Results 11 to 20 of about 1,460,723 (393)

Next-generation sequencing [PDF]

Breast Cancer Research, 2009
Next-generation sequencing (also known as massively parallel sequencing) technologies are revolutionising our ability to characterise cancers at the genomic, transcriptomic and epigenetic levels. Cataloguing all mutations, copy number aberrations and somatic rearrangements in an entire cancer genome at base pair resolution can now be performed in a ...
A Ashworth, A Meissner, A Piotrowski, A Visel, B Weigelt, B Weigelt, B Weigelt, C Alkan, C Greenman, C Marchio, C Sotiriou, CA Maher, CA Maher, CE Bruder, CG Mullighan, DA Wheeler, DS Tan, E Birney, E Iorns, E Pettersson, EM Swisher, ER Mardis, ES Lander, F Correa Geyer, FC Geyer, J Wang, JC Venter, Jorge S Reis-Filho, JR ten Bosch, JS Reis-Filho, KV Voelkerding, L Pusztai, LD Wood, M Sultan, MC Heinrich, MJ Fullwood, MJ Walter, MR Stratton, N Godin-Heymann, O Morozova, OA Hampton, PJ Campbell, Q Zhao, R Lister, SB Ng, SL Edwards, SP Shah, SP Shah, T Tucker, W Sakai, Z Wang   +50 more
openaire   +8 more sources

A normalization technique for next generation sequencing experiments [PDF]

, 2010
Next generation sequencing (NGS) are these days one of the key technologies in biology. NGS' cost effectiveness and capability of finding the smallest variations in the genome makes them increasingly popular.
Günter Klambauer, Karin Schwarzbauer, Andreas Mayr, Sepp Hochreiter   +3 more
openalex   +5 more sources

ResFinder – an open online resource for identification of antimicrobial resistance genes in next-generation sequencing data and prediction of phenotypes from genotypes

Microbial Genomics, 2022
Antimicrobial resistance (AMR) is one of the most important health threats globally. The ability to accurately identify resistant bacterial isolates and the individual antimicrobial resistance genes (ARGs) is essential for understanding the evolution and
A. F. Florensa, R. Kaas, P. Clausen, D. Aytan-Aktug, F. Aarestrup   +4 more
semanticscholar   +1 more source

Next-Generation Sequencing Technology: Current Trends and Advancements

Biology, 2023
Simple Summary Next-generation sequencing (NGS) is a powerful tool used in genomics research. NGS can sequence millions of DNA fragments at once, providing detailed information about the structure of genomes, genetic variations, gene activity, and ...
Heena Satam, Kandarp Joshi, Upasana Mangrolia, Sanober Waghoo, Gulnaz Zaidi, Shravani Rawool, Ritesh P Thakare, Shahid Banday, A. Mishra, Gautam Das, S. K. Malonia   +10 more
semanticscholar   +1 more source

In silico prediction of the enzymes involved in the degradation of the herbicide molinate by Gulosibacter molinativorax ON4T

Scientific Reports, 2022
Gulosibacter molinativorax ON4T is the only known organism to produce molinate hydrolase (MolA), which catalyses the breakdown of the thiocarbamate herbicide into azepane-1-carboxylic acid (ACA) and ethanethiol.
A. R. Lopes, E. Bunin, A. T. Viana, H. Froufe, A. Muñoz-Merida, D. Pinho, J. Figueiredo, C. Barroso, I. Vaz-Moreira, X. Bellanger, C. Egas, O. C. Nunes   +11 more
doaj   +1 more source

Transcriptomic studies reveal a key metabolic pathway contributing to a well-maintained photosynthetic system under drought stress in foxtail millet (Setaria italica L.) [PDF]

PeerJ, 2018
Drought stress is one of the most important abiotic factors limiting crop productivity. A better understanding of the effects of drought on millet (Setaria italica L.) production, a model crop for studying drought tolerance, and the underlying molecular ...
Weiping Shi, Jingye Cheng, Xiaojie Wen, Jixiang Wang, Guanyan Shi, Jiayan Yao, Liyuan Hou, Qian Sun, Peng Xiang, Xiangyang Yuan, Shuqi Dong, Pingyi Guo, Jie Guo   +12 more
doaj   +2 more sources

Methods to improve the accuracy of next-generation sequencing

Frontiers in Bioengineering and Biotechnology, 2023
Next-generation sequencing (NGS) is present in all fields of life science, which has greatly promoted the development of basic research while being gradually applied in clinical diagnosis.
Chu Cheng, Zhongjie Fei, Pengfeng Xiao
semanticscholar   +1 more source

Next-Generation Sequencing Technologies [PDF]

Cold Spring Harbor Perspectives in Medicine, 2018
Although DNA and RNA sequencing has a history spanning five decades, large-scale massively parallel sequencing, or next-generation sequencing (NGS), has only been commercially available for about 10 years. Nonetheless, the meteoric increase in sequencing throughput with NGS has dramatically changed our understanding of our genome and ourselves ...
McCombie, W Richard, McPherson, John D, Mardis, Elaine R   +2 more
openaire   +4 more sources

Genomic Analysis of G2P[4] Group A Rotaviruses in Zambia Reveals Positive Selection in Amino Acid Site 7 of Viral Protein 3

Viruses, 2023
The G2P[4] genotype is among the rotavirus strains that circulate commonly in humans. Several countries have reported its immediate upsurge after the introduction of rotavirus vaccination, raising concern about sub-optimal vaccine effectiveness against ...
Peter N. Mwangi, Robyn-Lee Potgieter, Julia Simwaka, Evans M. Mpabalwani, Jason M. Mwenda, Milton T. Mogotsi, Nonkululeko Magagula, Mathew D. Esona, A. Duncan Steele, Mapaseka L. Seheri, Martin M. Nyaga   +10 more
doaj   +1 more source

Fluorescent amplification for next generation sequencing (FA-NGS) library preparation. [PDF]

, 2020
BACKGROUND:Next generation sequencing (NGS) has become a universal practice in modern molecular biology. As the throughput of sequencing experiments increases, the preparation of conventional multiplexed libraries becomes more labor intensive ...
Chiniquy, Jennifer, Garber, Megan E, Hillson, Nathan J, Mukhopadhyay, Aindrila   +3 more
core   +1 more source