Results 1 to 10 of about 50 (25)
Next-Generation Sequencing [PDF]
, 2016 Endometrial cancers are the most frequently diagnosed gynecological malignancy and were expected to be the seventh leading cause of cancer death among American women in 2015. The majority of endometrial cancers are of serous or endometrioid histology. Most human tumors, including endometrial tumors, are driven by the acquisition of pathogenic mutations
Matthieu, Le Gallo +2 more
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Next-generation sequencing [PDF]
Breast Cancer Research, 2009 Next-generation sequencing (also known as massively parallel sequencing) technologies are revolutionising our ability to characterise cancers at the genomic, transcriptomic and epigenetic levels. Cataloguing all mutations, copy number aberrations and somatic rearrangements in an entire cancer genome at base pair resolution can now be performed in a ...
Atsushi, Toyoda, Asao, Fujiyama
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Next-Generation Sequencing [PDF]
Journal of Biomedicine and Biotechnology, 2010 It has been widely appreciated that the genome sequence is shaping the future biomedical research. The genome sequence provides a general framework for assembling fragmentary DNA information into landscape of biological structure and function [1]. The rapid advances in DNA sequencing technology are revolutionizing biomedical research.
Xiong, Momiao +3 more
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Next-generation sequencing demands next-generation phenotyping [PDF]
Human Mutation, 2012 Next-generation sequencing (NGS) is the most powerful diagnostic tool since the roentgenogram. NGS will facilitate diagnosis on a massive scale, allowing interrogation of all genes in a single assay. It has been suggested that NGS will decrease the need for phenotyping in general and medical geneticists in particular. We argue that NGS will shift focus
Hennekam, Raoul C. M. +1 more
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TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis, 2021 Next Generation Sequencing led to major knowledge gains in the molecular life sciences. But the new technology provides data that pose new challenges to both science and society. New fields of research are emerging and questions of identity on the basis of genetic analyses are being negotiated.
Elsbeth Bösl, Stefanie Samida
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Next-Generation Sequencing Technologies [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 Although DNA and RNA sequencing has a history spanning five decades, large-scale massively parallel sequencing, or next-generation sequencing (NGS), has only been commercially available for about 10 years. Nonetheless, the meteoric increase in sequencing throughput with NGS has dramatically changed our understanding of our genome and ourselves ...
McCombie, W Richard +2 more
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Next-Generation Sequencing Strategies [PDF]
Cold Spring Harbor Perspectives in Medicine, 2018 More than a decade ago, the term "next-generation" sequencing was coined to describe what was, at the time, revolutionary new methods to sequence RNA and DNA at a faster pace and cheaper cost than could be performed by standard bench-top protocols. Since then, the field of DNA sequencing has evolved at a rapid pace, with new breakthroughs allowing ...
Shawn E, Levy, Braden E, Boone
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Next Generation Sequencing [PDF]
Indian Journal of Medical and Paediatric Oncology, 2020 Guruprasad Bhat, Amit Kumar Jain
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DNA sequencing: generation next-next [PDF]
Nature Methods, 2008 Emboldened by the success of next-generation sequencing, scientists are pursuing the holy grail of genomics—the '$1,000 genome'—with single-molecule approaches. Nathan Blow reports.
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Next-generation Sequencing and Norovirus [PDF]
Future Virology, 2016 Cotten, Matthew, Koopmans, Marion
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