Results 261 to 270 of about 1,460,723 (393)

Identifying Copy Number Variations based on Next Generation Sequencing Data by a Mixture of Poisson Model [PDF]

, 2010
Karin Schwarzbauer, Karin Schwarzbauer, Günter Klambauer, Andreas Mayr, Sepp Hochreiter   +4 more
openalex   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Next Generation Sequencing for Clinical Diagnostics-Principles and Application to Targeted Resequencing for Hypertrophic Cardiomyopathy

, 2010
Karl V. Voelkerding, Shale Dames, Jacob Durtschi   +2 more
openalex   +1 more source

Application of metagenomic next-generation sequencing in pathogen detection of lung infections. [PDF]

Front Cell Infect Microbiol
Chen S, Ouyang T, Wang K, Hou X, Zhang R, Li M, Zhang H, He Q, Li X, Liu Z, Wang X, Huang B.   +11 more
europepmc   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Integrative analysis of next generation sequencing for small non-coding RNAs and transcriptional regulation in Myelodysplastic Syndromes [PDF]

, 2011
Dominik Beck, Steve Ayers, Jianguo Wen, Miriam Brandl, Tuan D. Pham, Paul Webb, Chung-Che Chang, Xiaobo Zhou   +7 more
openalex   +1 more source

The Next-Generation Sequencing Quality Initiative and Challenges in Clinical and Public Health Laboratories. [PDF]

Emerg Infect Dis
Cherney B, Diaz A, Chavis C, Ghattas C, Evans D, Arambula D, Stang H, Next-Generation Sequencing Quality Initiative.   +7 more
europepmc   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Reconstruction of Histone Modification Network from Next-generation Sequencing Data [PDF]

, 2011
Ngoc Tu Le, Tu Bao Ho
openalex   +1 more source

Identification of mutations in laboratory-evolved microbes from next-generation sequencing data using breseq.

Methods in molecular biology, 2014
Daniel E. Deatherage, Jeffrey E. Barrick
semanticscholar   +1 more source