...
Ivan D. Mateus, Abdellatif Essahibi, Pamela Nicholson, Mohamed Hijri, Ahmed Qaddoury, Laurent Falquet, Didier Reinhardt   +6 more
doaj   +1 more source

Case Report: Diagnosis of Human Alveolar Echinococcosis via Next-Generation Sequencing Analysis [PDF]

, 2021
Ke Li, Yubao Ma, Rui Ban, Qiang Shi
openalex   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

P660: NEXT-GENERATION SEQUENCING (NGS) FOR DETECTING BCR::ABL-INDEPENDENT MUTATIONS IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA WITH RESISTANCE TO TYROSINE KINASE INHIBITOR TREATMENT

, 2023
Daria Kustova, Anna Kirienko, Ekaterina Motyko, Vasily Shuvaev, Elizaveta Efremova, Elena Morozova, Sergey Sidorkevich, Irina Martynkevich   +7 more
openalex   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Single-cell RNA-sequencing highlights a curtailed NK cell function in convalescent COVID-19 pregnant women

Frontiers in Immunology
IntroductionDuring gestation the immune system undergoes dramatic remodelling to protect the maternal-fetal dyad from infections whilst also preventing fetal rejection.
Madhuri S. Salker, Nor Haslinda Abd Aziz, Natalia Carman Prodan, Zhiqi Yang, Aditya Kumar Lankapalli, Katrin Lazar, Mohamad Nasir Shafiee, Ersoy Kocak, Ersoy Kocak, Harivignesh Ganesan, Surya Sekhar Pal, Omer Khalid, Norhana Mohd Kasim, Aida Kalok, Norashikin Abdul Fuad, Alfred Lennart Bissinger, Tina Ganzenmueller, Thomas Iftner, Karl Oliver Kagan, Stephan Ossowski, Stephan Ossowski, Nicolas Casadei, Nicolas Casadei, Sara Y. Brucker, Olaf Riess, Olaf Riess, Yogesh Singh, Yogesh Singh, Yogesh Singh, Deutsche COVID-19 OMICS Initiative (DeCOI)   +29 more
doaj   +1 more source