Results 41 to 50 of about 36,147 (282)

Associations of osteoclastogenesis and nerve growth in subchondral bone marrow lesions with clinical symptoms in knee osteoarthritis

Journal of Orthopaedic Translation, 2022
Background/objective: Subchondral bone marrow lesions (BMLs) are common magnetic resonance imaging (MRI) features in joints affected by osteoarthritis (OA), however, their clinical impacts and mechanisms remain controversial.
Feng Zhou, Xuequan Han, Liao Wang, Weituo Zhang, Junqi Cui, Zihao He, Kai Xie, Xu Jiang, Jingke Du, Songtao Ai, Qi Sun, Haishan Wu, Zhifeng Yu, Mengning Yan   +13 more
doaj   +1 more source

Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis

Cell Death and Disease, 2021
Enhanced osteoclastogenesis is one of the major causes of age-related bone loss. Aging is accompanied by accumulation of advanced oxidation protein products (AOPPs).
Jingshen Zhuang, Xuebing Chen, Guixing Cai, Dizheng Wu, Chen Tu, Siyuan Zhu, Yusheng Huang, Ping Xu, Zhaoming Zhong   +8 more
doaj   +1 more source

Mechanisms of Enhanced Osteoclastogenesis in Alkaptonuria [PDF]

The American Journal of Pathology, 2018
Alkaptonuria (AKU) is a rare disorder characterized by the deficiency of the enzyme homogentisate 1,2-dioxygenase and consequent homogentisate accumulation, which leads to progressive and severe osteoarthopathy starting from the second decade of life. Thus, in AKU patients, bone involvement represents an important clinical issue, which we investigated.
Giacomina Brunetti, Albina Tummolo, Gabriele D'Amato, Alberto Gaeta, Federica Ortolani, Laura Piacente, Paola Giordano, Silvia Colucci, Maria Grano, Francesco Papadia, Maria F. Faienza   +10 more
openaire   +3 more sources

Preliminary Report: Osteoarthritis and Rheumatoid Arthritis Synovial Fluid Increased Osteoclastogenesis In Vitro by Monocyte Differentiation Pathway Regulating Cytokines

Mediators of Inflammation, 2022
Background. Rheumatoid arthritis (RA) and osteoarthritis (OA) are common joint diseases associated with changes in local, as well as systemic bone structure and osteoclast function.
Jani Luukkonen, Johanna Huhtakangas, Sanna Palosaari, Juha Tuukkanen, Olli Vuolteenaho, Petri Lehenkari   +5 more
doaj   +1 more source

Apremilast inhibits inflammatory osteoclastogenesis

Rheumatology, 2021
Abstract Objectives Psoriatic arthritis (PsA) is associated with bone erosion and inflammation-induced bone loss, which are mediated by osteoclasts (OC) and modulated by inflammatory cytokines. Apremilast (APR) (a selective phosphodiesterase 4 inhibitor) is efficacious in PsA and acts by inhibiting ...
Yannick Degboé, Flavia Sunzini, Shatakshi Sood, Aline Bozec, Maria V Sokolova, Ana Zekovic, Iain B McInnes, Georg Schett, Carl S Goodyear   +8 more
openaire   +2 more sources

All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity

Cell & Bioscience, 2018
Background Bone regenerative heterodimeric bone morphogenetic protein 2/7 (BMP2/7) enhances but all-trans retinoic acid (ATRA) inhibits osteoclastogenesis.
Wenjuan Bi, Yi Liu, Jing Guo, Zhen Lin, Jinsong Liu, Miao Zhou, Daniel Wismeijer, Janak L. Pathak, Gang Wu   +8 more
doaj   +1 more source

Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo

Acta Biochimica et Biophysica Sinica, 2022
Osteoporosis deteriorates bone mass and biomechanical strength and is life-threatening to the elderly. In this study, we show that methyl 3,4-dihydroxybenzoate (MDHB), an antioxidant small-molecule compound extracted from natural plants, inhibits ...
Huang Zhaobo, Jiang Zenghui, Zheng Zeyu, Zhang Xuyang, Wei Xiaoan, Chen Jian, Zhao Fengdong   +6 more
doaj   +1 more source

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

Pharmaceutics, 2023
Curcuminoids, namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are the major active compounds found in Curcuma longa L. (turmeric).
Sompot Jantarawong, Piyawut Swangphon, Natda Lauterbach, Pharkphoom Panichayupakaranant, Yutthana Pengjam   +4 more
doaj   +1 more source

THOC5 regulates human osteoclastogenesis

European Journal of Cell Biology, 2022
Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of macrophages and osteoclasts.
Se Hwan Mun, Brian Oh, Min Joon Lee, Seyeon Bae, Young Yang, Kyung-Hyun Park-Min   +5 more
openaire   +3 more sources

Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation

Bone Reports, 2019
Osteoporosis is a disease that impacts over 200 million people worldwide. Taking into consideration the side effects stemming from medications used to treat this illness, investigators have increased their efforts to develop novel therapeutics for ...
Darin Quach, Narayanan Parameswaran, Laura McCabe, Robert A. Britton   +3 more
doaj   +1 more source