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217 Altered Regulation of the Inhibitor IκBα Contributes to Changes in NF-κB Regulated Genes in the TILRR ko Mouse

Basic Science, 2015
Introduction Inflammatory responses are key drivers in the pathogenesis of atherosclerosis. We have identified a co-receptor, TILRR, a prominent activator of NF-IoB controlled responses, which we have demonstrated is highly expressed in atherosclerotic lesions.
Sarah Smith   +4 more
openaire   +1 more source

miR-675 promotes disease progression of non-small cell lung cancer via activating NF-κB signaling pathway

Cellular and Molecular Biology, 2017
Non-small cell lung cancer (NSCLC) is a major type of lung cancer significantly affected human life. Current studies have revealed potential role of miR-675 in the etiology of lung cancer. Therefore, in this study, we aimed to investigate the role of miR-675 in NSCLC cell line.
Y, Feng, C, Yang, D, Hu, X, Wang, X, Liu
openaire   +2 more sources

Lipopolysaccharide pretreatment inhibits oxidative stress-induced endothelial progenitor cell apoptosis via a TLR4-mediated PI3K/Akt/ NF-κB p65 signaling pathway

Cellular and Molecular Biology, 2019
Endothelial progenitor cells (EPCs) improve neovascularization and endothelium regeneration. Transplantation with EPCs is a therapeutic strategy for the treatment of ischemic diseases. However, the transplanted EPCs are susceptible to adverse environments such as hypoxia, inflammation and oxidative stress.
Meihui, Wang, Liang, Xia, Guosheng, Fu
openaire   +2 more sources

Effects of miR-7 on Hcy-induced rat cerebral arterial vascular smooth muscle cell proliferation, migration and inflammatory factor expression by targeting MMP-14 to regulate TLR4/NF-κB signaling pathway

Cellular and Molecular Biology, 2020
The current research aimed to investigate the effect of miR-7 targeting matrix metalloproteinase 14 (MMP-14) on homocysteine (Hcy)-induced rat cerebral artery vascular smooth muscle cells (VSMCs) proliferation, migration and inflammatory factor expression and its possible mechanism.
Hongdan, Ma   +3 more
openaire   +2 more sources

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