Results 81 to 90 of about 1,444,385 (351)

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections

Communications Biology
Both bacterial and viral infections can trigger an overwhelming host response, leading to immunopathology and organ dysfunction. Multiple studies have reported dysregulated myeloid cell states in patients with bacterial sepsis or severe SARS-CoV-2 ...
Kimberly Kajihara, Donghong Yan, Gretchen L. Seim, Hannah Little-Hooy, Jing Kang, Cynthia Chen, Marco De Simone, Tim Delemarre, Spyros Darmanis, Haridha Shivram, Rebecca N. Bauer, Carrie M. Rosenberger, Sharookh B. Kapadia, Min Xu, Miguel Reyes   +14 more
doaj   +1 more source

Exploring the Diversity of Plant-Associated Viruses and Related Viruses in Riverine Freshwater Samples Collected in Berlin, Germany

Pathogens, 2023
Plant-infecting RNA viruses from 30 families and floating genera, as well as a great number of uncultured as yet-unclassified plant-associated viruses have been described. Even so, the plant RNA virosphere is still underexplored.
Roland Zell, Marco Groth, Lukas Selinka, Hans-Christoph Selinka   +3 more
doaj   +1 more source

Clinical Metagenomic Next-Generation Sequencing for Pathogen Detection.

Annual Review of Pathology, 2019
Nearly all infectious agents contain DNA or RNA genomes, making sequencing an attractive approach for pathogen detection. The cost of high-throughput or next-generation sequencing has been reduced by several orders of magnitude since its advent in 2004 ...
W. Gu, Steve Miller, C. Chiu
semanticscholar   +1 more source

Improving Pulmonary Infection Diagnosis with Metagenomic Next Generation Sequencing

Frontiers in Cellular and Infection Microbiology, 2021
Pulmonary infections are among the most common and important infectious diseases due to their high morbidity and mortality, especially in older and immunocompromised individuals.
Yiyi Qian, Hong-yu Wang, Yang Zhou, Hao-cheng Zhang, Yi-min Zhu, Xian Zhou, Yue Ying, P. Cui, Hong-long Wu, Wenhong Zhang, Jia-lin Jin, Jingwen Ai   +11 more
semanticscholar   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Putative mRNA Biomarkers for the Eradication of Infection in an Equine Experimental Model of Septic Arthritis

Veterinary Sciences
Septic arthritis (SA) in horses has long-term health implications. The success of its resolution hinges on the implementation of early, aggressive treatment, which is often sustained over a prolonged period. Common diagnostic methods do not allow for the
Roman V. Koziy, José L. Bracamonte, George S. Katselis, Daniel Udenze, Shahina Hayat, S. Austin Hammond, Elemir Simko   +6 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

Poultry gut health – microbiome functions, environmental impacts, microbiome engineering and advancements in characterization technologies

Journal of Animal Science and Biotechnology, 2021
The gastrointestinal tract (GIT) health impacts animal productivity. The poultry microbiome has functions which range from protection against pathogens and nutrients production, to host immune system maturation.
Christiana Eleojo Aruwa, Charlene Pillay, Martin M. Nyaga, Saheed Sabiu   +3 more
doaj   +1 more source

Next-generation sequencing in dermatology

Frontiers in Medicine, 2023
Over the past decade, Next-Generation Sequencing (NGS) has advanced our understanding, diagnosis, and management of several areas within dermatology.
Andrew D. King, Hany Deirawan, Paytra A. Klein, Bahar Dasgeb, Catherine I. Dumur, Darius R. Mehregan   +5 more
doaj   +1 more source