Results 191 to 200 of about 15,571 (214)

Pro-Homeostatic Effects of Estrogen on Intraocular Pressure and the Trabecular Meshwork. [PDF]

Invest Ophthalmol Vis Sci
Youngblood HA, Cai J, Sun J, Elsayed OA, Yu H, Smith SB, Xu H, Pasquale LR, Stamer WD, Liu Y.   +9 more
europepmc   +1 more source

Decoding Epigenetic Switches: How Histone Acetylation/Deacetylation Regulates Mononuclear/Macrophage Fate in Bone Disorders. [PDF]

Int J Biol Sci
Xu L, Shen C, Liu X, Qin Y, Wu Z, Zhang Z, Sheng Q, Wang Q, Zhou F, Ge G, Geng D.   +10 more
europepmc   +1 more source

Regulatory mechanism of NFATc1 in RANKL‐induced osteoclast activation [PDF]

FEBS Letters, 2009
NFATc1 is a master regulator of RANKL‐induced osteoclast differentiation and herein we investigate the regulatory mechanism of NFATc1 in osteoclast activation. Inactivation of NFATc1 strongly attenuates RANKL‐induced bone resorption and overexpression of a constitutively active form of NFATc1 in osteoclasts induces formation of actin rings and ...
Song, Insun, Kim, Jung Ha, Kim, Kabsun, Jin, Hye Mi, Youn, Bang Ung, Kim, Nacksung   +5 more
exaly   +5 more sources

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NFATc1: Functions in osteoclasts

International Journal of Biochemistry and Cell Biology, 2010
NFATc1 is an important transcription factor which is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis, lymphatic endothelial development, osteoblast differentiation and osteoclastogenesis. Especially, it is a master regulator of RANKL-induced osteoclast differentiation and plays a pivotal role in osteoclast fusion ...
Ruokun Jia
exaly   +3 more sources

VEGF and RANKL Regulation of NFATc1 in Heart Valve Development [PDF]

Circulation Research, 2009
Rationale: NFATc1 (nuclear factor of activated T-cells cytoplasmic 1) activity in endocardial cushion (ECC) endothelial cells is required for normal ECC growth and extracellular matrix (ECM) remodeling during heart valve development. Objective:
Katherine Yutzey
exaly   +3 more sources

Critical role of NFATc1 in periapical lesions

International Endodontic Journal, 2010
Zhang C, Yang L, Peng B. Critical role of NFATc1 in periapical lesions. International Endodontic Journal, 43, 109–114, 2010.AbstractAim  To observe NFATc1 expression in experimental periapical lesions in rats.Methodology  Apical periodontitis was induced in Wistar rats by occlusal pulp exposure in mandibular first molar teeth.
C, Zhang, L, Yang, B, Peng
exaly   +3 more sources

NFATc1 in Inflammatory and Musculoskeletal Conditions

2009
The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell ...
Antonios O, Aliprantis, Laurie H, Glimcher   +1 more
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NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis

Annals of the New York Academy of Sciences, 2006
Abstract:  Bone loss and osteoporosis are major public health problems in the elderly. With increasing life expectancy in the United States, the number of people that will develop age‐related bone loss and osteoporosis is expected to rise to over 61 million by 2020.
Hyeonju, Yeo, Jay M, McDonald, Majd, Zayzafoon   +2 more
openaire   +2 more sources

NFATc1 autoregulation: a crucial step for cell-fate determination

Trends in Immunology, 2006
Nuclear factor of activated T cell c (NFATc) transcription factors appeared in evolution with the emergence of lymphocytes in jawed fish. They have decisive roles in the development of the immune system and adaptive immune responses. Following immunoreceptor stimulation, NFAT factors control the expression of a large set of genes and thereby the fate ...
Edgar, Serfling, Sergei, Chuvpilo, Jiming, Liu, Thomas, Höfer, Alois, Palmetshofer   +4 more
openaire   +2 more sources