Results 31 to 40 of about 973,339 (276)
Target enrichment using parallel nanoliter quantitative PCR amplification [PDF]
, 2014 Background: Next generation targeted resequencing is replacing Sanger sequencing at high pace in routine genetic diagnosis. The need for well validated, high quality enrichment platforms to complement the bench-top next generation sequencing devices is ...
De Wilde, Bram +7 more
core +2 more sources
Viruses, 2023 Although the introduction of rotavirus vaccines has substantially contributed to the reduction in rotavirus morbidity and mortality, concerns persist about the re-emergence of variant strains that might alter vaccine effectiveness in the long term.
Robyn-Lee Potgieter +11 more
doaj +1 more source
Pharmacogenomics in children: advantages and challenges of next generation sequencing applications [PDF]
, 2013 Pharmacogenetics is considered as a prime example of how personalized medicine nowadays can be put into practice. However, genotyping to guide pharmacological treatment is relatively uncommon in the routine clinical practice. Several reasons can be found
De Paepe, Anne, Vanakker, Olivier
core +4 more sources
A new targeted CFTR mutation panel based on next-generation sequencing technology [PDF]
, 2017 Searching for mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) is a key step in the diagnosis of and neonatal and carrier screening for cystic fibrosis (CF), and it has implications for prognosis and personalized therapy ...
Alberti, Luisella +10 more
core +2 more sources
Defining Culture Conditions for the Hidden Nitrite-Oxidizing Bacterium Nitrolancea
Frontiers in Microbiology, 2020 Nitrification is a key process for N-removal in engineered and natural environments, but recent findings of novel nitrifying microorganisms with surprising features revealed that our knowledge of this functional guild is still incomplete.
Eva Spieck +8 more
doaj +1 more source
Journal of Neuroinflammation, 2022 Background Thiamine (vitamin B1) is a cofactor for enzymes of central energy metabolism and its deficiency (TD) impairs oxidative phosphorylation, increases oxidative stress, and activates inflammatory processes that can lead to neurodegeneration ...
Larissa M. G. Cassiano +4 more
doaj +1 more source
Pathogens, 2023 Africa has a high level of genetic diversity of rotavirus strains, which is suggested to be a possible reason contributing to the suboptimal effectiveness of rotavirus vaccines in this region.
Peter N. Mwangi +13 more
doaj +1 more source
Base calling for high-throughput short-read sequencing: dynamic programming solutions [PDF]
, 2013 Shreepriya Das and Haris Vikalo are with the Electrical and Computer Engineering Department, The University of Texas at Austin, Austin, Texas 78712, USABackground: Next-generation DNA sequencing platforms are capable of generating millions of reads in ...
Das, Shreepriya, Vikalo, Haris
core +3 more sources
Clustering and Alignment of Polymorphic Sequences for HLA-DRB1 Genotyping [PDF]
, 2013 Located on Chromosome 6p21, classical human leukocyte antigen genes are highly polymorphic. HLA alleles associate with a variety of phenotypes, such as narcolepsy, autoimmunity, as well as immunologic response to infectious disease.
A McKenna +35 more
core +3 more sources
Suppressing gain-of-function proteins via CRISPR/Cas9 system in SCA1 cells
Scientific Reports, 2022 SCAs are autosomal dominant neurodegenerative disorders caused by a gain-of-function protein with toxic activities, containing an expanded polyQ tract in the coding region.
Mariangela Pappadà +14 more
doaj +1 more source