Results 31 to 40 of about 53,100 (272)

Methyl 3,4-dihydroxybenzoate inhibits RANKL-induced osteoclastogenesis via Nrf2 signaling in vitro and suppresses LPS-induced osteolysis and ovariectomy-induced osteoporosis in vivo

Acta Biochimica et Biophysica Sinica, 2022
Osteoporosis deteriorates bone mass and biomechanical strength and is life-threatening to the elderly. In this study, we show that methyl 3,4-dihydroxybenzoate (MDHB), an antioxidant small-molecule compound extracted from natural plants, inhibits ...
Huang Zhaobo, Jiang Zenghui, Zheng Zeyu, Zhang Xuyang, Wei Xiaoan, Chen Jian, Zhao Fengdong   +6 more
doaj   +1 more source

Dietary Polyphenols and Periodontitis—A Mini-Review of Literature [PDF]

, 2018
Periodontitis, which is a chronic infection and disease of the periodontium, is a significant global health burden and is linked to other chronic health conditions such as diabetes and cardiovascular diseases.
Basu, Arpita, Ebersole, Jeffrey L., Masek, Emily   +2 more
core   +2 more sources

Age-related accumulation of advanced oxidation protein products promotes osteoclastogenesis through disruption of redox homeostasis

Cell Death and Disease, 2021
Enhanced osteoclastogenesis is one of the major causes of age-related bone loss. Aging is accompanied by accumulation of advanced oxidation protein products (AOPPs).
Jingshen Zhuang, Xuebing Chen, Guixing Cai, Dizheng Wu, Chen Tu, Siyuan Zhu, Yusheng Huang, Ping Xu, Zhaoming Zhong   +8 more
doaj   +1 more source

Modified Curcuminoid-Rich Extract Liposomal CRE-SDInhibits Osteoclastogenesis via the Canonical NF-κB Signaling Pathway

Pharmaceutics, 2023
Curcuminoids, namely curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are the major active compounds found in Curcuma longa L. (turmeric).
Sompot Jantarawong, Piyawut Swangphon, Natda Lauterbach, Pharkphoom Panichayupakaranant, Yutthana Pengjam   +4 more
doaj   +1 more source

Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway

Cells, 2021
Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells.
So-Yeon Kim, Younseo Oh, Sungsin Jo, Jong-Dae Ji, Tae-Hwan Kim   +4 more
doaj   +1 more source

Asiatic Acid Attenuates Osteoporotic Bone Loss in Ovariectomized Mice Through Inhibiting NF-kappaB/MAPK/ Protein Kinase B Signaling Pathway

Frontiers in Pharmacology, 2022
Osteoporosis is a condition associated with osteolytic bone disease that is primarily characterized by inordinate osteoclast activation. Protein kinase B (Akt) pathways activated by receptor activator of nuclear factor kappa-B ligand (RANKL) are ...
Mingming Dong, Jican Zeng, Chenyu Yang, Yisen Qiu, Xinjia Wang, Xinjia Wang   +5 more
doaj   +1 more source

Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition [PDF]

, 2019
Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain better ...
Ahern, Philip P., Ahmed, Tahmeed, Barile, Daniela, Barratt, Michael J., Cheng, Jiye, Cowardin, Carrie A., Gordon, Jeffrey I., Guruge, Janaki L., Head, Richard D., Hibberd, Matthew C., Huq, Sayeeda, Kung, Vanderlene L., Mills, David A., Sundaresan, Vinaik   +13 more
core   +2 more sources

Extracellular NAD+ metabolism modulates osteoclastogenesis [PDF]

Biochemical and Biophysical Research Communications, 2006
Changes in NAD+ and its metabolites contribute to longevity and age-associated diseases. The role of NAD+ metabolism in bone diseases has however not been investigated, despite the fact that osteoporosis is a leading cause of morbidity in old age. TRAP(+) osteoclast formation from C57 Bl/6J mice was assessed after the addition of varying concentrations
Jameel, Iqbal, Mone, Zaidi
openaire   +2 more sources

All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity

Cell & Bioscience, 2018
Background Bone regenerative heterodimeric bone morphogenetic protein 2/7 (BMP2/7) enhances but all-trans retinoic acid (ATRA) inhibits osteoclastogenesis.
Wenjuan Bi, Yi Liu, Jing Guo, Zhen Lin, Jinsong Liu, Miao Zhou, Daniel Wismeijer, Janak L. Pathak, Gang Wu   +8 more
doaj   +1 more source

Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation

Bone Reports, 2019
Osteoporosis is a disease that impacts over 200 million people worldwide. Taking into consideration the side effects stemming from medications used to treat this illness, investigators have increased their efforts to develop novel therapeutics for ...
Darin Quach, Narayanan Parameswaran, Laura McCabe, Robert A. Britton   +3 more
doaj   +1 more source