Results 161 to 170 of about 37,410 (228)
Population Pharmacokinetics and Pharmacodynamics of Depemokimab in People with Asthma and Chronic Rhinosinusitis with Nasal Polyps
The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.Abstract
Depemokimab is the first ultra‐long‐acting biologic with enhanced interleukin‐5 (IL‐5) binding affinity, high potency, and extended half‐life, enabling twice‐yearly dosing. Depemokimab has demonstrated efficacy and safety in patients with asthma and chronic rhinosinusitis with nasal polyps.Anders Thorsted, Lénaïg Tanneau, Alexandra Lavalley‐Morelle, Richard Follows, Loretta Jacques, Nicholas Bird, Philippe Gevaert, Ian Pavord, Jakob Ribbing, Anubha Gupta, Peter Howarth, Stein Schalkwijk +11 morewiley +1 more sourceCorticosterone Under Experimental Manipulation of Nutrition and Parasite Burden in a Wild Rodent System
Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 345, Issue 7, Page 749-758, August 2026.ABSTRACT
Environmental pressures shape survival and life‐history dynamics partly by triggering the release of glucocorticoids, whose short‐term benefits but long‐term costs make it essential to understand what drives their levels. Here, we used an experimental manipulation of two environmental stressors—food availability and parasite burden—to directly Sarah E. Wolf, Olga Dłużniewska, Simon A. Babayan, Amy B. Pedersen, Tom J. Little +4 morewiley +1 more sourceHarnessing Tumor‐Specific Transcript Diversity Uncovers a Shared Neoantigen Reservoir for Pancreatic Ductal Adenocarcinoma
MedComm, Volume 7, Issue 8, August 2026.This study introduces NeoAPP, a computational tool revealing that transcriptional dysregulation generates a dominant reservoir of neoantigens from tumor‐specific transcripts (TSTs) in pancreatic ductal adenocarcinoma (PDAC), far exceeding those of mutational origin.Jingjing Zhao, Qiaojuan Li, Peng Lin, Yu Yang, Hongwu Yu, Yifan Wen, Wenqian Yu, Huiyi He, Sichen Tao, Feifei Zhang, Yan Li, Zhixiang Hu, Jing Xie, Zhen Chen, Shenglin Huang +14 morewiley +1 more sourceSequence of Immunological Events During IgE‐Mediated Allergic Reactions to Food
Allergy, Volume 81, Issue 8, Page 2726-2743, August 2026.ABSTRACT
Food allergies (FA) represent a significant global health burden. Upon allergen re‐exposure, allergic patients exhibit a sequence of symptoms that vary in terms of affected organ systems, severity, time of onset and allergen reactivity thresholds.N. A. Nagy, D. Schnoegl, V. Houghton, L. O'Mahony, A. F. Santos, E. F. Knol, A. Kuehn, T. Eiwegger +7 morewiley +1 more sourceThe International Guideline for the Definition, Classification, Diagnosis and Management of Urticaria
Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.ABSTRACT
This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...Torsten Zuberbier, Zainab AbdulHameed Ansari, Amir H. Abdul Latiff, M. M. Abuzakouk, Maria Socorro Agcaoili‐De Jesus, Rosana C. Agondi, Mona Al‐Ahmad, Abdullah A. Alangari, H. Alhameli, Cesar D. Alonso Bello, Saad Alshareef, Salem Al‐Tamemi, Sabine Altrichter, Humaid Al Wahshi, S. Aquilina, M. Araújo, Rand Arnaout, Riccardo Asero, Barbara Ballmer‐Weber, Christine Bangert, Andrea Bauer, Moshe Ben‐Shoshan, Jonathan A. Bernstein, Carsten Bindslev‐Jensen, Mojca Bizjak, Isabelle Boccon‐Gibod, Hanna Bonnekoh, Laurence Bouillet, Knut Brockow, Zenon Brzoza, M. Bulatović Ćalasan, Adeeb Bulkhi, Thomas Buttgereit, Anette Bygum, Teresa Caballero, Oscar Calderon, R. Campos, Mauro Cancian, Emily Carne, Mary Anne Castor, Inmaculada Cerecedo, T. Çetinarslan, Ivan Cherrez‐Ojeda, N. Chkhikvadze, Herberto J. Chong‐Neto, Karen Choo, George Christoff, Chia‐Yu Chu, K. Ciupka, Niall Conlon, Célia Costa, Timothy J Craig, Paulo Criado, Inna Danilycheva, Razvigor Darlenski, Erika De Arruda Chaves, Laurence de Montjoye, M.‐S. Doutre, Aurelie Du‐Thanh, Didier Ebo, S. Elkhalifa, S. Elmariah, Tariq El‐Shanawany, Luis F. Ensina, Ragip Ertaş, Roberta Fachini Jardim Criado, Marta Ferrer, Silvia Ferrucci, Jie Shen Fok, Daria Fomina, Luz Fonacier, Ghada Fouda, I. Francescantonio, Atsushi Fukunaga, César A. Galvan Calle, Elizabeth Garcia, Krisztian Gáspár, Aslı Gelincik, Songmei Geng, Kiran Godse, Margarida Gonçalo, Maia Gotua, C. Grattan, Martine Grosber, Guillermo Guidos Fogelbach, Mar Guilarte, R. Guillod, Eckard Hamelmann, Jason Hawkes, Koremasa Hayama, Ruben Heuer, Michihiro Hide, Wolfram Hoetzenecker, Naoko Inomata, Hye‐Ryun Kang, Allen P. Kaplan, Alexander Kapp, M. Karam, Alicja Kasperska‐Zajac, Constance H. Katelaris, Aharon Kessel, Maryam Khoshkhui, Brian Kim, Tamar Kinaciyan, Emek Kocatürk, Marta Kolacinska‐Flont, Pavel Kolkhir, George N. Konstantinou, Mitja Kosnik, Dorota Krasowska, Kanokvalai Kulthanan, Muthu S. Kumaran, Izabela Kuprys‐Lipinska, Moisés Labrador, Jose Ignacio Larco, Désirée Larenas‐Linnemann, Elena Latysheva, E. Lazaridou, Philip H. Li, H. Lima, Undine Lippert, Markus Magerl, Michael Makris, João Alves Marcelino, Angelo V. Marzano, Iris Medina, Raisa Meshkova, D. Micallef, Ramzy Mohammed Ali, Charlotte G. Mortz, Melba Munoz, Hanneke N. G. Oude Elberink, Alla Nakonechna, Iman Nasr, Alexander Nast, Elena Netchiporouk, Eustachio Nettis, Sandra Nieto, Isabel Ogueta Canales, T.‐L. Okas, Raquel L. Orfali, Esen Özkaya, Claudio Parisi, A. Pennitz, Ruby Pawankar, Manuel P. Pereira, Jonny Peter, Elena Petkova, P. D. Pigatto, Indrashis Podder, T. Popov, Grzegorz Porebski, Polina Pyatilova, German D. Ramon, Hector A. Ratti Sisa, Marysia Stella Recto, Krista Ress, Katie Ridge, Marc Riedl, Carla Ritchie, Nelson Rosario Filho, Isabel Rosmaninho, Michael Rudenko, Maia Rukhadze, Krzysztof Rutkowski, Vito Sabato, Umit M. Sahiner, Sarbjit Saini, F. Saleh Al Sabbagh, Andac Salman, Fulvio Salvo, Jorge Sanchez, A. Santucci, Sibylle Schliemann, Peter Schmid‐Grendelmeier, Bulent E. Sekerel, Faradiba Serpa, Farrukh Sheikh, J. Sheikh, H. Shendi, Frank Siebenhaar, M. Sonomjamts, Angele Soria, Bernardo Sousa Pinto, Maria Staevska, Petra Staubach, M. Stephan, Katarina Stevanovic, Luca Stingeni, Marcin Stobiecki, Özlem Su Küçük, Gordon Sussman, Andrea Szegedi, Shunsuke Takahagi, Akio Tanaka, Natasa Teovska Mitrevska, Simon Francis Thomsen, Elias Toubi, Fragkiski Tsatsou, Murat Turk, Zahava Vadasz, Anna Valerieva, Solange Valle, Martijn van Doorn, Beatriz Veleiro Perez, Carolina E. Vera Ayala, Christian Vestergaard, Rafael J. Vieira, C. W. Maruta, Bettina Wedi, Ricardo N. Werner, Evelyn Wen Yee Yap, Paraskevi Xepapadaki, Yi‐Kui Xiang, Young‐Min Ye, Patrick Yong, Gil Yosipovitch, Anna Zalewska‐Janowska, Christoph Zeyen, Zuotao Zhao, Martin Metz, Ana M. Giménez‐Arnau +221 morewiley +1 more sourceSuccessful Application of the Mast Cell Activation Test in Immediate Hypersensitivity to Amoxicillin
Allergy, Volume 81, Issue 8, Page 2910-2922, August 2026.This study included 28 amoxicillin‐allergic patients and 11 healthy exposed controls. Mast cells were differentiated from CD34+ progenitors over 8 weeks using cytokine cocktails. The mast cell activation test involved sensitization with patient or control sera and stimulation with free amoxicillin or G4/G5‐AXO dendrimers with successfully activated ...Jose A. Céspedes, Clara Lebrón‐Martín, Lucía Vallecillos‐Azor, Pablo Torres, Amene Tesfaye Ayane, Gádor Bogas, María Salas, Adriana Ariza, María Isabel Montañez, María José Torres, Carlos José Aranda, Cristobalina Mayorga +11 morewiley +1 more source
