Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1 [PDF]
Frontiers in Immunology, 2019 Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody ...
Claudia Schröder +20 more
doaj +5 more sources
Alternatively spliced NFKB1 transcripts enriched in Andean Aymara modulate inflammation, HIF and hemoglobin [PDF]
Nature CommunicationsThe molecular basis of increased hemoglobin in Andean Aymara highlanders is unknown. We conducted an integrative analysis of whole-genome-sequencing and granulocytes transcriptomics from Aymara and Europeans in Bolivia to explore genetic basis of the ...
Jihyun Song +9 more
doaj +3 more sources
Transcription factor NFKB1 mediates TUBB6 to promote the proliferation and suppress apoptosis in glioma via Wnt/β-catenin signaling pathway [PDF]
Discover OncologyGlioma remains one of the most challenging brain tumors with poor prognosis. In this study, we aimed to elucidate the role of TUBB6 in glioma and its potential as a diagnostic and prognostic biomarker.
Yan Li +4 more
doaj +3 more sources
MYD88, NFKB1, and IL6 transcripts overexpression are associated with poor outcomes and short survival in neonatal sepsis [PDF]
Scientific Reports, 2021 Toll-like receptor (TLR) family signature has been implicated in sepsis etiopathology. We aimed to evaluate the genetic profile of TLR pathway-related key genes; the myeloid differentiation protein 88 (MYD88), IL1 receptor-associated kinase 1 (IRAK1 ...
Nouran B. AbdAllah +6 more
doaj +2 more sources
A functional haplotype of NFKB1 influence susceptibility to oral cancer: a population‐based and in vitro study [PDF]
Cancer Medicine, 2018 Genetic variations of NF‐κB and its inhibitor IκB genes and their biological mechanism in oral cancer were not well recognized. The purpose of this study was to evaluate the associations of polymorphisms in NFKB1 and NFKBIA with oral cancer ...
Fa Chen +10 more
doaj +2 more sources
Cross-tissue transcriptome-wide association study reveals novel psoriasis susceptibility genes [PDF]
Journal of Translational AutoimmunityBackground: Psoriasis is a chronic, immune-mediated inflammatory skin disorder with a strong genetic component. Although numerous GWAS have identified risk loci, many associated variants lie in non-coding regions, complicating functional interpretation ...
Fei Yan +4 more
doaj +2 more sources
Functional promoter -94 ins/del ATTG polymorphism in NFKB1 gene is associated with bladder cancer risk in a Chinese population. [PDF]
PLoS ONE, 2013 BACKGROUND: A functional -94 insertion/deletion polymorphism (rs28362491) in the promoter of the NFKB1 gene was reported to influence NFKB1 expression and confer susceptibility to different types of cancer.
Pengchao Li +9 more
doaj +3 more sources
Identification and construction of prognostic clusters and risk-prognosis model based on aging-immune related genes in bladder cancer [PDF]
Discover OncologyBackground Faced with the current global ageing situation, advanced age has become a risk factor for bladder carcinogenesis progression and immunotherapy.
Nihao Cao +3 more
doaj +2 more sources
NFKB1-targeted metabolites as novel therapeutic approaches for erectile dysfunction: evidence from gut microbiota network pharmacology and machine learning. [PDF]
Sex MedXiang B, An J, Li D.
europepmc +2 more sources
A novel NFKB1 agonist remodels tumor microenvironment and activates dendritic cells to promote anti-tumor immunity in colorectal cancer. [PDF]
J Transl MedChen Y, Li Q, Wang Z, Sun LV, Hou SX.
europepmc +2 more sources