Results 81 to 90 of about 87,888 (339)
Clinical Pharmacology &Therapeutics, EarlyView.Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano +8 more
wiley +1 more source
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Nutrients, 2020 Dysbiosis is implicated by many studies in the pathogenesis of Parkinson’s disease (PD). Advances in sequencing technology and computing have resulted in confounding data regarding pathogenic bacterial profiles in conditions such as PD.
T. Karunaratne +5 more
semanticscholar +1 more source
Food Biomacromolecules, EarlyView.Abstract Metabolic syndrome (MetS) is a complex noncommunicable condition characterized by central obesity, insulin resistance, hyperlipidemia, hypertension, and hyperglycemia. Epidemiological evidence shows that MetS affects a third of the global population; however, due to its complex pathogenesis and limited drug therapy options, the increasing ...
Josiah Owuor Oyalo +3 more
wiley +1 more source
Niacin increases adiponectin and decreases adipose tissue inflammation in high fat diet-fed mice.
PLoS ONE, 2013 AimsTo determine the effects of niacin on adiponectin and markers of adipose tissue inflammation in a mouse model of obesity.Materials and methodsMale C57BL/6 mice were placed on a control or high-fat diet (HFD) and were maintained on such diets for the ...
Desiree Wanders +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2023 Large plots of maize in agricultural landscapes are associated with reduced reproductive output of females and impaired population development of free-living populations of European brown hares (Lepus europaeus, Pallas 1778).
Aldin Selimovic +6 more
doaj +1 more source
Food Biomacromolecules, EarlyView.Abstract The generation of by‐products from fruit and vegetable (F&V) processing industries poses opportunities and challenges, containing essential nutrient sources necessary for human health. The present study comprehensively analyzes the nutrient compositions and fatty acid content of by‐products derived from apples, pomegranate, beetroot, carrots ...
Anwesha Mahajan +5 more
wiley +1 more source
Niacin as a drug repositioning candidate for hyperphosphatemia management in dialysis patients
Therapeutics and Clinical Risk Management, 2014 Sooyoung Shin, Sukhyang LeeAjou University College of Pharmacy, Yeongtong-gu, Suwon-si, Gyeonggi-do, Korea Abstract: Nearly all patients with end-stage renal disease develop hyperphosphatemia.
Shin S, Lee S
doaj
Upregulation of GPR109A in Parkinson's disease. [PDF]
PLoS ONE, 2014 Anecdotal animal and human studies have implicated the symptomatic and neuroprotective roles of niacin in Parkinson's disease (PD). Niacin has a high affinity for GPR109A, an anti-inflammatory receptor.
Chandramohan Wakade +4 more
doaj +1 more source