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Uridine inhibits ROS-mediated osteoclast differentiation and alleviates osteoporosis via modulation of PI3K/Akt-FoxO signaling. [PDF]
Front ImmunolBian S +10 more
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Epigenetic Regulation of Bone Homeostasis in Osteoporosis: Mechanisms, Evidence Gaps, and Translational Prospects. [PDF]
Cell Biochem FunctDu M, Wang L.
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Limonoid 7-Deacetoxy-7-oxogedunin (CG-1) Attenuates RANKL-Induced Osteoclastogenesis via Inhibiting PI3K/Akt-NFATc1 Axis. [PDF]
CellsKoike A, Fujimori K.
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Targeting RANKL-independent osteoclastogenesis overcomes denosumab resistance in models of ER+ breast cancer bone metastasis. [PDF]
J Clin InvestLin Q +16 more
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Critical Role of NFATc1 in Periapical Lesions
International Endodontic Journal, 2010Zhang C, Yang L, Peng B. Critical role of NFATc1 in periapical lesions. International Endodontic Journal, 43, 109–114, 2010.AbstractAim To observe NFATc1 expression in experimental periapical lesions in rats.Methodology Apical periodontitis was induced in Wistar rats by occlusal pulp exposure in mandibular first molar teeth.
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NFATc1: Functions in Osteoclasts
International Journal of Biochemistry and Cell Biology, 2010NFATc1 is an important transcription factor which is critical for lineage selection in T-cell differentiation, cardiac valve morphogenesis, lymphatic endothelial development, osteoblast differentiation and osteoclastogenesis. Especially, it is a master regulator of RANKL-induced osteoclast differentiation and plays a pivotal role in osteoclast fusion ...
Qingxiao, Zhao +4 more
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