Results 21 to 30 of about 36,147 (282)

Flavonoids from Dalbergia cochinchinensis: Impact on osteoclastogenesis. [PDF]

, 2023
BACKGROUND/PURPOSE Dalbergia cochinchinensi has been widely used in traditional medicine because of its flavonoids. This study examined which components in D. cochinchinensis were capable of reducing or even stimulating the formation of bone-resorbing
Gruber, Reinhard, Shao, Feng, Panahipour, Layla   +2 more
core   +1 more source

Infection of RANKL-primed RAW-D macrophages with Porphyromonas gingivalis promotes osteoclastogenesis in a TNF-α-independent manner. [PDF]

PLoS ONE, 2012
Infection of macrophages with bacteria induces the production of pro-inflammatory cytokines including TNF-α. TNF-α directly stimulates osteoclast differentiation from bone marrow macrophages in vitro as well as indirectly via osteoblasts.
Akiko Kukita, Yuka Ichigi, Ippei Takigawa, Toshiyuki Watanabe, Toshio Kukita, Hiroshi Miyamoto   +5 more
doaj   +1 more source

Sec-O-Glucosylhamaudol Inhibits RANKL-Induced Osteoclastogenesis by Repressing 5-LO and AKT/GSK3β Signaling

Frontiers in Immunology, 2022
Sec-O-glucosylhamaudol (SOG), an active flavonoid compound derived from the root of Saposhnikovia divaricata (Turcz. ex Ledeb.) Schischk., exhibits analgesic, anti-inflammatory, and high 5-lipoxygenase (5-LO) inhibitory effects.
Jinjin Cao, Ming-Xue Zhou, Xinyan Chen, Menglu Sun, Congmin Wei, Qisheng Peng, Zhou Cheng, Wanchun Sun, Hongbing Wang   +8 more
doaj   +1 more source

Osteocyte control of osteoclastogenesis [PDF]

Bone, 2013
Multiple lines of evidence support the idea that osteocytes act as mechanosensors in bone and that they control bone formation, in part, by expressing the Wnt antagonist sclerostin. However, the role of osteocytes in the control of bone resorption has been less clear. Recent studies have demonstrated that osteocytes are the major source of the cytokine
Charles A, O'Brien, Tomoki, Nakashima, Hiroshi, Takayanagi   +2 more
openaire   +2 more sources

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
doaj   +1 more source

Liquid PRF Reduces the Inflammatory Response and Osteoclastogenesis in Murine Macrophages. [PDF]

, 2021
Macrophage activation and osteoclastogenesis are hallmarks of inflammatory osteolysis and may be targeted by the local application of liquid platelet-rich fibrin (PRF).
Gruber, Reinhard, Nasirzade, Jila, Miron, Richard J., Panahipour, Layla, Kargarpour, Zahra   +4 more
core   +1 more source

Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia

Journal of Pharmacological Sciences, 2022
Osteoporosis is caused by an imbalance in bone remodeling due to abnormal osteoclast (OC) formation and activation. Hypoxia at the site of inflammation promotes OC formation and activation in various species, including humans. We previously reported that
Takao Kondo, Hiromasa Aoki, Yuto Otsuka, Yohei Kawaguchi, Yuko Waguri-Nagaya, Mineyoshi Aoyama   +5 more
doaj   +1 more source

In vitro osteoclastogenesis in autoimmune diseases – Strengths and pitfalls of a tool for studying pathological bone resorption and other disease characteristics

Heliyon, 2023
Osteoclasts play a critical role in bone pathology frequently associated with autoimmune diseases. Studying the etiopathogenesis of these diseases and their clinical manifestations can involve in vitro osteoclastogenesis, an experimental technique that ...
Patrik Skubica, Marketa Husakova, Pavlina Dankova   +2 more
doaj   +1 more source

Myostatin Promotes Osteoclastogenesis by Regulating Ccdc50 Gene Expression and RANKL-Induced NF-κB and MAPK Pathways

Frontiers in Pharmacology, 2020
Myostatin is a crucial cytokine that is widely present in skeletal muscle and that negatively regulates the growth and development of muscle cells. Recent research has shown that myostatin might play an essential role in bone metabolism.
Xin Zhi, Qian Chen, Shaojun Song, Zhengrong Gu, Wenqiang Wei, Huiwen Chen, Xiao Chen, Weizong Weng, Qirong Zhou, Jin Cui, Liehu Cao   +10 more
doaj   +1 more source

Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634

Journal of Orthopaedic Translation, 2022
Background: Ankylosing spondylitis (AS) is featured by chronic inflammation of the sacroiliac joints and spine as well as pathological new bone formation. Osteoclastogenesis is a critical part in the development of bone formation. Circular RNAs (circRNAs)
Wei Ji, Yueyang Lu, Zhuoyi Ma, Ke Gan, Yan Liu, Yue Cheng, Junliang Xu, Shijia Liu, Yunke Guo, Shanhang Han, Zengyan Zhao, Hanmei Xu, Weiyan Qi   +12 more
doaj   +1 more source