Results 11 to 20 of about 134,845 (295)

Constitutive NF-kappa B activity in neurons. [PDF]

Molecular and Cellular Biology, 1994
NF-kappa B is inducible transcription factor present in many cell types in a latent cytoplasmic form. So far, only immune cells including mature B cells, thymocytes, and adherent macrophages have been reported to contain constitutively active forms of NF-kappa B in the nucleus.
Kaltschmidt, Christian, Kaltschmidt, Barbara, Neumann, H., Wekerle, H., Baeuerle, P. A.   +4 more
openaire   +3 more sources

NO-Donor Nitrosyl Iron Complex with 2-Aminophenolyl Ligand Induces Apoptosis and Inhibits NF-κB Function in HeLa Cells

Scientia Pharmaceutica, 2018
NO donating iron nitrosyl complex with 2-aminothiophenyl ligand (2-AmPh complex) was studied for its ability to cause cell death and affect nuclear factor kappa B (NF-κB) signaling.
Tatiana Stupina, Anastasia Balakina, Tatiana Kondrat’eva, Galina Kozub, Natalia Sanina, Alexei Terent’ev   +5 more
doaj   +1 more source

Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling.

PLoS ONE, 2010
BackgroundI-kappa B kinase 2 (IKK2 or IKK-beta) is one of the most crucial signaling kinases for activation of NF-kappa B, a transcription factor that is important for inflammation, cell survival and differentiation.
Kalsoom Sughra, Andreas Birbach, Rainer de Martin, Johannes A Schmid   +3 more
doaj   +1 more source

Butyrolactone-I from Coral-Derived Fungus Aspergillus terreus Attenuates Neuro-Inflammatory Response via Suppression of NF-κB Pathway in BV-2 Cells

Marine Drugs, 2018
Butyrolactone-I (ZB5-1) from the coral-derived fungus Aspergillus terreus was investigated in this study to estimate its anti-neuroinflammatory effects on lipopolysaccharide (LPS)-induced BV-2 microglia cells.
Yuan Yuan Zhang, Yi Zhang, Yuan-Bei Yao, Xiao-Ling Lei, Zhong-Ji Qian   +4 more
doaj   +1 more source

TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway

Cells, 2018
Non-canonical NF-κB signalling plays important roles in the development and function of the immune system but it also is deregulated in a number of inflammatory diseases.
Laura D’Ignazio, Michael Batie, Sonia Rocha   +2 more
doaj   +1 more source

The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection

Biomedicines, 2018
Stressful conditions occuring during cancer, inflammation or infection activate adaptive responses that are controlled by the unfolded protein response (UPR) and the nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-κB ...
M. Lienhard Schmitz, M. Samer Shaban, B. Vincent Albert, Anke Gökçen, Michael Kracht   +4 more
doaj   +1 more source

Crosstalk between NF-κB and Nucleoli in the Regulation of Cellular Homeostasis

Cells, 2018
Nucleoli are emerging as key sensors of cellular stress and regulators of the downstream consequences on proliferation, metabolism, senescence, and apoptosis.
Jingyu Chen, Lesley A. Stark
doaj   +1 more source

The NF-kappa B inhibitor, celastrol, could enhance the anti-cancer effect of gambogic acid on oral squamous cell carcinoma

BMC Cancer, 2009
Background Gambogic acid (GA) is a major active ingredient of gamboge, a widely used traditional Chinese medicine that has been reported to be a potent cytotoxic agent against some malignant tumors.
Zhou Xiaojian, Zhang Ping, Yan Ming, Xu Qin, He Di, Zhang Zhiyuan, Duan Wenhu, Zhong Laiping, Ye Dongxia, Chen Wantao   +9 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

High Expression of Nuclear Transcription Factor-κB is Associated with Cisplatin Resistance and Prognosis for Ovarian Cancer

Cancer Management and Research, 2020
Yanyan Kan,1– 4 Juntian Liu,1– 4 Fangxuan Li1– 4 1Department of Cancer Prevention, Tianjin Medical University Cancer Institute and Hospital, Tianjin, People’s Republic of China; 2National Clinical Research Center for Cancer ...
Kan Y, Liu J, Li F
doaj