Results 91 to 100 of about 3,289 (188)

Coordinated and widespread expression of γ-secretase in vivo: evidence for size and molecular heterogeneity

Neurobiology of Disease, 2004
γ-Secretase is a high molecular weight protein complex composed of four subunits, namely, presenilin (PS; 1 or 2), nicastrin, anterior pharynx defective-1 (Aph-1; A or B), and presenilin enhancer-2 (Pen-2), and is responsible for the cleavage of a number
Sébastien S. Hébert, Lutgarde Serneels, Tim Dejaegere, Katrien Horré, Michal Dabrowski, Veerle Baert, Wim Annaert, Dieter Hartmann, Bart De Strooper   +8 more
doaj   +1 more source

Screening nicastrin antibodies for specificity for immunofluorescence (934.2)

The FASEB Journal, 2014
Alzheimer’s disease is a type of dementia that can cause problems with memory, learning and behavior. Nicastrin is a component of the protein complex involved in the development of Alzheimer’s disease. In our lab, tissue‐specific nicastrin conditional knockout mice were developed and displayed a striking neurological phenotype. The aim of this research
Derek Deshaies, Gang Yu, Daniel Dries
openaire   +1 more source

Nicastrin Is Dispensable for γ-Secretase Protease Activity in the Presence of Specific Presenilin Mutations [PDF]

, 2009
Eugene Futai, Sosuke Yagishita, Shoichi Ishiura   +2 more
openalex   +1 more source

Effects of lipids on the activity and structural dynamics of gamma secretase: A study using coarse-grained molecular dynamics simulations

ChemPhysMater
Gamma secretase (GS) is an intramembranous enzyme that acts on the amyloid precursor protein and Notch inside lipid membranes. The enzyme is responsible for amyloid-β propagation, one of the well-known causes of Alzheimer's disease.
Ahmad Sajjad, Jinfei Mei, Chuanbo Wang, Hongqi Ai   +3 more
doaj   +1 more source

Nicastrin Mutations in French Families with Hidradenitis Suppurativa [PDF]

Journal of Investigative Dermatology, 2012
Miskinyte, Snaigune, Nassif, Aude, Merabtene, Fatiha, Ungeheuer, Marie-Noëlle, Join-Lambert, Olivier, Jais, Jean-Philippe, Hovnanian, Alain   +6 more
openaire   +2 more sources

Positive and Negative Regulation of the γ-Secretase Activity by Nicastrin in a Murine Model [PDF]

, 2003
Jinhe Li, Gregory J. Fici, Chai‐An Mao, Richard L. Myers, Rongqing Shuang, Gregory P. Donoho, Adele M. Pauley, Carol S. Himes, Wenning Qin, Ismail Kola, Kalpana Merchant, Jeffrey S. Nye   +11 more
openalex   +1 more source

Erratum to: Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells [PDF]

, 2014
Aleksandra Filipović, Ylenia Lombardo, Monica Faronato, Joel Abrahams, Eric O. Aboagye, Quang‐Dé Nguyen, Barbara Borda d’Aqua, Anne J. Ridley, Andrew R. Green, Emad Rahka, Ian O. Ellis, Chiara Recchi, Nataša Pržulj, Anida Sarajlić, Jean‐René Alattia, Patrick C. Fraering, Mahendra P. Deonarain, R. Charles Coombes   +17 more
openalex   +1 more source

Identification of binding sites in nicastrin and binding modes of its inhibitors

, 2023
Ngceboyakwethu P. Zinyama, Upenyu Guyo, Grace Mugumbate   +2 more
openalex   +1 more source

0599 Plastic associated endocrine disruptors reduce nicastrin protein and potentiate inflammation in hidradenitis suppurativa [PDF]

K.L. Williams, Beita Badiei, John P. Reilly, William Andrews, Hana Minsky, Nina Rossa Haddad, Enid E. Martinez, Mo Sun, Sam-Sun Lee, Li Y, L. Curvin-Aquilla, Alan Johnson, A. Willis, C. Kirby, Amy van Ee, Yingchao Xue, Carrie A Cox, Sanjay Rajagopalan, Sewon Kang, K. Kannan, Julie Caffrey, Nick Archer, Maureen A. Kane, Luis A. Garza   +23 more
openalex   +1 more source

POTENTIAL ALTERATION IN THE NICASTRIN LEVELS IN ALZHEIMER’S DISEASE CEREBROSPINAL FLUID

IBRO Neuroscience Reports, 2023
Luis Felipe Hernández-Villamizar, María Salud García-Ayllón, Rocío Pérez-González, Henrik Zetterberg, Kaj Blennow, Javier Sáez-Valero   +5 more
doaj   +1 more source