Results 201 to 210 of about 1,444,385 (351)
Molecular Determinants of Response to Anti-Programmed Cell Death (PD)-1 and Anti-Programmed Death-Ligand 1 (PD-L1) Blockade in Patients With Non-Small-Cell Lung Cancer Profiled With Targeted Next-Generation Sequencing.
Journal of Clinical Oncology, 2018 H. Rizvi, F. Sánchez-Vega, Konnor C. La, Walid K. Chatila, P. Jonsson, D. Halpenny, A. Plodkowski, N. Long, J. Sauter, N. Rekhtman, T. Hollmann, K. Schalper, J. Gainor, R. Shen, A. Ni, K. Arbour, T. Merghoub, J. Wolchok, A. Snyder, J. Chaft, M. Kris, C. Rudin, N. Socci, M. Berger, B. Taylor, A. Zehir, D. Solit, M. Arcila, M. Ladanyi, Gregory Riely, N. Schultz, M. Hellmann +31 moresemanticscholar +1 more sourceAdaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch +16 morewiley +1 more sourceMacrogeographic genetic structure of Lutzomyia longipalpis complex populations using Next Generation Sequencing
, 2019 Aline Etelvina Casaril, Diego Peres Alonso, Karina Garcia Franco, Marcus Vinícius Niz Alvarez, Suellem Petilim Gomes Barrios, Wagner de Souza Fernandes, Jucelei de Oliveira Moura Infran, Ana Caroline Moura Rodrigues, Paulo Eduardo Martins Ribolla, Alessandra Gutierrez de Oliveira +9 moreopenalex +2 more sourcesPatient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert +16 morewiley +1 more sourceClinical application of next generation sequencing for Mendelian disease diagnosis in the Iranian population [PDF]
Ayda Abolhassani, Zohreh Fattahi, Maryam Beheshtian, Mahsa Fadaee, Raheleh Vazehan, Fatemeh Ahangari, Shima Dehdahsi, Mehrshid Faraji Zonooz, Elham Parsimehr, Zahra Kalhor, Fatemeh Peymani, Maryam Mozaffarpour Nouri, Mojgan Babanejad, Khadijeh Noudehi, Fatemeh Fatehi, Shima Zamanian Najafabadi, Fariba Afroozan, Hilda Yazdan, Bita Bozorgmehr, Azita Azarkeivan, Shokouh Sadat Mahdavi, Pooneh Nikuei, Farzad Fatehi, Payman Jamali, Mahmoud Reza Ashrafi, Parvaneh Karimzadeh, Haleh Habibi, Kimia Kahrizi, Shahriar Nafissi, Ariana Kariminejad, Hossein Najmabadi +30 moreopenalex +1 more sourceRapid pathogen detection by metagenomic next-generation sequencing of infected body fluids
Nature Network Boston, 2020 W. Gu, Xianding Deng, Marco B Lee, Yasemin Sucu, Shaun Arevalo, D. Stryke, S. Federman, Allan Gopez, Kevin R. Reyes, K. Zorn, H. Sample, Guixia Yu, Gurpreet Ishpuniani, B. Briggs, E. Chow, Amy Berger, M. Wilson, Candace Wang, Elaine D. Hsu, Steve Miller, J. Derisi, C. Chiu +21 moresemanticscholar +1 more source
