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NFATc1 in Inflammatory and Musculoskeletal Conditions
2009The nuclear factor of activated T-cells (NFAT) family of transcription factors specify developmental pathways and cell fate in vertebrates. NFATc1, in particular, is crucial to multiple seemingly unrelated biologic processes, including heart valve formation, T-cell activation, osteoclast development, and the mitigation of hair follicle stem cell ...
Antonios O, Aliprantis +1 more
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NFATc1: A Novel Anabolic Therapeutic Target for Osteoporosis
Annals of the New York Academy of Sciences, 2006Abstract: Bone loss and osteoporosis are major public health problems in the elderly. With increasing life expectancy in the United States, the number of people that will develop age‐related bone loss and osteoporosis is expected to rise to over 61 million by 2020.
Hyeonju, Yeo +2 more
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NFATc1 autoregulation: a crucial step for cell-fate determination
Trends in Immunology, 2006Nuclear factor of activated T cell c (NFATc) transcription factors appeared in evolution with the emergence of lymphocytes in jawed fish. They have decisive roles in the development of the immune system and adaptive immune responses. Following immunoreceptor stimulation, NFAT factors control the expression of a large set of genes and thereby the fate ...
Edgar, Serfling +4 more
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Noncanonical NFATc1 activation in DN thymocytes
Nature Immunology, 2013Double-negative (DN) thymocytes depend on interleukin 7 (IL-7) for survival. In DN2 and DN3 cells, a new role has now been identified for signaling via the IL-7 receptor and the kinase Jak3 that leads to noncanonical activation of the transcription factor NFATc1 and upregulation of expression of the antiapoptotic protein Bcl-2.
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Retinoic acid inhibits NFATc1 expression and osteoclast differentiation
Journal of Bone and Mineral Metabolism, 2011Ingestion of excess vitamin A appears to correlate with an increased fracture risk, an outcome that is likely mediated by retinoic acids (RAs); these are vitamin A metabolites that have dramatic effects on skeletal development. We studied the impacts of RA and isoform-specific RA receptor (RAR) agonists (α, β, and γ) on osteoclast formation ...
Wayne, Balkan +4 more
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NFATC1 modulation of atrial excitability in zebrafish
Biophysical Journal, 2023Natalia S. Torres +3 more
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Identification and characterization of NFATc1+ skeletal stem cells in bone regeneration
Cell Reports, 2022Fanyuan Yu, Feifei Li, Ling Ye
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