The FASEB Journal, Volume 40, Issue 3, 15 February 2026.The nociceptive properties of differentiated human HD10.6 cells were characterized by multiple approaches (A). Peripheral sensitization was induced within HD10.6 cells in response to an inflammatory cocktail (B), modeling nociceptors in a chronic pain state.
Sara A. Dochnal +11 more
wiley +1 more source
MSC-EVs alleviate osteoarthritic joint pain and degeneration by suppressing IL-1β/NGF signaling. [PDF]
Genes DisTeo KYW, Wen C, Wong RCW, Toh WS.
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Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, Volume 16, Issue 2, Page 252-267, February 2026.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Assessment of Post-Discharge Growth Pattern After Initial Growth Faltering and Its Association with the Neurodevelopment Status in Preterm Infants: A Cohort Study. [PDF]
NutrientsCastro AW +3 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.A multifunctional, 3D porous neural interface combines non‐viral gene delivery and NIR optogenetics to enable minimally invasive, closed‐loop modulation of deep‐brain circuits. Abstract Closed‐loop neuromodulation requires precise, stable, and cell‐specific control of neural circuits with minimal invasiveness.
Chao‐Yi Chu +14 more
wiley +1 more source
Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative Changes
Advanced Science, Volume 13, Issue 7, 3 February 2026.In TMJ‐OA, osteoclasts play a significant role in promoting the growth of sensory nerves at the osteochondral interface. In early OA, TRAP+ osteoclast‐derived SLIT3 induces sensory nerve growth into the condylar cartilage. This nerve growth facilitates the development of pain associated with OA.
Weiwei Zhu +13 more
wiley +1 more source
Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation [PDF]
, 2002 Subhas C. Biswas, Lloyd A. Greene
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Biological Templates for Gold Nanocluster Assembly: Design and Biomedical Applications
Aggregate, Volume 7, Issue 2, February 2026.The review discusses the fundamental properties of ultrasmall gold nanoclusters and their surface modification strategies for targeted biomedical use. It examines biologically guided assembly processes and their effects on optical behavior, particularly aggregation‐induced emission.
Zeineb Ayed +3 more
wiley +1 more source
NGF/BDNF-Trk/p75NTR signaling in osteosarcoma immunity: biomarkers and therapeutic opportunities. [PDF]
Front ImmunolAn L, Zhuang Y, Sun H.
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