Results 31 to 40 of about 31,404 (249)

Inhibition of Human Osteoclast Differentiation by Kynurenine through the Aryl-Hydrocarbon Receptor Pathway

Cells, 2021
Aryl-hydrocarbon receptor (AhR) is a ligand-activated transcription factor and regulates differentiation and function of various immune cells such as dendritic cells, Th17, and regulatory T cells.
So-Yeon Kim, Younseo Oh, Sungsin Jo, Jong-Dae Ji, Tae-Hwan Kim   +4 more
doaj   +1 more source

Characterizing how probiotic Lactobacillus reuteri 6475 and lactobacillic acid mediate suppression of osteoclast differentiation

Bone Reports, 2019
Osteoporosis is a disease that impacts over 200 million people worldwide. Taking into consideration the side effects stemming from medications used to treat this illness, investigators have increased their efforts to develop novel therapeutics for ...
Darin Quach, Narayanan Parameswaran, Laura McCabe, Robert A. Britton   +3 more
doaj   +1 more source

Asiatic Acid Attenuates Osteoporotic Bone Loss in Ovariectomized Mice Through Inhibiting NF-kappaB/MAPK/ Protein Kinase B Signaling Pathway

Frontiers in Pharmacology, 2022
Osteoporosis is a condition associated with osteolytic bone disease that is primarily characterized by inordinate osteoclast activation. Protein kinase B (Akt) pathways activated by receptor activator of nuclear factor kappa-B ligand (RANKL) are ...
Mingming Dong, Jican Zeng, Chenyu Yang, Yisen Qiu, Xinjia Wang, Xinjia Wang   +5 more
doaj   +1 more source

Tetrandrine Prevents Bone Loss in Ovariectomized Mice by Inhibiting RANKL-Induced Osteoclastogenesis

Frontiers in Pharmacology, 2020
Postmenopausal osteoporosis (PMOP) is a metabolic bone disease characterized by decreased bone density and strength due to the imbalance between osteogenesis and osteoclastogenesis.
Zeyuan Zhong, Zhi Qian, Xu Zhang, Fancheng Chen, Shuo Ni, Zhanrong Kang, Fangxue Zhang, Dejian Li, Baoqing Yu   +8 more
doaj   +1 more source

Nrf2 activation in osteoblasts suppresses osteoclastogenesis via inhibiting IL-6 expression.

Bone Reports, 2019
Bone destructive diseases such as periodontitis and rheumatoid arthritis are caused by excessive activation of osteoclasts. Osteoclastogenesis is regulated by Receptor activator of nuclear factor kappa-β ligand (RANKL) produced by osteoclastogenesis ...
Tsuyoshi Narimiya, Hiroyuki Kanzaki, Yuki Yamaguchi, Satoshi Wada, Yuta Katsumata, Ken Tanaka, Hiroshi Tomonari   +6 more
doaj   +1 more source

A microRNA expression signature of osteoclastogenesis

Blood, 2011
AbstractMicroRNAs (miRs) are small noncoding RNAs that principally function in the spatiotemporal regulation of protein translation in animal cells. Although emerging evidence suggests that some miRs play important roles in osteoblastogenesis and skeletal homeostasis, much less is known in osteoclastogenesis.
Toshifumi, Sugatani, Jean, Vacher, Keith A, Hruska   +2 more
openaire   +3 more sources

Effects of the Germinated Glycine max and Angelica gigas Nakai Mixture on Hepatic Lipid Metabolism and Bone Turnover Balance in Ovariectomized Rats

Applied Sciences, 2023
Women going through menopause experience changes in their hormone levels, such as decreased estrogen secretion. Those changes can lead to weight gain and steatosis (fatty liver) due to abnormal lipid metabolism and bone turnover. Natural herbal medicines
Sangmin Lee, Yunsang Cho, Jihye Choi, Hwal Choi, Tae Sung Jung, Jungkee Kwon   +5 more
doaj   +1 more source

Low-Level Laser Irradiation Stimulates RANKL-Induced Osteoclastogenesis via the MAPK Pathway in RAW 264.7 Cells

Applied Sciences, 2021
Low-level laser therapy (LLLT) is recognized as an effective medical tool for the treatment of various conditions requiring tissue repair, pain relief, inflammation treatment, and restoration of tissue dysfunction, and its development and research are ...
Jae-Min Song, Bong-Soo Park, Sang-Hun Shin, In-Ryoung Kim   +3 more
doaj   +1 more source

The Role of Calmodulin in the Regulation of Osteoclastogenesis [PDF]

Endocrinology, 2003
Calmodulin plays an important role in regulating the function of mature osteoclasts. However, its role in osteoclastogenesis has not been investigated. In the present study, we examined the role of calmodulin in osteoclastogenesis using in vivo and in vitro systems.
Liang, Zhang, Xu, Feng, Jay M, McDonald
openaire   +2 more sources

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source