Results 11 to 20 of about 36,147 (282)

ER Stress, the Unfolded Protein Response and Osteoclastogenesis: A Review

Biomolecules, 2023
Endoplasmic reticulum (ER) stress and its adaptive mechanism, the unfolded protein response (UPR), are triggered by the accumulation of unfolded and misfolded proteins. During osteoclastogenesis, a large number of active proteins are synthesized. When an
Yining Gong, Liang Yan, Gong Yining
exaly   +4 more sources

Porphyromonas gingivalis-derived extracellular vesicles aggravate bone destruction in rheumatoid arthritis by promoting Syk-dependent osteoclastogenesis [PDF]

International Journal of Oral Science
Rheumatoid arthritis (RA) is an autoimmune disorder that triggers progressive joint destruction by inducing excessive osteoclastogenesis. Porphyromonas gingivalis (Pg), the main pathogenic bacterium involved in periodontitis (PD), is closely related to ...
Jiajie Guo, Qiujing Qiu, Xiaoyuan Yan, Zeying Zhang, Xiyue Zhang, Na An, Chengcheng Yin, Di Yang, Hirohiko Okamura, Kaya Yoshida, Hongchen Sun, Lihong Qiu   +11 more
doaj   +2 more sources

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +2 more sources

CD109 Plays a Role in Osteoclastogenesis

PLoS ONE, 2013
Osteoclasts are large multinucleated cells that arise from the fusion of cells from the monocyte/macrophage lineage. Osteoclastogenesis is mediated by macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor-kB ligand (RANKL) and involves a complex multistep process that requires numerous other elements, many of which ...
Wang, Yongqiang, Inger, Maayan, Jiang, Hongwei, Tenenbaum, Howard, Glogauer, Michael   +4 more
openaire   +7 more sources

A microRNA expression signature of osteoclastogenesis

Blood, 2011
AbstractMicroRNAs (miRs) are small noncoding RNAs that principally function in the spatiotemporal regulation of protein translation in animal cells. Although emerging evidence suggests that some miRs play important roles in osteoblastogenesis and skeletal homeostasis, much less is known in osteoclastogenesis.
Toshifumi, Sugatani, Jean, Vacher, Keith A, Hruska   +2 more
openaire   +4 more sources

Caffeic Acid Inhibits NFkappaB Activation of Osteoclastogenesis Signaling Pathway

Indonesian Biomedical Journal, 2011
BACKGROUND: Caffeic acid (3,4-dihydroxycinnamic acids) is involved in various green plants. Based on our previous report, a major component of sweet potato extracts, possibly caffeic acid, was shown as a promising inhibitor of osteoclastogenesis. However,
Ferry Sandra, Toshio Kukita, Quan Yong Tang, Tadahiko Iijima   +3 more
doaj   +3 more sources

Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway

Frontiers in Pharmacology, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun, Wugui Chen, Songtao Li, Sizhen Yang, Ying Zhang, Xu Hu, Hao Qiu, Jigong Wu, Shangcheng Xu, Tongwei Chu   +9 more
doaj   +1 more source

Acid Dentin Lysate Modulates Macrophage Polarization and Osteoclastogenesis In Vitro. [PDF]

, 2021
Dentin prepared from extracted teeth is used as autograft for alveolar bone augmentation. Graft consolidation involves the acid lysis of dentin thereby generating a characteristic paracrine environment. Acid lysate of dentin is mimicking this environment.
Gruber, Reinhard, Nasirzade, Jila, Reinhard Gruber, Jila Nasirzade, Panahipour, Layla, Zahra Kargarpour, Kargarpour, Zahra, Layla Panahipour   +7 more
core   +1 more source

Dencichine prevents ovariectomy-induced bone loss and inhibits osteoclastogenesis by inhibiting RANKL-associated NF-κB and MAPK signaling pathways

Journal of Pharmacological Sciences, 2021
Aims: To investigate the effect of dencichine on osteoclastogenesis in vivo and in vitro. Methods: RANKL-induced osteoclastogenesis were treated with different concentrations of dencichine.
Dingwei Cang, Guoyou Zou, Chi Yang, Xiaofei Shen, Feng Li, Ya Wu, Biao Ji   +6 more
doaj   +1 more source

Hepatocyte growth factor overexpression promotes osteoclastogenesis and exacerbates bone loss in CIA mice

Journal of Orthopaedic Translation, 2021
Background: Hepatocyte growth factor (HGF) is a multifunctional growth factor that promotes various biological processes. However, the effect of HGF on bone metabolism in rheumatoid arthritis (RA) remains unknown. Here, we investigated the role of HGF in
Chaoming Huang, Yufan Zheng, Jinyu Bai, Ce Shi, Xin Shi, Huajian Shan, Xiaozhong Zhou   +6 more
doaj   +1 more source