Results 11 to 20 of about 31,404 (249)

Hierarchical Nanoplatform Integrating Oxidative-Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy. [PDF]

Adv Sci (Weinh)
A hierarchical CM/LDH nanoplatform integrates ROS‐scavenging Ce‐MOF nanozymes with acid‐neutralizing CaAl‐LDH and is delivered within GelMA hydrogel to diabetic bone defects. By remodeling the oxidative‐acidic microenvironment, preserving mitochondrial homeostasis, and suppressing mtDNA–cGAS–STING inflammatory signaling, CM/LDH reduces proinflammatory ...
Chen X, Zhu X, Qiu Z, Zhu Y, Zheng X, Fan D, Zhan J, Mao C, Ji P, Chen T, He Q.   +10 more
europepmc   +2 more sources

Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK-Binding Osteoclastogenic Factor. [PDF]

Adv Sci (Weinh)
Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Park C, Kwon Y, Lim Y, Park JW, Ji HJ, Lee D, Lee J, Yun SH, Jeong S, Seo HS, Cho K, Yun CH, Park OJ, Han SH.   +13 more
europepmc   +2 more sources

Thioredoxin-2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation. [PDF]

Adv Sci (Weinh)
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Zhan C, Zhou Z, Ding Y, Lian R, Li X, Zhang X, Cao J, Tang Z, Lin Z, Song Z, He F.   +10 more
europepmc   +2 more sources

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources

Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634

Journal of Orthopaedic Translation, 2022
Background: Ankylosing spondylitis (AS) is featured by chronic inflammation of the sacroiliac joints and spine as well as pathological new bone formation. Osteoclastogenesis is a critical part in the development of bone formation. Circular RNAs (circRNAs)
Wei Ji, Yueyang Lu, Zhuoyi Ma, Ke Gan, Yan Liu, Yue Cheng, Junliang Xu, Shijia Liu, Yunke Guo, Shanhang Han, Zengyan Zhao, Hanmei Xu, Weiyan Qi   +12 more
doaj   +1 more source

Osteoclastogenesis and Osteogenesis

International Journal of Molecular Sciences, 2022
Bone is a highly dynamic tissue that is continuously remodeled to attain and maintain optimal bone integrity, mass, and strength [...]
openaire   +2 more sources

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss

Frontiers in Pharmacology, 2021
Osteoporosis is characterized by bone loss and destruction of trabecular architecture, which greatly increases the burden on the healthcare system.
Dahu Qi, Hui Liu, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao   +10 more
doaj   +1 more source

Bortezomib inhibits human osteoclastogenesis [PDF]

Leukemia, 2007
In multiple myeloma, the overexpression of receptor activator of nuclear factor kappa B (NF-kappaB) ligand (RANKL) leads to the induction of NF-kappaB and activator protein-1 (AP-1)-related osteoclast activation and enhanced bone resorption. The purpose of this study was to examine the molecular and functional effects of proteasome inhibition in RANKL ...
I, von Metzler, H, Krebbel, M, Hecht, R A, Manz, C, Fleissner, M, Mieth, M, Kaiser, C, Jakob, J, Sterz, L, Kleeberg, U, Heider, O, Sezer   +11 more
openaire   +2 more sources

Osteoclastogenesis and osteoimmunology

Frontiers in Bioscience, 2014
Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts (bone resorption) and osteoblasts (bone formation). Bone resorption is an elementary cellular activity in the modeling of the skeleton during growth and development ...
Wei, Feng, Wei, Xia, Qing, Ye, Weibing, Wu   +3 more
openaire   +2 more sources

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +1 more source