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Regulatory Mechanism of NFATc1 in RANKL-Induced Osteoclast Activation [PDF]
FEBS Letters, 2009 NFATc1 is a master regulator of RANKL‐induced osteoclast differentiation and herein we investigate the regulatory mechanism of NFATc1 in osteoclast activation. Inactivation of NFATc1 strongly attenuates RANKL‐induced bone resorption and overexpression of a constitutively active form of NFATc1 in osteoclasts induces formation of actin rings and ...
Nacksung Kim, Bang Ung Youn, Hye Mi Jin
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VEGF and RANKL Regulation of NFATc1 in Heart Valve Development [PDF]
Circulation Research, 2009 Rationale: NFATc1 (nuclear factor of activated T-cells cytoplasmic 1) activity in endocardial cushion (ECC) endothelial cells is required for normal ECC growth and extracellular matrix (ECM) remodeling during heart valve development. Objective:
Katherine E. Yutzey
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NFATc1 in Inflammatory and Musculoskeletal Conditions
2009The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell ...
Antonios O, Aliprantis +1 more
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NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis
Annals of the New York Academy of Sciences, 2006Abstract: Bone loss and osteoporosis are major public health problems in the elderly. With increasing life expectancy in the United States, the number of people that will develop age‐related bone loss and osteoporosis is expected to rise to over 61 million by 2020.
Hyeonju, Yeo +2 more
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Homer 2 Regulates Muscle Differentiation with NFATc1
Cells Tissues OrgansIntroduction: Calcineurin-NFAT is an important pathway that regulates skeletal muscle regeneration. Homer 2 that modulates signal transduction in the central nervous system directly binds to NFATc1. However, its role is not fully understood in skeletal muscle regeneration.
Miki, Aizawa +2 more
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NFATc1 autoregulation: a crucial step for cell-fate determination
Trends in Immunology, 2006Nuclear factor of activated T cell c (NFATc) transcription factors appeared in evolution with the emergence of lymphocytes in jawed fish. They have decisive roles in the development of the immune system and adaptive immune responses. Following immunoreceptor stimulation, NFAT factors control the expression of a large set of genes and thereby the fate ...
Edgar, Serfling +4 more
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Noncanonical NFATc1 activation in DN thymocytes
Nature Immunology, 2013Double-negative (DN) thymocytes depend on interleukin 7 (IL-7) for survival. In DN2 and DN3 cells, a new role has now been identified for signaling via the IL-7 receptor and the kinase Jak3 that leads to noncanonical activation of the transcription factor NFATc1 and upregulation of expression of the antiapoptotic protein Bcl-2.
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NFATC1 modulation of atrial excitability in zebrafish
Biophysical Journal, 2023Natalia S. Torres +3 more
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