Results 171 to 180 of about 99,051 (206)
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NF-kappaB in renal inflammation.
Journal of the American Society of Nephrology : JASN, 2010The NF-kappaB family of transcription factors regulates the induction and resolution of inflammation. Two main pathways, classical and alternative, control the nuclear translocation of NF-kappaB. Classical NF-kappaB activation is usually a rapid and transient response to a wide range of stimuli whose main effector is RelA/p50. The alternative NF-kappaB
Ana Belen, Sanz +7 more
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Naturally occurring NF-kappaB inhibitors.
Mini reviews in medicinal chemistry, 2006NF-kappaB is a ubiquitous and well-characterised protein responsible for the regulation of complex phenomena, with a pivotal role in controlling cell signalling in the body under certain physiological and pathological conditions. Among other functions, NF-kappaB controls the expression of genes encoding the pro-inflammatory cytokines (e. g., IL-1, IL-2,
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Genes & development, 2004
The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood.
Matthew S, Hayden, Sankar, Ghosh
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The transcription factor NF-kappaB has been the focus of intense investigation for nearly two decades. Over this period, considerable progress has been made in determining the function and regulation of NF-kappaB, although there are nuances in this important signaling pathway that still remain to be understood.
Matthew S, Hayden, Sankar, Ghosh
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Vitamins and hormones, 2006
Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-kappaB (NF-kappaB). NF-kappaB is a ubiquitous transcription factor which is crucially involved in many biological
Dagmar, Kulms, Thomas, Schwarz
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Cytokines represent a heterogeneous group of soluble mediators which are involved in almost any physiological and pathological process. The release of many cytokines and numerous of their biological activities are mediated by nuclear factor-kappaB (NF-kappaB). NF-kappaB is a ubiquitous transcription factor which is crucially involved in many biological
Dagmar, Kulms, Thomas, Schwarz
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NF-kappaB in the nervous system.
Cold Spring Harbor perspectives in biology, 2009The transcription factor NF-kappaB has diverse functions in the nervous system, depending on the cellular context. NF-kappaB is constitutively activated in glutamatergic neurons. Knockout of p65 or inhibition of neuronal NF-kappaB by super-repressor IkappaB resulted in the loss of neuroprotection and defects in learning and memory.
Kaltschmidt, Barbara +1 more
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International journal of oncology, 2007
Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival. This review summarizes our understanding of the potentially important role of inflammation in cancer in general and pancreatic cancer in particular.
Zhiquan, Zhang, Basil, Rigas
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Pancreatic cancer is the most deadly of all gastrointestinal malignancies with near zero five-year survival. This review summarizes our understanding of the potentially important role of inflammation in cancer in general and pancreatic cancer in particular.
Zhiquan, Zhang, Basil, Rigas
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Noncanonical NF-kappaB Signaling Is Limited by Classical NF-kappaB Activity.
2014Precise regulation of nuclear factor kappaB (NF-kappaB) signaling is crucial for normal immune responses, and defective NF-kappaB activity underlies a range of immunodeficiencies. NF-kappaB is activated through two signaling cascades: the classical and noncanonical pathways.
Gray, Carolyn M. +6 more
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Regulation of NF-kappaB function.
Biochemical Society symposium, 2006In the 20 years since its discovery, research into the NF-kappaB (nuclear factor-kappaB) family of transcription factors has revealed an amazing diversity of functions. NF-kappaB proteins are regulators of the immune, inflammatory, stress, proliferative and apoptotic responses of a cell to a very large number of different stimuli.
Kirsteen J, Campbell, Neil D, Perkins
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Cold Spring Harbor perspectives in biology, 2010
David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.
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David Baltimore recalls the experiments that led to the discovery of the NF-kappaB transcription factor more than 20 years ago.
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Critical care medicine, 2000
Binding sites for the transcriptional regulatory factor nuclear factor kappa B (NF-kappaB) are present in the promoter regions of many of the proinflammatory cytokines and immunoregulatory mediators important in inducing acute inflammatory responses associated with critical illnesses.
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Binding sites for the transcriptional regulatory factor nuclear factor kappa B (NF-kappaB) are present in the promoter regions of many of the proinflammatory cytokines and immunoregulatory mediators important in inducing acute inflammatory responses associated with critical illnesses.
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