Results 31 to 40 of about 36,147 (282)

CK2.3 inhibits osteoclastogenesis in a proliferation-independent manner

, 2021
The role of BMPs in bone homeostasis and repair led to the approval of BMP2 by the Federal Drug Administration (FDA) for anterior lumbar interbody fusion (ALIF) to increase the bone formation in the treated area.
Heubel, Brian
core   +1 more source

Pristimerin Suppresses RANKL-Induced Osteoclastogenesis and Ameliorates Ovariectomy-Induced Bone Loss

Frontiers in Pharmacology, 2021
Osteoporosis is characterized by bone loss and destruction of trabecular architecture, which greatly increases the burden on the healthcare system.
Dahu Qi, Hui Liu, Hui Liu, Xuying Sun, Danni Luo, Meipeng Zhu, Tenghui Tao, Chenghao Gao, Chuankun Zhou, Wei Zhou, Jun Xiao   +10 more
doaj   +1 more source

Bortezomib inhibits human osteoclastogenesis [PDF]

Leukemia, 2007
In multiple myeloma, the overexpression of receptor activator of nuclear factor kappa B (NF-kappaB) ligand (RANKL) leads to the induction of NF-kappaB and activator protein-1 (AP-1)-related osteoclast activation and enhanced bone resorption. The purpose of this study was to examine the molecular and functional effects of proteasome inhibition in RANKL ...
I, von Metzler, H, Krebbel, M, Hecht, R A, Manz, C, Fleissner, M, Mieth, M, Kaiser, C, Jakob, J, Sterz, L, Kleeberg, U, Heider, O, Sezer   +11 more
openaire   +2 more sources

Osteoclastogenesis and Osteogenesis

International Journal of Molecular Sciences, 2022
Bone is a highly dynamic tissue that is continuously remodeled to attain and maintain optimal bone integrity, mass, and strength [...]
openaire   +2 more sources

Modulation of Osteoclastogenesis by Fatty Acids [PDF]

Endocrinology, 2008
Clinical studies have shown that total body fat mass is related to both bone density and fracture risk and that fat ingestion reduces bone turnover. These effects are at least partially mediated by endocrine mechanisms, but it is possible that lipids might act directly on bone.
Cornish, J, MacGibbon, A, Lin, J, Watson, M, Callon, K, Tong, P, Dunford, J, van der Does, Y, Williams, G, Grey, AB, Naot, D, Reid, I   +11 more
openaire   +2 more sources

Osteoclastogenesis and osteoimmunology

Frontiers in Bioscience, 2014
Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass and architecture by osteoclasts (bone resorption) and osteoblasts (bone formation). Bone resorption is an elementary cellular activity in the modeling of the skeleton during growth and development ...
Wei, Feng, Wei, Xia, Qing, Ye, Weibing, Wu   +3 more
openaire   +2 more sources

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

, 2016
Background: Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.
Karonitsch, Thomas, Hayer, Silvia, Scholze, Petra, Mócsai, Attila, Győri, Dávid Sándor, Mandl, Péter, Poór, Gyula   +6 more
core   +2 more sources

Vitamin B-12 deficiency stimulates osteoclastogenesis via increased homocysteine and methylmalonic acid [PDF]

, 2009
The risk of nutrient deficiencies increases with age in our modern Western society, and vitamin B(12) deficiency is especially prevalent in the elderly and causes increased homocysteine (Hcy) and methylmalonic acid (MMA) levels.
Bravenboer, N., Vaes, Bart L T, Vaes, B.L.T., Everts, V., Wilma T. Steegenga, Bravenboer, Nathalie, Steegenga, W.T., Lute, Carolien, Carolien Lute, de Groot, L.C.P.G.M., Müller, M.R., Henk J. Blom, de Groot, C.P.G.M., Muller, M., Dhonukshe-Rutten, R.A.M., de Groot, Lisette C P G M, Dhonukshe-Rutten, R.A., Bart L. T. Vaes, Teun J. de Vries, Blom, Henk J, Nathalie Bravenboer, Groot, L.C.P.G.M. de, de Vries, Teun J, Müller, Michael, Everts, Vincent, Rosalie A. Dhonukshe-Rutten, Michael Müller, de Vries, T.J., Lisette C. P. G. M. de Groot, Dhonukshe-Rutten, Rosalie A, Steegenga, Wilma T, Groot, C.P.G.M., de, Lute, C., Vries, T. J., Blom, H.J., Everts, V, Vries, T.J., de, Vincent Everts   +37 more
core   +1 more source

TGF-βRI kinase activity mediates Emdogain-stimulated in vitro osteoclastogenesis. [PDF]

, 2014
OBJECTIVES Emdogain, containing an extract of fetal porcine enamel matrix proteins, is a potent stimulator of in vitro osteoclastogenesis. The underlying molecular mechanisms are, however, unclear.
Gruber, Reinhard, Reinhard Gruber, Rick Miron, Jordi Caballé-Serrano, Roos, Gilles, Gilles Roos, Miron, Rick, Anton Sculean, Sculean, Anton, Bosshardt, Dieter, Dieter D. Bosshardt, Caballé Serrano, Jordi   +11 more
core   +1 more source

Collagen-like Osteoclast-Associated Receptor (OSCAR)-Binding Motifs Show a Co-Stimulatory Effect on Osteoclastogenesis in a Peptide Hydrogel System

, 2023
Osteoclastogenesis, one of the dynamic pathways underlying bone remodelling, is a complex process that includes many stages. This complexity, while offering a wealth of therapeutic opportunities, represents a substantial challenge in unravelling the ...
Richardson, Stephen M; id_orcid, Hoyland, Judith A., Richardson, Stephen M., Cosimo Ligorio, Ligorio, Cosimo, Vitale, Mattia, Bella, Jordi, Mattia Vitale, Judith A. Hoyland, Hoyland, Judith A, Stephen M. Richardson, Jordi Bella   +11 more
core   +1 more source