Results 51 to 60 of about 36,147 (282)
Cells, 2021 Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells.
So-Yeon Kim +4 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Osteoporosis is a condition associated with osteolytic bone disease that is primarily characterized by inordinate osteoclast activation. Protein kinase B (Akt) pathways activated by receptor activator of nuclear factor kappa-B ligand (RANKL) are ...
Mingming Dong +5 more
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Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis
Frontiers in Pharmacology, 2020 Postmenopausal osteoporosis (PMOP) is a metabolic bone disease characterized by decreased bone density and strength due to the imbalance between osteogenesis and osteoclastogenesis.
Zeyuan Zhong +8 more
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RARγ is a negative regulator of osteoclastogenesis
The Journal of Steroid Biochemistry and Molecular Biology, 2015 Vitamin A is known to influence post-natal bone content, with excess intake being associated with reduced bone mineral density and increased fracture risk. Despite this, the roles retinoids play in regulating osteoclastogenesis, particularly in vivo, remain unresolved.
Alanna C. Green +11 more
openaire +4 more sources
The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis
, 2013 Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Stefanie Herkt +11 more
core +1 more source
Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression.
Bone Reports, 2019 Bone destructive diseases such as periodontitis and rheumatoid arthritis are caused by excessive activation of osteoclasts. Osteoclastogenesis is regulated by Receptor activator of nuclear factor kappa-β ligand (RANKL) produced by osteoclastogenesis ...
Tsuyoshi Narimiya +6 more
doaj +1 more source
Clinical Oral Investigations / Inhibitory effect of saliva on osteoclastogenesis in vitro requires toll-like receptor 4 signaling [PDF]
, 2017 Objectives Saliva can suppress osteoclastogenesis, but the underlying mechanism has not been discovered yet. Considering that endotoxins suppress osteoclastogenesis in bone marrow cultures and that saliva contains endotoxins, it was reasonable to ...
Gruber, Reinhard +8 more
core +1 more source
The Role of Calmodulin in the Regulation of Osteoclastogenesis [PDF]
Endocrinology, 2003 Calmodulin plays an important role in regulating the function of mature osteoclasts. However, its role in osteoclastogenesis has not been investigated. In the present study, we examined the role of calmodulin in osteoclastogenesis using in vivo and in vitro systems.
Liang, Zhang, Xu, Feng, Jay M, McDonald
openaire +2 more sources
Applied Sciences, 2023 Women going through menopause experience changes in their hormone levels, such as decreased estrogen secretion. Those changes can lead to weight gain and steatosis (fatty liver) due to abnormal lipid metabolism and bone turnover. Natural herbal medicines
Sangmin Lee +5 more
doaj +1 more source
Saliva suppresses osteoclastogenesis in murine bone marrow cultures.
, 2015 Saliva can reach mineralized surfaces in the oral cavity; however, the relationship between saliva and bone resorption is unclear. Herein, we examined whether saliva affects the process of osteoclastogenesis in vitro.
Gruber, Reinhard +5 more
core +1 more source