Results 251 to 260 of about 360,317 (299)

Retraction of "miR-654-5p promotes gastric cancer progression via the GPRIN1/NF-κB pathway". [PDF]

Open Med (Wars)
Zhou W, Li P, Jin P.
europepmc   +1 more source

Self‐Propelled In Situ Polymerized Nanoparticles Activating the STING Pathway for Enhanced Bladder Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐propelled nanomedicine delivery system forms DMCU nanoparticles in the bladder via in situ polymerization of dopamine hydrochloride, Mn2+, cGAMP, and urease. The urease‐driven propulsion enhances retention and drug delivery. These nanoparticles activate the STING pathway, stimulating dendritic cells and T cells to boost anti‐bladder cancer ...
Lei Peng, Anguo Zhao, Rongkang Li, Yujun Liu, Daitian Tang, Dashi Deng, Qi Zhuang, Rui Liang, Shaohua Zhang, Song Wu   +9 more
wiley   +1 more source

N4BP3 Activates TLR4-NF-κB Pathway in Inflammatory Bowel Disease by Promoting K48-Linked IκBα Ubiquitination. [PDF]

J Inflamm Res
Jiang W, Yin J, Han M, He W, Zhao Y, Hu J, Wang M, Wang S, Xu J, Deng C, Li J, Gong X, Shen Y.   +12 more
europepmc   +1 more source

Gas Bubbles from Biodegradable Magnesium Implants Convey Mechanical Cues and Promote Immune Cell Stimulation

Advanced Science, EarlyView.
Bubbles in soft tissue are the unavoidable consequence of magnesium implant degradation in patients, yet their biological significance remains unclear. Using advanced imaging and spatial transcriptomics, this study reveals a pronounced inflammatory and mechanical response near bubbles, contrasting with pro‐regenerative events closer to the implant ...
Heithem Ben Amara, Jincy Philip, Omar Omar, Peter Thomsen   +3 more
wiley   +1 more source

Fucosterol exerts an anti-atherosclerotic action via NF-κB and p38/Erk MAPK signaling pathways. [PDF]

Atheroscler Plus
Liu T, Zhang M, Wu X, Liu Z, Peng H, Gui F, Xiong W, Liu Q, Du G, Liu B, Zhang C, Ma J, Yuan Q, Li W, Chen Z.   +14 more
europepmc   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway. [PDF]

Mol Med
Li Y, Yang JY, Lin ML, Liu TZ, Lu WN, Yang Y, Liu ZC, Li JH, Zhang GQ, Guo JS.   +9 more
europepmc   +1 more source

Magnetite Micro/Nanorobots for Efficient Targeted Alleviation of Inflammatory Bowel Disease

Advanced Science, EarlyView.
Improved reactive oxygen species scavenging capacities of functionalized micro/nanorobots (MNRs) are useful for the treatment of inflammatory bowel disease (IBD). MNRs can break the harmful bacteria in IBD, thereby eliminating inflammation and restoring the intestinal barrier function.
Ying Feng, Yang Liu, Linlin Liu, Qian Yang, Miao An, Huaming Yang   +5 more
wiley   +1 more source

TAB2 Promotes Immune Escape and Chemoresistance Through NF-κB Pathway Activation in Cervical Cancer. [PDF]

J Cell Mol Med
Wu M, Zhang Y, Wang X, Zhou Y.
europepmc   +1 more source

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques

Advanced Science, EarlyView.
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu, Junjie Zhang, Yuxiang Zhao, Feixiang Fang, Siyu Zhang, Qiqi An, Jian Zhuang, Feng Xu, Fei Li   +8 more
wiley   +1 more source