Results 11 to 20 of about 53,100 (272)

THOC5 regulates human osteoclastogenesis

European Journal of Cell Biology, 2022
Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of macrophages and osteoclasts.
Se Hwan Mun, Brian Oh, Min Joon Lee, Seyeon Bae, Young Yang, Kyung-Hyun Park-Min   +5 more
openaire   +3 more sources

Apremilast inhibits inflammatory osteoclastogenesis

Rheumatology, 2021
Abstract Objectives Psoriatic arthritis (PsA) is associated with bone erosion and inflammation-induced bone loss, which are mediated by osteoclasts (OC) and modulated by inflammatory cytokines. Apremilast (APR) (a selective phosphodiesterase 4 inhibitor) is efficacious in PsA and acts by inhibiting ...
Yannick Degboé, Flavia Sunzini, Shatakshi Sood, Aline Bozec, Maria V Sokolova, Ana Zekovic, Iain B McInnes, Georg Schett, Carl S Goodyear   +8 more
openaire   +2 more sources

Bortezomib inhibits human osteoclastogenesis [PDF]

Leukemia, 2007
In multiple myeloma, the overexpression of receptor activator of nuclear factor kappa B (NF-kappaB) ligand (RANKL) leads to the induction of NF-kappaB and activator protein-1 (AP-1)-related osteoclast activation and enhanced bone resorption. The purpose of this study was to examine the molecular and functional effects of proteasome inhibition in RANKL ...
I, von Metzler, H, Krebbel, M, Hecht, R A, Manz, C, Fleissner, M, Mieth, M, Kaiser, C, Jakob, J, Sterz, L, Kleeberg, U, Heider, O, Sezer   +11 more
openaire   +2 more sources

In vitro osteoclastogenesis in autoimmune diseases – Strengths and pitfalls of a tool for studying pathological bone resorption and other disease characteristics

Heliyon, 2023
Osteoclasts play a critical role in bone pathology frequently associated with autoimmune diseases. Studying the etiopathogenesis of these diseases and their clinical manifestations can involve in vitro osteoclastogenesis, an experimental technique that ...
Patrik Skubica, Marketa Husakova, Pavlina Dankova   +2 more
doaj   +1 more source

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

Frontiers in Pharmacology, 2020
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao   +10 more
doaj   +1 more source

Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634

Journal of Orthopaedic Translation, 2022
Background: Ankylosing spondylitis (AS) is featured by chronic inflammation of the sacroiliac joints and spine as well as pathological new bone formation. Osteoclastogenesis is a critical part in the development of bone formation. Circular RNAs (circRNAs)
Wei Ji, Yueyang Lu, Zhuoyi Ma, Ke Gan, Yan Liu, Yue Cheng, Junliang Xu, Shijia Liu, Yunke Guo, Shanhang Han, Zengyan Zhao, Hanmei Xu, Weiyan Qi   +12 more
doaj   +1 more source

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss

Frontiers in Pharmacology, 2021
Osteoporosis is characterized by bone loss and destruction of trabecular architecture, which greatly increases the burden on the healthcare system.
Dahu Qi, Hui Liu, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao   +10 more
doaj   +1 more source

Osteoclastogenesis and Osteogenesis

International Journal of Molecular Sciences, 2022
Bone is a highly dynamic tissue that is continuously remodeled to attain and maintain optimal bone integrity, mass, and strength [...]
openaire   +2 more sources

p38α MAPK regulates proliferation and differentiation of osteoclast progenitors and bone remodeling in an aging-dependent manner. [PDF]

, 2017
Bone mass is determined by the balance between bone formation, carried out by mesenchymal stem cell-derived osteoblasts, and bone resorption, carried out by monocyte-derived osteoclasts.
Ao, Junping, Cong, Qian, Jia, Hao, Li, Baojie, Li, Ping, Liu, Huijuan, Qiu, Shoutao, Wang, Yibin, Yeh, James, Zhang, Zhen-Lin   +9 more
core   +1 more source