Results 141 to 150 of about 271,508 (291)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

[Regulation of NF-kappa B activity].

Postepy higieny i medycyny doswiadczalnej, 2003
Nuclear factor kappa B (NF-kappa B) is common proinflammatory transcription factor involved in expression of c.a. 300 different genes. It is usually present in the cytosol as an inactive complex and upon activation translocates into the nucleus. The mechanisms of activation of NF-kappa B are complex and they involve several different signaling pathways
Jakub, Siednienko, Wojciech A, Gorczyca
openaire   +1 more source

CFTR Regulates the Proliferation, Migration and Invasion of Cervical Cancer Cells by Inhibiting the NF-κB Signalling Pathway

Cancer Management and Research, 2020
Zhao Wu, 1 Jinke Li, 2 Yi Zhang, 2 Lina Hu, 3 Xue Peng 2 1Department of Obstetrics and Gynecology, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Chengdu, Sichuan, People’s Republic of China; 2Department ...
Wu Z, Li J, Zhang Y, Hu L, Peng X
doaj  

NF-kappa B expression in resected specimen of colonic cancer is higher compared to its expression in inflammatory bowel diseases and polyps. [PDF]

Sci Rep, 2022
Berkovich L, Gerber M, Katzav A, Kidron D, Avital S.   +4 more
europepmc   +1 more source

Nuclear factor-kappa B and diabetic nephropathy

Linchuang shenzangbing zazhi, 2019
Diabetes is a metabolic disease that affects most of the world’s population. Diabetic nephropathy(DN) is the main complication of diabetes mellitus and the main cause of end-stage renal diseases.
TAN Xiao-yan, YANG Ding-ping, DING Guohua   +2 more
doaj  

Galectin-3 promotes calcification of human aortic valve interstitial cells via the NF-kappa B signaling pathway. [PDF]

Cardiovasc Diagn Ther, 2022
Luo J, Wang S, Liu X, Zheng Q, Wang Z, Huang Y, Shi J.   +6 more
europepmc   +1 more source

Semi‐autonomous Navigation of Magnetic Microcarriers for Knee Cartilage Regeneration

Advanced Intelligent Systems, EarlyView.
Autonomous navigation of magnetic microcarriers in complex 3D environments is investigated through a semi‐autonomous strategy integrating magnetic actuation with monocular visual feedback. Real‐time global tracking is achieved via radio‐frequency‐based localization and depth estimation, while model‐based computation determines optimal steering forces ...
Kim Tien Nguyen, Cuong Manh Hoang, Jong‐Oh Park, Jayoung Kim   +3 more
wiley   +1 more source

NF-kappa-B activation unveils the presence of inflammatory hotspots in human gut xenografts. [PDF]

PLoS One, 2021
Nissim-Eliraz E, Nir E, Marsiano N, Yagel S, Shpigel NY.   +4 more
europepmc   +1 more source

2026 Update on the Management of Diffuse Large B‐Cell Lymphoma

American Journal of Hematology, EarlyView.
ABSTRACT Diffuse large B‐cell lymphoma (DLBCL) is the most common type of NHL in the Western Hemisphere. It comprises a heterogenous group of lymphomas, with different biology and clinical prognoses. R‐CHP remains the backbone of therapy, and frontline therapeutic options in fit patients are pola‐R‐CHP and R‐CHOP, whereas elderly or frail/unfit ...
Elise A. Chong, Emily B. Tomasulo, Stefan K. Barta   +2 more
wiley   +1 more source

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source