Results 81 to 90 of about 30,847 (205)

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study

Biomolecules, 2022
Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 (NRF2) protein is the master regulator of oxidative stress, which is at the basis of various chronic diseases including cancer.
Alessia Garufi, Giuseppa Pistritto, Valerio D’Orazi, Mara Cirone, Gabriella D’Orazi   +4 more
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Cytotoxic drugs activate KSHV lytic cycle in latently infected PEL cells by inducing a moderate ROS increase controlled by HSF1, NRF2 and p62/SQSTM1 [PDF]

, 2018
Previous studies have indicated that cytotoxic treatments may induce or not activate viral lytic cycle activation in cancer cells latently infected by Kaposi’s sarcoma-associated herpesvirus (KSHV). To investigate the molecular mechanisms responsible for
Angiolillo, Camilla, CIRONE, Mara, D’Orazi, Gabriella, FAGGIONI, Alberto, GILARDINI MONTANI, MARIA SAVERIA, GRANATO, Marisa   +5 more
core   +1 more source

17β-Estradiol strongly inhibits azoxymethane/dextran sulfate sodium-induced colorectal cancer development in Nrf2 knockout male mice [PDF]

, 2020
© 2020 The Author(s)Nuclear factor erythroid 2-related factor 2 (Nrf2) has dual effects on inflammation and cancer progression depending on the microenvironment. Estrogens have a protective effect on colorectal cancer (CRC) development.
Eun Yu, Jeong, Hee Nam, Ryoung, Hee Son, Joo, In Choi, Soo, Kim, Do-Hee, Kim, Nayoung, Lee, Ha-Na, Shin, Eun, Song, Chin-Hee, Surh, Young-Joon   +9 more
core   +1 more source

The Potential of Nrf2 Activation as a Therapeutic Target in Systemic Lupus Erythematosus

Metabolites, 2022
Inflammation and oxidative stress are well established in systemic lupus erythematosus (SLE) and are critical to the pathogenesis of autoimmune diseases.
Michelle T. Barati, Dawn J. Caster
doaj   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2) [PDF]

, 2017
Funding: Supported by grants MR/J001465/1 (JDH, MLJA, JFD and RJMcC) and MR/N009851/1 (JDH, MLJA, ATD-K and DJH) from the Medical Research Council of the UK and grants from Stony Brook Foundation and Reata Pharmaceuticals, Inc.
Axelsson, Begriche, Boulangé, Brunt, Burcelin, Camer, Cao, Chaudhari, Chen, Chowdhry, Dara, Deng, Dinkova-Kostova, Eletto, Fahey, Fang, Gluchowski, Haas, Hashimoto, Hayes, Herman, Honda, Hotamisligil, Hurtado del Pozo, Hwahng, Itoh, Jiang, Kay, Kobayashi, Lee, Lee, Lee, Lee, Li, Lugrin, Meakin, Michelotti, More, Okada, Okada, Oyadomari, Ramadori, Ron, Rutkowski, Saha, Saito, Schröder, Shimozono, Slocum, Sugimoto, Sun, Sunny, Takaki, Tilg, Ulven, Uruno, Vos, Wang, Wang, Wang, Wu, Wu, Xin, Xu, Yang, Zanotto-Filho, Zhang, Zheng   +67 more
core   +4 more sources

Transcription factor Nrf2 induces the up-regulation of lncRNA TUG1 to promote progression and adriamycin resistance in urothelial carcinoma of the bladder

Cancer Management and Research, 2019
Zhulei Sun,1 Gui Huang,1 Hepeng Cheng21Department of Pathology, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China; 2Department of Urology, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of ...
Sun Z, Huang G, Cheng H
doaj  

Nrf2 deficiency deteriorates diabetic kidney disease in Akita model mice

Redox Biology, 2022
Oxidative stress is an essential component in the progression of diabetic kidney disease (DKD), and the transcription factor NF-E2-related factor-2 (Nrf2) plays critical roles in protecting the body against oxidative stress.
Yexin Liu, Akira Uruno, Ritsumi Saito, Naomi Matsukawa, Eiji Hishinuma, Daisuke Saigusa, Hong Liu, Masayuki Yamamoto   +7 more
doaj   +1 more source