Results 21 to 30 of about 53,100 (272)

Blocking FSH action attenuates osteoclastogenesis [PDF]

Biochemical and Biophysical Research Communications, 2012
A direct effect of FSH on bone turnover via stimulation of osteoclast formation has been reported. Here we show that monoclonal or polyclonal antibodies to FSH inhibit osteoclast formation induced by FSH to an extent similar to that noted in FSH receptor (FSHR) knockout cells.
Ling-Ling, Zhu, Irina, Tourkova, Tony, Yuen, Lisa J, Robinson, Zhuan, Bian, Mone, Zaidi, Harry C, Blair   +6 more
openaire   +2 more sources

Glycosaminoglycans modulate RANKL‐induced osteoclastogenesis [PDF]

Journal of Cellular Biochemistry, 2010
AbstractSkeletal integrity is tightly regulated by the activity of osteoblasts and osteoclasts that are both under the control of extracellular glycosaminoglycans (GAGs) through their interactions with endogenous growth factors and differentiation‐promoting ligands. Receptor activator of NF‐kappa‐B ligand (RANKL), which is a tumor necrosis factor (TNF)‐
Ling, Ling, Murali, Sadasivam, Stein, Gary S., Van Wijnen, Andre J., Cool, Simon M.   +4 more
openaire   +3 more sources

Molecular mechanism of thiazolidinedione-mediated inhibitory effects on osteoclastogenesis.

PLoS ONE, 2014
Thiazolidinediones are synthetic peroxisome proliferator-activated receptor γ agonists used to treat type 2 diabetes mellitus. Clinical evidence indicates that thiazolidinediones increase fracture risks in type 2 diabetes mellitus patients, but the ...
Dongfeng Zhao, Zhenqi Shi, Amy H Warriner, Ping Qiao, Huixian Hong, Yongjun Wang, Xu Feng   +6 more
doaj   +1 more source

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis. [PDF]

, 2017
Histamine H4 receptor (H4R) has immune-modulatory and chemotaxic effects in various immune cells. This study aimed to determine the osteoclastogenic role of H4R in rheumatoid arthritis (RA).
Firestein, Gary S, Kim, Bo-Mi, Kim, Hae-Rim, Kim, Kyoung-Woon, Lee, Kyung-Ann, Lee, Sang-Heon   +5 more
core   +1 more source

Osteoclastogenesis and osteoimmunology

Frontiers in Bioscience, 2014
Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts (bone resorption) and osteoblasts (bone formation). Bone resorption is an elementary cellular activity in the modeling of the skeleton during growth and development ...
Wei, Feng, Wei, Xia, Qing, Ye, Weibing, Wu   +3 more
openaire   +2 more sources

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

Arthritis Research & Therapy, 2016
Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.The presence of nAChR subunits as well as the in-vitro effects of nAChR agonists were investigated by ex vivo osteoclastogenesis assays, real-time polymerase chain reaction, Western blot and flow cytometry in ...
Mandl P, Hayer S, Karonitsch T, Scholze P, Győri, Dávid Sándor, Sykoutri D, Blüml S, Mócsai, Attila, Poór, Gyula, Huck S, Smolen JS, Redlich K   +11 more
openaire   +3 more sources

Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis

Journal of Orthopaedic Translation, 2022
Background/objective: Subchondral bone marrow lesions (BMLs) are common magnetic resonance imaging (MRI) features in joints affected by osteoarthritis (OA), however, their clinical impacts and mechanisms remain controversial.
Feng Zhou, Xuequan Han, Liao Wang, Weituo Zhang, Junqi Cui, Zihao He, Kai Xie, Xu Jiang, Jingke Du, Songtao Ai, Qi Sun, Haishan Wu, Zhifeng Yu, Mengning Yan   +13 more
doaj   +1 more source

Osteoclastogenesis-Related Antigen, a Novel Molecule on Mouse Stromal Cells, Regulates Osteoclastogenesis [PDF]

Journal of Bone and Mineral Research, 2003
Abstract Osteoclastogenesis is regulated by RANKL expressed on stromal cells. In this study, we sought to isolate a new surface molecule regulating osteoclastogenesis on stromal cells by generating monoclonal antibodies. A rat was immunized with the mouse stromal cell line, TSB13, which can support osteoclastogenesis, and a monoclonal ...
Satoshi, Arai, Norio, Amizuka, Yoshiaki, Azuma, Sunao, Takeshita, Akira, Kudo   +4 more
openaire   +2 more sources

Preliminary Report: Osteoarthritis and Rheumatoid Arthritis Synovial Fluid Increased Osteoclastogenesis In Vitro by Monocyte Differentiation Pathway Regulating Cytokines

Mediators of Inflammation, 2022
Background. Rheumatoid arthritis (RA) and osteoarthritis (OA) are common joint diseases associated with changes in local, as well as systemic bone structure and osteoclast function.
Jani Luukkonen, Johanna Huhtakangas, Sanna Palosaari, Juha Tuukkanen, Olli Vuolteenaho, Petri Lehenkari   +5 more
doaj   +1 more source

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]

, 2013
Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core   +1 more source