Results 201 to 210 of about 21,677 (225)
Solution Structure of the Core NFATC1/DNA Complex [PDF]
Cell, 1998 The nuclear factor of the activated T cell (NFAT) family of transcription factors regulates cytokine gene expression by binding to the promoter/enhancer regions of antigen-responsive genes, usually in cooperation with heterologous DNA-binding partners.
Pei Zhou, Volker Dotsch, Gerhard Wagner
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Critical role of NFATc1 in periapical lesions
International Endodontic Journal, 2010Zhang C, Yang L, Peng B. Critical role of NFATc1 in periapical lesions. International Endodontic Journal, 43, 109–114, 2010.AbstractAim To observe NFATc1 expression in experimental periapical lesions in rats.Methodology Apical periodontitis was induced in Wistar rats by occlusal pulp exposure in mandibular first molar teeth.
C, Zhang, L, Yang, B, Peng
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NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells [PDF]
Cell, 2008 Quiescent adult stem cells reside in specialized niches where they become activated to proliferate and differentiate during tissue homeostasis and injury. How stem cell quiescence is governed is poorly understood. We report here that NFATc1 is preferentially expressed by hair follicle stem cells in their niche, where its expression is activated by BMP ...
Valerie Horsley +2 more
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Regulatory mechanism of NFATc1 in RANKL‐induced osteoclast activation [PDF]
FEBS Letters, 2009 NFATc1 is a master regulator of RANKL‐induced osteoclast differentiation and herein we investigate the regulatory mechanism of NFATc1 in osteoclast activation. Inactivation of NFATc1 strongly attenuates RANKL‐induced bone resorption and overexpression of a constitutively active form of NFATc1 in osteoclasts induces formation of actin rings and ...
Song, Insun +5 more
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NFATc1 in Inflammatory and Musculoskeletal Conditions
2009The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell ...
Antonios O, Aliprantis +1 more
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Retinoic acid inhibits NFATc1 expression and osteoclast differentiation
Journal of Bone and Mineral Metabolism, 2011Ingestion of excess vitamin A appears to correlate with an increased fracture risk, an outcome that is likely mediated by retinoic acids (RAs); these are vitamin A metabolites that have dramatic effects on skeletal development. We studied the impacts of RA and isoform-specific RA receptor (RAR) agonists (α, β, and γ) on osteoclast formation ...
Wayne, Balkan +4 more
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NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis
Annals of the New York Academy of Sciences, 2006Abstract: Bone loss and osteoporosis are major public health problems in the elderly. With increasing life expectancy in the United States, the number of people that will develop age‐related bone loss and osteoporosis is expected to rise to over 61 million by 2020.
Hyeonju, Yeo +2 more
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NFATc1 autoregulation: a crucial step for cell-fate determination
Trends in Immunology, 2006Nuclear factor of activated T cell c (NFATc) transcription factors appeared in evolution with the emergence of lymphocytes in jawed fish. They have decisive roles in the development of the immune system and adaptive immune responses. Following immunoreceptor stimulation, NFAT factors control the expression of a large set of genes and thereby the fate ...
Edgar, Serfling +4 more
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Noncanonical NFATc1 activation in DN thymocytes
Nature Immunology, 2013Double-negative (DN) thymocytes depend on interleukin 7 (IL-7) for survival. In DN2 and DN3 cells, a new role has now been identified for signaling via the IL-7 receptor and the kinase Jak3 that leads to noncanonical activation of the transcription factor NFATc1 and upregulation of expression of the antiapoptotic protein Bcl-2.
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