Results 1 to 10 of about 31,404 (249)

ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review

Biomolecules, 2023
Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by the accumulation of unfolded and misfolded proteins. During osteoclastogenesis, a large number of active proteins are synthesized. When an
Yining Gong, Liang Yan
exaly   +3 more sources

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

Frontiers in Pharmacology, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun, Wugui Chen, Songtao Li, Sizhen Yang, Ying Zhang, Xu Hu, Hao Qiu, Jigong Wu, Shangcheng Xu, Tongwei Chu   +9 more
doaj   +1 more source

Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner. [PDF]

PLoS ONE, 2012
Infection of macrophages with bacteria induces the production of pro-inflammatory cytokines including TNF-α. TNF-α directly stimulates osteoclast differentiation from bone marrow macrophages in vitro as well as indirectly via osteoblasts.
Akiko Kukita, Yuka Ichigi, Ippei Takigawa, Toshiyuki Watanabe, Toshio Kukita, Hiroshi Miyamoto   +5 more
doaj   +1 more source

Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice

Journal of Orthopaedic Translation, 2021
Background: Hepatocyte growth factor (HGF) is a multifunctional growth factor that promotes various biological processes. However, the effect of HGF on bone metabolism in rheumatoid arthritis (RA) remains unknown. Here, we investigated the role of HGF in
Chaoming Huang, Yufan Zheng, Jinyu Bai, Ce Shi, Xin Shi, Huajian Shan, Xiaozhong Zhou   +6 more
doaj   +1 more source

Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-κB and MAPK signaling pathways

Journal of Pharmacological Sciences, 2021
Aims: To investigate the effect of dencichine on osteoclastogenesis in vivo and in vitro. Methods: RANKL-induced osteoclastogenesis were treated with different concentrations of dencichine.
Dingwei Cang, Guoyou Zou, Chi Yang, Xiaofei Shen, Feng Li, Ya Wu, Biao Ji   +6 more
doaj   +1 more source

Sec-O-Glucosylhamaudol Inhibits RANKL-Induced Osteoclastogenesis by Repressing 5-LO and AKT/GSK3β Signaling

Frontiers in Immunology, 2022
Sec-O-glucosylhamaudol (SOG), an active flavonoid compound derived from the root of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk., exhibits analgesic, anti-inflammatory, and high 5-lipoxygenase (5-LO) inhibitory effects.
Jinjin Cao, Ming-Xue Zhou, Xinyan Chen, Menglu Sun, Congmin Wei, Qisheng Peng, Zhou Cheng, Wanchun Sun, Hongbing Wang   +8 more
doaj   +1 more source

In vitro osteoclastogenesis in autoimmune diseases – Strengths and pitfalls of a tool for studying pathological bone resorption and other disease characteristics

Heliyon, 2023
Osteoclasts play a critical role in bone pathology frequently associated with autoimmune diseases. Studying the etiopathogenesis of these diseases and their clinical manifestations can involve in vitro osteoclastogenesis, an experimental technique that ...
Patrik Skubica, Marketa Husakova, Pavlina Dankova   +2 more
doaj   +1 more source

Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia

Journal of Pharmacological Sciences, 2022
Osteoporosis is caused by an imbalance in bone remodeling due to abnormal osteoclast (OC) formation and activation. Hypoxia at the site of inflammation promotes OC formation and activation in various species, including humans. We previously reported that
Takao Kondo, Hiromasa Aoki, Yuto Otsuka, Yohei Kawaguchi, Yuko Waguri-Nagaya, Mineyoshi Aoyama   +5 more
doaj   +1 more source

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
doaj   +1 more source

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

Frontiers in Pharmacology, 2020
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao   +10 more
doaj   +1 more source