Results 231 to 240 of about 1,444,385 (351)

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Meta-Analysis of the Application Value of Metagenomic Next-Generation Sequencing Technology in the Diagnosis of Infectious Diseases of the Spine. [PDF]

JOR Spine
Cai X, Yi H, Chen K, Dai J, Yi J, Tu B, Wang Y, Li J, Zhuang J.   +8 more
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Next-Generation Sequencing for Cystic Fibrosis: Florida Newborn Screening Experience. [PDF]

Int J Neonatal Screen
Green DM, Polasky J, Weatherly M, Stalker H, Blanchard C, Kushner C, Couluris M, Ryland P, Sunitha I, Fong J, Crump S, Reeves E, Barnette K.   +12 more
europepmc   +1 more source

Utility and Challenges of Next Generation Sequencing in Pediatric Disorders [PDF]

, 2014
Mauro Longoni, Giuseppe Marangi, Marcella Zollino   +2 more
openalex   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Clinical characteristics of Torquetenovirus infected immunocompromised patients explored by metagenomic next-generation sequencing. [PDF]

Sci Rep
Zhang Q, Sun Y, Liu W, Zhao Q, Yuan K, Chen D.   +5 more
europepmc   +1 more source

Next-Generation Sequencing of Cerebrospinal Fluid for the Diagnosis of Neurocysticercosis

, 2018
Siyuan Fan, Xiaodong Qiao, Lei Liu, Honglong Wu, Jiali Zhou, Ruixue Sun, Qing Chen, Yan Huang, Chenhui Mao, Jing Yuan, Qiang Lü, Ying Ge, Yongjun Li, Haitao Ren, Jiawei Wang, Liying Cui, Weili Zhao, Hongzhi Guan   +17 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The significance of metagenomic next-generation sequencing and targeted next-generation sequencing in the diagnostic evaluation of patients with suspected pulmonary infections. [PDF]

Front Cell Infect Microbiol
Tang Y, Tang S, Zhang Y, Lin Z, Shan S.
europepmc   +1 more source